DETECTABILITY IN BRAIN ACTIVATION STUDIES

大脑激活研究中的可检测性

• 批准号: 2416381
• 负责人: Chin-Tu Chen
• 金额: $ 23.08万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-25 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2416381
• 关键词: blood flow measurement; brain electrical activity; cerebrovascular imaging /visualization; computational neuroscience; computer program /software; computer simulation; computer system design /evaluation; data collection methodology /evaluation; human data; image processing; mathematical model; model design /development; positron emission tomography

DESCRIPTION (Adapted from Applicant's Abstract): The objective of the proposed research is to investigate the factors affecting the detectability and characterization of brain activation, and thus develop guidelines for designing activation studies and interpreting their results. The quantitative results of the proposed experiments will be plots of receiver operator characteristic (ROC) curves and related detectability parameters as well as the bias and variance measurements of activation site size under various experimental conditions. A software package will be developed for general distribution that will allow researchers to determine the operating characteristics obtainable under their unique experimental conditions. This will facilitate the design and interpretation of the results of their studies. The proposed studies will define the limits and probe the potential of what can realistically be measured in current brain-activation studies. The studies will indicate the experimental conditions for successful detection an the relative sensitivity of the results to the experimental parameters. The quantitative results produced will provide the data required for selecting decision thresholds, and for evaluating error probabilities in the detection tasks. Finally the proposed studies are expected to reveal weaknesses in the methodologies that may suggest fruitful research toward refining this potentially powerful approach to understanding the workings, and disease processes, of the human brain. The primary tool in the investigations will be computer simulation of brain-activation studies, which will enable various elements of the methodology to be studied in a controlled manner.

描述（根据申请人的摘要改编）： 拟议的研究是研究影响可检测性的因素 和大脑激活的表征，从而为 设计激活研究并解释其结果。 这 提出的实验的定量结果将是接收器的图 操作员特征（ROC）曲线和相关可检测性参数 以及激活位点大小的偏差和方差测量 各种实验条件。 将开发一个软件包 一般分布，将使研究人员能够确定操作 在其独特的实验条件下可获得的特征。 这 将促进其结果的设计和解释 研究。 拟议的研究将定义限制并探测 在当前的脑激活中可以实际测量的东西的潜力 研究。 研究将指示 成功检测结果对 实验参数。 产生的定量结果将提供 选择决策阈值所需的数据和评估错误 检测任务中的概率。 最后，提出的研究是 有望在方法论中揭示弱点，这些弱点可能暗示 研究这种潜在强大的理解方法 人脑的起作用和疾病过程。 主要工具 在调查中，将是计算机模拟脑激活 研究，这将使方法的各种要素进行研究 以受控的方式。