MATURATION AND PLASTICITY IN THE OLFACTORY SYSTEM

嗅觉系统的成熟和可塑性

• 批准号: 2014369
• 负责人: PETER C BRUNJES
• 金额: $ 10.97万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2014369
• 关键词: afferent nerve; autoradiography; behavioral /social science research tag; biological signal transduction; cell death; cell population study; chemoreceptors; developmental neurobiology; early experience; gene expression; immunocytochemistry; laboratory rat; limbic system; neural plasticity; neuroanatomy; newborn animals; olfactory lobe; olfactory stimulus; protein biosynthesis; regulatory gene; sensory deprivation

DESCRIPTION (Adapted from the Investigator's Abstract): The experiments proposed examine the development of the receptors and primary central relays in the olfactory system. The olfactory system has many desirable characteristics for studies of the mechanisms of neural maturation. It is highly organized, with clear lamination and a well-studied wiring diagram, facilitating quantitative examinations and making subtle alterations relatively easy to discern. Furthermore, many interesting forms of early plasticity have been demonstrated, including substantial sensitivity to early manipulations of either the type or amount of odor stimuli available. For example, early unilateral odor deprivation has been repeatedly demonstrated to result in some of the largest experience-induced changes observed in the central nervous system. The principal investigator and colleagues have been involved in studying the cascade of changes induced by functionally depriving the olfactory system in order to understand how early brain function directs normal brain maturation. The proposed research continues the quantitative examination of the sequential developmental changes occurring in normal and functionally restricted animals. Specifically, the principal investigator proposes to examine: 1) Rapid changes that occur in the olfactory bulb when the amount of odorant stimulation is abruptly decreased. Examinations will focus on rapid regulation of genomic expression and protein synthesis to identify which cell populations respond to afferent manipulations. 2) The effects of brief intervals of sensory restriction on the growth of the bulb. Reversible naris occlusion will be used to test signaling pathways in the bulb and to examine the possibility of recovery of normal growth patterns.

描述（根据调查员的摘要改编）：实验 拟议检查受体和主要中心的发展 嗅觉系统中的继电器。嗅觉系统具有许多理想的 研究神经成熟机制的特征。它 高度有条理，具有清晰的层压和良好的布线 图，促进定量检查并使微妙 改动相对容易辨别。此外，许多有趣 已经证明了早期可塑性的形式，包括实质性 对早期操纵的敏感性 可用的刺激。例如，早期的单侧气味剥夺具有 反复证明会导致一些最大的 经验引起的中枢神经系统观察到的变化。这 首席研究员和同事参与了研究 通过功能剥夺嗅觉而引起的变化的级联 系统以了解早期功能如何指导正常 大脑成熟。拟议的研究继续定量 检查正常的顺序发展变化 并在功能上受到限制的动物。具体来说，校长 研究者建议检查：1）在 当气味刺激的量突然时，嗅球 减少。检查将集中于基因组的快速调节 表达和蛋白质合成以识别哪些细胞群 响应传入的操纵。 2）短时的效果 对灯泡生长的感觉限制。可逆的纳里斯 闭塞将用于测试灯泡中的信号通路和 检查正常生长模式恢复的可能性。