Core--Small Animal Imaging

核心--小动物影像

• 批准号: 6946744
• 负责人: MARK B WILLIAMS
• 金额: $ 11.72万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-16 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946744
• 关键词: X ray; bioimaging /biomedical imaging; bioluminescence; biomedical facility; gamma radiation; imaging /visualization /scanning; inflammation; laboratory mouse; laboratory rat; lung injury; magnetic resonance imaging

The Small Animal Imaging Core will be run by the UVA Small Animal Multimodality Imaging Core (SAMMIC) and will provide resources for in vivo imaging of mice and rats for investigators in this Program Project Grant (PPG). The Core will be an enhancement of the existing SAMMIC, that will provide dedicated imaging services to PPG participants. As such, several imaging modalities will be available to PPG investigators, including dual modality x-ray/gamma ray scanning, high resolution MRI, and bioluminescence imaging. The responsibilities of the Core will include: a) providing expertise to investigators regarding the selection of appropriate imaging modality, scanning protocol, tracer selection etc. b) coordination of the various components and personnel associated with the imaging procedure such as radioisotope suppliers, radiochemists, vivarium personnel, SAMMIC technicians, and UVa organizations such as the Office of Environmental Health and Safety and the Animal Research Committee c) supervising actual operation of the scanners, and d) working with investigators as requested on analysis of the image data. In addition, the Core members will be responsible for oversight of imaging quality control issues, laboratory radiation safety issues, and image processing and analysis software development.

小动物成像核心将由 UVA 小动物多模态成像核心 (SAMMIC) 运行，并将为本计划项目拨款 (PPG) 的研究人员提供小鼠和大鼠体内成像资源。该核心将是现有 SAMMIC 的增强，将为 PPG 参与者提供专门的成像服务。因此，PPG 研究人员将可以使用多种成像方式，包括双模态 X 射线/伽马射线扫描、高分辨率 MRI 和生物发光成像。核心的职责包括： a) 为研究者提供有关选择适当成像方式、扫描方案、示踪剂选择等方面的专业知识。 b) 协调与成像程序相关的各个组成部分和人员，例如放射性同位素供应商、放射化学家、动物饲养室人员、SAMMIC 技术人员和 UVa 组织（例如环境健康与安全办公室和动物研究委员会） c) 监督扫描仪的实际操作，以及 d) 根据要求与调查人员合作分析图像数据。此外，核心成员将负责监督成像质量控制问题、实验室辐射安全问题以及图像处理和分析软件开发。