Targeting particulate carriers to epithelial M cells

将颗粒载体靶向上皮 M 细胞

• 批准号: LP150100032
• 负责人: Prof Clive Prestidge
• 金额: $ 27.59万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-12-15 至 2019-09-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150100032
• 关键词: Targeting; particulate; carriers; epithelial; cells

This project aims to develop and validate an advanced in vitro model of the human intestinal epithelium. The intestine-on-chip model should enable mechanistic studies of the uptake of nano- and micron-size particles by intestinal cells and deliver new insights into the way particulate carriers can be specifically targeted and transported across the intestinal epithelium. Project knowledge and technology are anticipated to generate new commercialisation opportunities in the oral delivery industry and ultimately, should drive the development of efficient oral formulations for biologics. The model should also reduce the need for animal studies.

该项目旨在开发和验证先进的人类肠上皮体外模型。肠芯片模型应该能够对肠细胞吸收纳米和微米尺寸颗粒的机制进行研究，并为颗粒载体如何特异性靶向并穿过肠上皮运输提供新的见解。预计项目知识和技术将在口服给药行业产生新的商业化机会，并最终推动生物制剂高效口服制剂的开发。该模型还应该减少对动物研究的需求。