MATERNAL REGULATION OF INFANT PHYSIOLOGY AND BEHAVIOR

婴儿生理和行为的母亲调节

基本信息

批准号：
2674939
负责人：
SEYMOUR LEVINE
金额：
$ 27.05万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-05-01 至 2001-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2674939
关键词：
adrenocorticotropic hormone animal developmental psychology behavioral /social science research tag biological models central nervous system child behavior corticosteroid receptors corticotropin releasing factor developmental neurobiology glucocorticoids laboratory rat mother deprivation neuroendocrine system neurogenesis newborn animals pituitary adrenal axis

项目摘要

Glucocorticoids (GCs) have been shown to affect the development and differentiation of a number of tissues. High perinatal GCs act on the developing central nervous system to permanently alter behavior, homeostatic control mechanisms, and the morphology and physiology of the brain. However, most studies in this area have been pharmacological in nature. In the rat, elevating endogenous GC levels during the perinatal period has been difficult, as there are mechanisms during this period, whereby GC levels are maintained at low and constant levels. Between days 4 and 14, pups do not show a GC response to stressors which, in the adult, normally lead to large GC elevations. This period is known as the "stress hyporesponsive period" (SHRP). However, we have recently observed that following 24 hr of maternal deprivation, rat pups show a marked increase in their GC response to stress (novelty) and ACTH administration at ages at which nondeprived pups show none. Using the maternal deprivation paradigm, we can now elevate endogenous GCs during critical periods of development, and thus, study the neuroendocrine and behavioral consequences of these elevated GCs. Stress during pregnancy in the human has been reported to have deleterious effects on the physiological and psychological development of the child. Many neural systems which develop prenatally in the human do so postnatally in the rat. Thus, the neonatal rat may constitute a good animal model in which to study the effects of GCs on these developmental processes. The proposal has four specific aims: 1) To examine which components of the hypothalamic-pituitary-adrenal system (HPA) are modified by maternal deprivation. GCs, ACTH, CRF, and glucocorticoid receptors will be studied during the 24 hr period of maternal deprivation. 2) To examine which aspect of maternal behavior is responsible for inhibiting the HPA system in the rat pup. 3) To examine whether perinatal maternal deprivation influences the subsequent activity of the HPA system and behavior during the pre- and postweaning period. 4) To examine whether perinatal maternal deprivation alters neuroendocrine activity and behavior in adulthood.

糖皮质激素（GC）已显示出影响发展的和许多组织的分化。高围产期GC 对发展的中枢神经系统行动以永久改变行为，体内控制机制以及形态和大脑的生理学。但是，该领域的大多数研究都有本质上是药理。在大鼠中，抬高内源性围产期期间的GC水平很困难，因为是在此期间保持GC水平的机制在低和恒定水平。在第4至14天之间，幼崽没有显示对压力源的GC反应，在成年人中，通常领导到大型GC高程。这个时期被称为“压力低回应期”（SHRP）。但是，我们最近观察到，孕产妇24小时后剥夺，大鼠幼崽的GC响应显着增加在年龄段的压力（新颖）和ACTH给药非剥夺幼崽没有显示。使用孕产妇剥夺范式，我们现在可以在关键时期提升内源性GC 发展，因此研究神经内分泌和行为这些升高的GC的后果。怀孕期间的压力据报道，人类对孩子的生理和心理发展。许多人类产前发展的神经系统这样做后产后在大鼠中。因此，新生大鼠可能构成在其中研究GC对这些影响的好动物模型发展过程。该提案具有四个具体目标：1）检查哪个下丘脑 - 垂体 - 肾上腺系统（HPA）的组成部分是通过孕产妇剥夺修改。 GCS，ACTH，CRF和糖皮质激素受体将在24小时内进行研究孕产妇的剥夺。 2）检查孕产妇的哪个方面行为负责抑制大鼠的HPA系统小狗。 3）检查围产期孕产妇剥夺是否影响HPA系统和行为的随后活动在断奶前和后期。 4）检查是否围产期孕产妇剥夺会改变神经内分泌活性和成年的行为。

项目成果

期刊论文数量（30）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Maternal regulation of the hypothalamic-pituitary-adrenal axis in the infant rat: the roles of feeding and stroking.

DOI：
10.1016/0165-3806(93)90022-3
发表时间：
1993-10
期刊：
Brain research. Developmental brain research
影响因子：
0
作者：
D. Suchecki;P. Rosenfeld;S. Levine
通讯作者：
D. Suchecki;P. Rosenfeld;S. Levine

Effects of repeated maternal separations on the adrenocortical response to stress of preweanling rats.

反复母体分离对断奶前大鼠肾上腺皮质应激反应的影响。

DOI：
10.1016/0031-9384(92)90415-x
发表时间：
1992
期刊：
Physiology & behavior
影响因子：
2.9
作者：
Rosenfeld,P;Wetmore,JB;Levine,S
通讯作者：
Levine,S

Brain corticotropin-releasing hormone (CRH) circuits in the developing rat: effect of maternal deprivation.

发育中大鼠的脑促肾上腺皮质激素释放激素（CRH）回路：母亲剥夺的影响。

DOI：
10.1016/j.brainres.2006.08.104
发表时间：
2006
期刊：
Brain research
影响因子：
2.9
作者：
Vazquez,DeliaM;Bailey,Charles;Dent,GershamW;Okimoto,DarrenK;Steffek,Amy;López,JuanF;Levine,Seymour
通讯作者：
Levine,Seymour

Differential expression of c-fos and tyrosine hydroxylase mRNA in the adrenal gland of the infant rat: evidence for an adrenal hyporesponsive period.

幼鼠肾上腺中 c-fos 和酪氨酸羟化酶 mRNA 的差异表达：肾上腺低反应期的证据。

DOI：
10.1210/endo.143.5.8819
发表时间：
2002
期刊：
Endocrinology.
影响因子：
0
作者：
Okimoto,DarrenK;Blaus,Alison;Schmidt,MathiasV;Schmidt,Mathias;Gordon,MKathleen;Dent,GershamW;Levine,Seymour
通讯作者：
Levine,Seymour

Maternal regulation of adrenocortical activity in the infant rat: effects of feeding.