Engineering Hybrid Materials with Functional Bioactivity in the GI Tract

在胃肠道中具有功能性生物活性的工程混合材料

• 批准号: LP230100345
• 负责人: Prof Clive Prestidge
• 金额: $ 31.88万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP230100345
• 关键词: Engineering; Hybrid; Materials; Functional; Bioactivity

This project aims to use an advanced particle engineering approach to develop novel biomaterials with multifunctional activities in the gastrointestinal tract. The project expects to generate new fundamental knowledge of the key interfacial processes that control digestion and identify new pathways for modulating gut microbiome composition. By establishing structure-activity relationships through mechanistic in vitro and in vivo models, the knowledge gain will help guide material design for optimised bioactivity. Technology transfer of the lead formulation through quality by design manufacturing practice is anticipated to position the industry partner for future commercial opportunities within the nutraceutical sector.

该项目旨在利用先进的粒子工程方法来开发在胃肠道中具有多功能活性的新型生物材料。该项目期望产生控制消化的关键界面过程的新基础知识，并确定调节肠道微生物组组成的新途径。通过机械体外和体内模型建立结构-活性关系，获得的知识将有助于指导材料设计以优化生物活性。通过质量源于设计的制造实践进行先导制剂的技术转让，预计将为行业合作伙伴在营养保健品领域的未来商业机会中定位。