Capturing tissue-specific progenitors from embryos and stem cells

从胚胎和干细胞中捕获组织特异性祖细胞

• 批准号: DP190102793
• 负责人: Prof Patrick Tam
• 金额: $ 40.67万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102793
• 关键词: Capturing; tissue; specific; progenitors; embryos

This project aims to delineate the precursor cells in the embryo that give rise specifically to major cell types in the body. The project will use genetic analysis to elucidate the critical genetic activity that underpins the genesis of these precursor cells and to track the trajectory and the scope of cell differentiation. The embryological knowledge will provide insights into the fundamentals of developmental process for generating cellular diversity and enable identifying unique precursors and the evaluation of the efficacy of deriving the biological relevant cell types from the stem cells. This project expects to have a significant impact on the translation to cell production methodology for tissue engineering and bioreactor technology.

该项目旨在描绘胚胎中专门产生体内主要细胞类型的前体细胞。该项目将利用遗传分析来阐明支撑​​这些前体细胞起源的关键遗传活动，并跟踪细胞分化的轨迹和范围。 胚胎学知识将深入了解产生细胞多样性的发育过程的基础知识，并能够识别独特的前体并评估从干细胞衍生生物相关细胞类型的功效。 该项目预计将对组织工程和生物反应器技术的细胞生产方法的转化产生重大影响。