STRUCTURE AND CONFORMATION OF NOVEL ANTITUMOR AGENTS FROM MARINE ANIMALS

海洋动物新型抗肿瘤剂的结构和构象

基本信息

批准号：
6430866
负责人：
Phil Crews
金额：
$ 28.24万
依托单位：
UNIVERSITY OF CALIFORNIA SANTA CRUZ
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-04-01 至 2002-03-31
项目状态：
已结题

项目摘要

This project deals with the discovery of unique marine natural products that may provide leads for the development of anti-cancer agents. Our continuing overall objective is to obtain compounds both fundamentally new molecular structures and potential in anticancer drug development. To effectively address such a broad goal requires a collaborative effort between marine natural products chemistry, cell biology and organism biology. All of these elements are present in the experimental design and in the available facilities. Indo-Pacific marine sponges (sometimes collected by MBRS student participants) are the initial materials used in this research and they are chosen from taxonomic groups that have not been well studied. Their crude extracts are being investigated by a bioassay guided approach. Once compounds are isolated they are characterized by extensively study using such powerful spectroscopic methods as multi-dimensional Nuclear Magnetic Resonance. Each MBRS student will have the option of joining one of three funded, on-going projects. The goal in this MBRS component is to expose students to the major interests of our laboratory including organic structure analysis, elucidation biosynthetic pathways, and uncovering relationships between patterns of organic structure and the phyletics of their organism source. MBRS students interested in biology, biochemistry, or bioorganic chemistry can participate. Students first learn how to organize and track experiments where the correct interpretation of initial results dictates the follow-up experiments. A parallel effort involves learning logical approaches using state-of-the-art NMR methods to solve complex problems of molecular structure analysis and determination of stereochemistry relationships. Another intent is to provide situations where research results can be compared to information obtained from both the biological and chemistry literature to derive new insights about biosynthesis or chemotaxonomy.

该项目涉及发现独特的海洋天然产品这可能为抗癌代理的发展提供潜在客户。我们的持续的总体目标是从根本上获得化合物新的分子结构和抗癌药物开发的潜力。为了有效解决这样的广泛目标，需要协作努力海洋天然产品化学，细胞生物学和生物体之间生物学。所有这些元素都存在于实验设计中并在可用的设施中。印度太平洋海洋海绵（有时由MBRS学生参与者收集的）是使用的初始材料在这项研究中，它们是从没有的分类群体中选择的经过深入研究。他们的原油提取物正在研究生物测定指导方法。一旦化合物孤立，它们是使用如此强大的光谱学进行了广泛的研究来表征方法作为多维核磁共振。每个MBRS学生都可以选择加入三个资助的一个，正在进行的项目。该MBRS组件的目标是揭露学生为了我们实验室的主要利益，包括有机结构分析，阐明生物合成途径和发现关系在有机结构的模式与其生物体的植物学之间来源。对生物学，生物化学或生物有机感兴趣的MBRS学生化学可以参与。学生首先学习如何组织和跟踪实验，在其中正确解释初始结果决定后续实验。平行的努力涉及学习使用最先进的NMR方法解决复杂的逻辑方法分子结构分析和确定的问题立体化学关系。另一个目的是提供情况可以将研究结果与从两者获得的信息进行比较的地方生物学和化学文献获得了有关的新见解生物合成或趋化性。