Assembling the building blocks in the blueprint of the embryonic head

在胚胎头部的蓝图中组装积木

• 批准号: DP240101571
• 负责人: Prof Patrick Tam
• 金额: $ 51.63万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101571
• 关键词: Assembling; building; blocks; blueprint; embryonic

This project aims to profile and impute the genome activity and validate the cellular and molecular mechanism underpinning the generation, in time and space, of diverse types of tissues that constitute the building blocks of the embryonic head. The knowledge gain enriches our understanding of the early steps of head formation during embryogenesis in the context of the niche conditions associated with the acquisition of progenitor state, enhancement of lineage propensity, and driving early lineage differentiation. Expected outcome of this research on the developmental biology of a model organism provides a framework of the mechanism of establishing a blueprint of development that may be conserved across multiple mammalian species.

该项目旨在分析和估算基因组活性，并验证构成胚胎头部构建块的不同类型组织在时间和空间上生成的细胞和分子机制。这些知识的获得丰富了我们对胚胎发生过程中头部形成早期步骤的理解，在与祖细胞状态的获得、谱系倾向的增强和驱动早期谱系分化相关的生态位条件的背景下。这项关于模式生物发育生物学的研究的预期结果提供了建立可能在多个哺乳动物物种中保守的发育蓝图的机制框架。