Application of Breast Imaging Techn to Molecular Imaging

乳腺影像技术在分子影像中的应用

基本信息

批准号：
6615637
负责人：
MARK B WILLIAMS
金额：
$ 37万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-06-01 至 2007-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6615637
关键词：
bioimaging /biomedical imaging biomedical equipment development computed axial tomography computer program /software computer system design /evaluation mammography phantom model single photon emission computed tomography

项目摘要

DESCRIPTION (Provided by Applicant): Medical research is entering an era in which the key advancements in our understanding of the origin and nature of disease will occur primarily at the molecular and genetic level. Medical imaging technologies will play an important role by enabling us to follow these processes in the context of the live organism. Because its genetic profile is now well understood and can be manipulated, the mouse provides a powerful tool for modeling a variety of human diseases. Important areas of investigation include localization and quantification of gene expression, identification of cancer metastasis, longitudinal evaluation of therapeutic protocols, characterization of phenotype in transgenic mice, and understanding of the biodistribution and efficacy of new pharmaceuticals. However, new imaging devices with very high spatial resolution will be required for these tasks. In this proposed project, technologies developed during the previous funding period for breast imaging will be applied to the development of a dual modality tomograph for small animal research. The tomograph is designed to simultaneously acquire 3D x-ray transmission (CT) and 3D gamma emission (SPECT) data at high spatial resolution, thereby providing spatially and temporally coregistered structural and functional volumetric data. Our goal is to develop a unique tool for repeated, non-invasive measurement of cellular and molecular processes in small animals. The specific aims of the project are to: 1. Build an x-ray CT scanner using CCD-based x-ray detector modules optimized for fast readout and high spatial resolution 2. Build a pinhole SPECT system designed to minimize spatial resolution loss from pinhole penetration and from depth-of-interaction blurring effects 3. Develop software and design phantoms for calculation and empirical verification of multimodality spatial resolution, sensitivity, and acquisition time for various tomograph parameter values 4. Use mathematical and physical phantoms to evaluate 3D cone beam reconstruction techniques 5. Construct and characterize an integrated system, combining the CT and SPECT systems on a single gantry.

描述（由申请人提供）：医学研究正在进入我们对我们对起源和性质的理解的关键进步疾病将主要发生在分子和遗传水平。医疗的成像技术将通过使我们能够遵循这些角色发挥重要作用在活有机体的背景下进行过程。因为它的遗传特征是现在理解并可以操纵，鼠标提供了强大的工具用于建模各种人类疾病。重要调查领域包括基因表达的定位和定量，鉴定癌症转移，治疗方案的纵向评估，转基因小鼠表型的表征，并理解新药的生物分布和功效。但是，新成像这些任务需要具有很高空间分辨率的设备。在这个拟议的项目中，技术在先前的资金中发展乳房成像的时期将应用于双重方式的发展小型动物研究的断层扫描。层造影设计为同时获取3D X射线传输（CT）和3D Gamma发射（SPECT）高空间分辨率的数据，从而在空间和时间上提供核心结构和功能性容量数据。我们的目标是发展用于重复，非侵入性测量细胞和分子的独特工具小动物的过程。该项目的具体目的是： 1。使用基于CCD的X射线检测器模块构建X射线CT扫描仪快速读数和高空间分辨率 2。构建旨在最大程度减少空间分辨率损失的针孔SPECT系统来自针孔穿透和从深度相互作用模糊效果 3。开发用于计算和经验的软件和设计幻象验证多模式的空间分辨率，灵敏度和获取各种层压参数值的时间 4。使用数学和物理幻影评估3D锥束重建技术 5。构建和表征集成系统，结合CT和SPECT 单个龙门上的系统。