DISCONTIGUOUS ARRAY DETECTOR FOR DIGITAL MAMMOGRAPHY

用于数字乳房X线照相术的不连续阵列探测器

• 批准号: 2429879
• 负责人: MARK B WILLIAMS
• 金额: $ 49.51万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2429879
• 关键词: biomedical equipment development; breast neoplasm /cancer diagnosis; charge coupled device camera; clinical biomedical equipment; clinical research; diagnosis design /evaluation; digital imaging; early diagnosis; image enhancement; mammography; phantom model; women's health

Breast cancer is the most common cancer of American women and the leading cause of cancer-related death among women aged 15-54. Early detection of breast cancer through mammography can lead to a high probability of cure. However, because of several inherent limitations of film as a recording device for the mammographic image, conventional screen-film mammography is limited in its ability to detect subtle cancers, especially in patients with radiodense breast tissue. Digital mammography offers a means of overcoming these limitations. This application's overall objective is the transfer of the successful results of more than 10 years of research on the development and evaluation of high resolution CCD detectors for macromolecular crystallography to digital mammography, resulting in a modular, scalable, high performance system for full breast imaging. The project is a collaborative effort between the University of Virginia Health Sciences Center and the Rosenstiel Center at Brandeis University. The proposed mammographic detector, based on a proven design and comprised of components whose manufacture is well within current commercial fabrication capabilities, will provide sensitivity and resolution exceeding that projected for full breast systems currently under development by several equipment manufacturers. The full detector will be composed of an array of detector modules, each of which contains an X-ray phosphor deposited directly onto a fiber optic taper, which is in turn bonded to a CCD array. The detector will provide a digital alternate to analog screen/film systems, exhibiting higher detective quantum efficiency (DQE), a larger dynamic range, superior linearity, and near realtime readout. Because of its higher DQE and low noise, the proposed detector will enable quantum-limited operation over a larger range of X-ray fluence than do current screen/film systems, thereby allowing reduced glandular dose for the same image quality. Specific developmental tasks are as follows: TASK 1: Basic performance characteristics of a single module under mammographic conditions will be measured. Characteristics to be measured will include gain, sensitivity, and the system modulation transfer function (MTF), noise power spectrum (NPS), and DQE as a function of spatial frequency. TASK 2: Software for data acquisition and display, and algorithms for correction of geometric distortion and nonuniformity of detection efficiency for images from a single module will be developed. TASK 3: Composite images formed from multiple single module subimages will be evaluated. Basic imaging characterization will be performed on the composite images, with particular attention to image quality at the subimage boundaries. TASK 4: The diagnostic imaging capability of the multi-module detector will be evaluated through ROC analysis, comparing the imaging capabilities of the CCD array detector with those of the screen-film systems currently in use at the UVa Diagnostic Center for Women. TASK 5: During the third year, a 4-module (24 cm x 24 cm) clinical prototype array detector will be constructed, using the optimized module design. TASK 6: The basic and diagnostic imaging properties of the clinical prototype detector will be evaluated, as described above.

乳腺癌是美国女性最常见的癌症，也是主要癌症 15-54 岁女性癌症相关死亡的原因。 及早发现 通过乳房X线摄影检查乳腺癌的治愈率很高。 然而，由于胶片作为记录材料的一些固有局限性 用于乳腺X线摄影图像的装置，传统的屏幕胶片乳腺X线摄影是 其检测细微癌症的能力有限，尤其是患者的癌症 具有放射致密乳腺组织。 数字乳房X线摄影提供了一种方法 克服这些限制。 该应用程序的总体目标是成功转移 10多年的研发和研究成果 高分子高分辨率CCD探测器的评价 晶体学到数字乳腺X线摄影，从而形成模块化、可扩展、 用于全乳腺成像的高性能系统。 该项目是一个 弗吉尼亚大学健康科学学院之间的合作 中心和布兰迪斯大学罗森斯蒂尔中心。 所提议的乳腺X光检测器基于经过验证的设计，包括 其制造完全符合当前商业化的组件 制造能力，将提供灵敏度和分辨率 超过目前对全乳系统的预测 由多家设备制造商开发。 完整的探测器将是 由探测器模块阵列组成，每个模块包含一个 X 射线 荧光粉直接沉积到光纤锥体上，进而 粘合到 CCD 阵列上。 该探测器将提供数字替代 模拟屏幕/电影系统，表现出更高的侦探量子效率 (DQE)、更大的动态范围、卓越的线性度和近实时性 读出。 由于其较高的 DQE 和低噪声，所提出的检测器 将在更大范围的 X 射线注量上实现量子限制操作 比当前的屏幕/电影系统，从而减少腺体 相同图像质量的剂量。 具体发展任务如下 如下： 任务1：单个模块的基本性能特征 将测量乳房X线照相条件。 待测特性 将包括增益、灵敏度和系统调制传输 函数 (MTF)、噪声功率谱 (NPS) 和 DQE 作为函数 空间频率。 任务 2：数据采集和显示软件，以及 用于校正几何畸变和不均匀性的算法 将开发来自单个模块的图像的检测效率。 任务 3：由多个单模块子图像形成的复合图像将 进行评估。 基本成像特征将在 合成图像，特别注意图像质量 子图像边界。 任务 4：诊断成像能力 多模块探测器将通过ROC分析进行评估，比较 CCD阵列探测器的成像能力与 UVa 诊断中心目前使用的屏幕胶片系统 女性。 任务 5：在第三年，进行 4 模块（24 厘米 x 24 厘米）临床 将使用优化的模块构建原型阵列探测器 设计。 任务 6： 的基本和诊断成像特性 如上所述，将评估临床原型探测器。