Regulation of mitochondria-lysosome interactions in muscle: effects of age, biological sex and exercise

肌肉中线粒体-溶酶体相互作用的调节：年龄、生物性别和运动的影响

• 批准号: 478339
• 负责人: Hood David A
• 金额: $ 77.74万
• 依托单位: York University (Toronto, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=478339&lang=en
• 关键词: Aging; Exercise; Gene Expression; Lysosomes; Mitochondria; Mitochondrial Biogenesis; Mitophagy; Sex Differences; Skeletal Muscle; Tfe3 Transcription Factor; Aging; Exercise; Gene Expression; Lysosomes; Mitochondria; Mitochondrial Biogenesis; Mitophagy; Sex Differences; Skeletal Muscle; Tfe3 Transcription Factor

Mitochondria are the organelles responsible for energy (ATP) production in cells. As we age, there is evidence that mitochondrial function in muscle declines. This can result in poor energy production, fatigue and decreased quality of life. However, the r

线粒体是负责细胞中能量（ATP）产生的细胞器。随着年龄的增长，有证据表明肌肉中的线粒体功能下降。这可能导致能源生产不良，疲劳和生活质量下降。但是，r