ETHANOL ADMINISTRATION AND MOTOR FUNCTIONS

乙醇管理和运动功能

• 批准号: 2389930
• 负责人: DONALD JAY WOODWARD
• 金额: $ 23.21万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2389930
• 关键词: action potentials; alcoholic beverage consumption; behavioral /social science research tag; behavioral extinction; behavioral habituation /sensitization; dopamine; ethanol; frontal lobe /cortex; gamma aminobutyrate; histology; laboratory rat; limbic system; microelectrodes; motor neurons; neuroanatomy; neurophysiology; neurotransmitters; nucleus accumbens; operant conditionings; performance; reinforcer; self medication; tegmentum

A program of studies will be conducted to examine actions of ethanol on brain regions related to self-administration of ethanol and to sensory motor integration. Rats will be used as experimental models to study the activity of neurons which cause the behavioral task sequencing related to operant control of ethanol self-administration. The influence of sensory cues will be studied on the initiation maintenance and termination of a drinking 'bout'. Newly developed concurrent many-neuron recording techniques will be employed which utilize groups of chronically implanted microwires for neuron spike train detection and statistical/graphical analysis. Neuron recording will be conducted primarily in the mesolimbic system including the media prefrontal cortex subregions of the nucleus accumbens and the dopamine and nondopamine neurons of the ventral tegmental area. Neuron signals will be studied in relation to similar motor tasks leading to alternate rewards of ethanol or sucrose solution. Influence of ethanol on a tone cue reaction time task will be studied. This neurophysiological analysis of behavioral control will provide new insights into possible avenues for therapeutic regulation of ethanol consumption.

将开展一项研究计划来检验乙醇对 与自我施用乙醇和感觉相关的大脑区域 电机集成。将使用大鼠作为实验模型来研究 引起行为任务排序相关的神经元活动 乙醇自我施用的操作控制。的影响 将研究感官线索的启动维持和 终止饮酒“回合”。新开发的并发多神经元 将采用记录技术，利用长期的群体 植入微线用于神经元尖峰序列检测和 统计/图形分析。将进行神经元记录 主要存在于中脑边缘系统，包括中前额皮质 伏隔核以及多巴胺和非多巴胺的亚区域 腹侧被盖区的神经元。神经元信号将被研究 与导致乙醇替代奖励的类似运动任务的关系 或蔗糖溶液。乙醇对音调提示反应时间的影响 任务将被研究。这种行为的神经生理学分析 控制将为可能的治疗途径提供新的见解 乙醇消费的监管。