Automated monitoring of MRI abnormalities in HIV/AIDS

自动监测 HIV/AIDS MRI 异常

• 批准号: 6841866
• 负责人: Eric Halgren
• 金额: $ 30.68万
• 依托单位: CORTECHS LABS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6841866
• 关键词: AIDS; AIDS dementia complex; HIV infections; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain morphology; clinical research; computer assisted patient care; computer program /software; computer system design /evaluation; human data; image guided surgery /therapy; magnetic resonance imaging; neuropathology; neuropsychology; patient care management; patient oriented research

DESCRIPTION (provided by applicant): Neuropsychological problems are common in Human Immunodeficiency Virus infection (HIV) and Acquired Immune Deficiency Syndrome (AIDS), even in the absence of clearly visible cerebral lesions. In many cases, the origin of these problems in cerebral function is confounded by other issues, such as medication interactions, substance abuse, or emotional reaction to this devastating illness. Research using hand-delineation of cerebral structures suggests that specific neuropsychological problems are associated with decreased volume of the caudate nucleus. However, the expertise and time required to perform these manual measurements severely limit their application in clinical trials, and prevent them from being used in clinical practice. The overall goal of this project is to develop MRI-analysis software that can automatically and accurately quantify cerebral structures in patients with HIV/AIDS The outcome of this project will be commercialized as an HIV image-processing service for clinical trials and as medical device software providing HIV specific quantification. In a pharmacological research setting, the proposed software will allow non-invasive monitoring of cerebral status, thus providing objective criteria for developing treatment approaches to arrest or prevent AIDS dementia. In the clinical setting, the cerebral quantification provided by this software may eventually be applied to the selection of patients for treatment, and in the monitoring of treatments. Our first specific aim is to optimize our cerebral segmentation and quantification software for subjects with HIV/AIDS. Our second aim is to optimize our cortical labeling and quantification software for subjects with HIV/AIDS. Our third aim is to develop software quantifying tissue property changes in normal appearing white matter of subjects with HIV infection using Diffusion Tensor Imaging. Our fourth aim is to validate the automatic cerebral quantification software against "gold standard" manual segmentation methods in subjects infected with HIV. Fulfillment of these specific aims will demonstrate the feasibility and accuracy of automatic cerebral quantification software for HIV disease monitoring.

描述（由申请人提供）：即使在没有明显可见的大脑病变的情况下，神经心理问题在人类免疫缺陷病毒感染（HIV）和获得的免疫缺陷综合征（AIDS）中也很常见。在许多情况下，这些问题在脑功能中的起源是由其他问题（例如药物相互作用，药物滥用或对这种毁灭性疾病的情感反应）混淆的。使用脑结构的手部限制的研究表明，特定的神经心理问题与尾状核的体积减少有关。但是，执行这些手动测量所需的专业知识和时间严重限制了它们在临床试验中的应用，并防止它们用于临床实践。该项目的总体目标是开发MRI分析软件，可以自动，准确地量化艾滋病毒/艾滋病患者的脑结构。该项目的结果将作为临床试验的HIV图像处理服务进行商业化，并作为提供HIV特定量化的医疗设备软件。在药理研究环境中，该提议的软件将允许对脑状况进行非侵入性监测，从而为开发逮捕或预防艾滋病痴呆的治疗方法提供客观标准。在临床环境中，该软件提供的大脑定量最终可能应用于患者的治疗和治疗监测。我们的第一个具体目的是为患有艾滋病毒/艾滋病的受试者优化我们的大脑细分和量化软件。我们的第二个目的是为患有艾滋病毒/艾滋病的受试者优化我们的皮质标签和量化软件。我们的第三个目的是使用扩散张量成像来开发软件，以量化HIV感染受试者的正常出现的组织特性变化。我们的第四个目标是验证自动脑定量软件，以感染HIV的受试者中的“金标准”手动分割方法。实现这些特定目的将证明自动脑定量软件用于HIV疾病监测的可行性和准确性。