Neural-Electromagnetic-Hemodynamic Links in Humans

人类的神经-电磁-血流动力学联系

• 批准号: 6611644
• 负责人: Eric Halgren
• 金额: $ 38.01万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6611644
• 关键词: bioimaging /biomedical imaging; blood flow measurement; brain circulation; brain electrical activity; brain imaging /visualization /scanning; cerebrovascular imaging /visualization; clinical research; computational neuroscience; electroencephalography; functional magnetic resonance imaging; human subject; magnetoencephalography; microelectrodes; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): The spatiotemporal dynamics of human brain activation can be non-invasively imaged by combining functional Magnetic Resonance Imaging (fMRI) with magneto- and electro-encephalography (M/EEG). fMRI locates altered cerebral hemodynamics with good spatial accuracy but poor temporal resolution. Conversely, M/EEG are instantaneous measures of population synaptic activity, but are hard to localize because of spatiotemporal cancellation. Furthermore, the transfer functions from cortical neuronal synaptic currents and cell-firing, to extracranial hemodynamic and electromagnetic signals, are unknown. The potential variability of the relationships of hemodynamic and electromagnetic signals to each other, and to their underlying neural substrates, make it necessary to explore and define these relations in behaving humans. We propose to measure neuronal activity using linear arrays of micro-electrodes. Optical measurements will quantify hemodynamics using cortical point spectroscopy and laser Doppler. Simultaneous measures within the same cortical micro-domain will be made during spontaneous activity, calibration states, and a variety of cognitive tasks. If successful, this research will reveal, at an unprecedented level of quantification and certainty, the relations between hemodynamic and electromagnetic measures, and the underlying activity of neuronal populations, during cognition in humans.

描述（由申请人提供）： 人脑激活的时空动力学可以通过将功能性磁共振成像（fMRI）与磁磁和电脑摄影（M/EEG）相结合，从而无创地成像。 fMRI以良好的空间精度定位了改变的大脑血流动力学，但时间分辨率较差。相反，M/EEG是人口突触活动的瞬时测量，但由于时空取消，很难定位。此外，从皮质神经元突触电流和细胞传感器到颅外血液动力学和电磁信号的转移功能尚不清楚。血液动力学和电磁信号之间关系的潜在变异性彼此之间以及其潜在的神经底物的潜在变化使得有必要在行为人类中探索和定义这些关系。我们建议使用微电极的线性阵列测量神经元活性。光学测量将使用皮质点光谱和激光多普勒来量化血液动力学。在自发活动，校准状态和多种认知任务中，将在同一皮质微识别范围内同时进行衡量。如果成功的话，这项研究将在人类认知期间的量化和确定性水平，血液动力学和电磁措施之间的关系以及神经元种群的潜在活性以前所未有的水平揭示。