ANTITUMOR FIJIAN SPONGE DERIVED KETIDE AMINO ACIDS

抗肿瘤斐济海绵衍生的酮基氨基酸

• 批准号: 2695500
• 负责人: Phil Crews
• 金额: $ 2.49万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2695500
• 关键词: Pacific Islands; Porifera; aminoacid analog; animal extract; antineoplastics; aquatic organism; chemical structure; ecology; field study

DESCRIPTION: The biologically important marine sponge Jaspis coriacea is common throughout the Indo-Pacific and is especially abundant in Fiji reefs. The bengamide family of ketide-amino acids are the predominant secondary metabolites of J. coriacea, and several such analogs are presently a high priority of the parent NCNPDDG grant U19CA52955 because of their cytotoxicity against MDA-435 breast tumor cells. This FIRCA will assist the effort to examine J. coriacea and the bengamides in greater detail. Previous work has established that distribution of the types of bengamides found in J. coriacea samples appears to vary with the season and with the geographical location of the sponges. Although this variability is established, the factors that cause it are not understood. The research proposed will examine the chemical variation of the bengamides in J. coriacea as a function of ecological factors.

描述： 具有重要生物学意义的海洋海绵 Jaspis coriacea 很常见 遍布印度洋-太平洋地区，在斐济的珊瑚礁中尤其丰富。这 酮化合物氨基酸苯甲酰胺家族是主要的次要氨基酸 J. coriacea 的代谢物和几种此类类似物目前是高 父NCNPDDG赠款U19CA52955的优先级，因为它们 针对 MDA-435 乳腺肿瘤细胞的细胞毒性。该 FIRCA 将协助 更详细地研究 J. coriacea 和苯甲酰胺的努力。 先前的工作已确定苯甲酰胺类型的分布 J. coriacea 样本中发现的变化似乎随季节和环境的变化而变化。 海绵的地理位置。尽管这种变化是 已成立，但造成该现象的因素尚不清楚。研究 提议将检查 J 中苯甲酰胺的化学变化。 Coriacea 作为生态因素的函数。