VISUAL MOTION PROCESSING DURING OBSERVER MOVEMENT

观察者移动期间的视觉运动处理

• 批准号: 2711097
• 负责人: CHARLES J DUFFY
• 金额: $ 19.16万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2711097
• 关键词: Macaca mulatta; behavioral /social science research tag; body movement; brain electrical activity; motion perception; neural information processing; somesthesis; vestibuloocular reflex; visual cortex; visual perception; visual stimulus

Cerebral cortex lesions, at the junction of the posterior parietal and superior temporal areas, cause an incapacitating syndrome of visuospatial disorientation (Holmes, 1918). The fact that visual, vestibular, or somatosensory pathology may also disrupt spatial orientation suggests that these mechanisms are integrated into a multisensory percept of extrapersonal space, possibly within parietotemporal cortex. During self-movement, visual motion processing interacts with vestibular and somatosensory mechanisms to support spatial orientation. I propose to test whether parietotemporal neurons might contribute to those interactions by recording neuronal responses to visual and non-visual motion stimuli. The activity of single neurons in parietotemporal areas MSTd and 7A of awake monkeys will be recorded during visual motion simulations of the self-movement scene, during vestibular and somatosensory activation by passive linear movement. Three sets of experiments are planned to examine critical issues regarding neuronal responses and self-movement perception. First, I will compare the relative selectivity of these neurons for the patterned visual motion seen during observer movement (optic flow) and visual figure motion, which can result from observer or object movement. Second, I will record the responses of these neurons to linear self-movement in the dark and determine what contributions vestibular and somatosensory mechanisms might make to those responses. Third, I will combine visual motion with linear self-movement to define the dynamics of multisensory interactions in these neurons. These studies will test the capacity of MSTd and 7A neurons to integrate visual, vestibular and somatosensory information during self-movement. My goal is to characterize their potential contributions to spatial vision, locomotor, and oculomotor control. The results will be relevant to understanding central mechanisms which serve fundamental behavioral capacities such as the stabilization of gain and gaze, and the maintenance of spatial orientation. In addition, the results will provide a basic understanding of how spatial vision might interact with the vestibular and somatosensory systems to maintain postural control in health, disease, and aging.

大脑皮层病变，位于后顶叶和后顶叶交界处 颞上区，导致视觉空间失能综合征 迷失方向（Holmes，1918）。 事实上，视觉、前庭或 体感病理学也可能破坏空间定向 这些机制被整合到多感官知觉中 个人空间，可能位于顶颞叶皮层内。 期间 自我运动，视觉运动处理与前庭和 支持空间定向的体感机制。 我建议 测试顶颞神经元是否可能有助于这些 通过记录神经元对视觉和非视觉的反应来进行相互作用 运动刺激。 顶颞区 MSTd 和 7A 单个神经元的活动 清醒的猴子将在视觉运动模拟过程中被记录下来 前庭和体感激活期间的自我运动场景 被动线性运动。 计划进行三组实验 检查有关神经元反应和自我运动的关键问题 洞察力。 首先，我将比较这些的相对选择性 观察者运动期间看到的图案化视觉运动的神经元 （光流）和视觉图形运动，可以由观察者或 物体运动。 其次，我会记录这些神经元的反应 在黑暗中进行线性自我运动并确定哪些贡献 前庭和体感机制可能会对这些反应做出反应。 第三，我将把视觉运动和线性自运动结合起来来定义 这些神经元中多感觉相互作用的动态。 这些研究将测试 MSTd 和 7A 神经元整合的能力 自我运动过程中的视觉、前庭和体感信息。 我的目标是描述它们对空间的潜在贡献 视力、运动和动眼神经控制。 结果将是相关的 理解服务于基本行为的中心机制 能力，例如增益和凝视的稳定，以及 空间定向的维持。 此外，结果将 提供对空间视觉如何与 前庭和体感系统维持姿势控制 健康、疾病和衰老。