Targeting particulate carriers to epithelial M cells

将颗粒载体靶向上皮 M 细胞

• 批准号: LP150100032
• 负责人: Prof Clive Prestidge
• 金额: $ 27.59万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-12-15 至 2019-09-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150100032
• 关键词: Targeting; particulate; carriers; epithelial; cells

This project aims to develop and validate an advanced in vitro model of the human intestinal epithelium. The intestine-on-chip model should enable mechanistic studies of the uptake of nano- and micron-size particles by intestinal cells and deliver new insights into the way particulate carriers can be specifically targeted and transported across the intestinal epithelium. Project knowledge and technology are anticipated to generate new commercialisation opportunities in the oral delivery industry and ultimately, should drive the development of efficient oral formulations for biologics. The model should also reduce the need for animal studies.

该项目旨在开发和验证人类肠上皮的先进体外模型。片上的肠模型应通过肠细胞对纳米和微米大小的颗粒的摄取，并对颗粒载体的方式进行特定靶向和运输的方式来实现机械研究。预计项目知识和技术将在口头递送行业中产生新的商业化机会，最终应推动生物制剂有效的口服配方的开发。该模型还应减少对动物研究的需求。