Application of Breast Imaging Techn to Molecular Imaging

乳腺影像技术在分子影像中的应用

基本信息

批准号：
6615637
负责人：
MARK B WILLIAMS
金额：
$ 37万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-06-01 至 2007-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6615637
关键词：
bioimaging /biomedical imaging biomedical equipment development computed axial tomography computer program /software computer system design /evaluation mammography phantom model single photon emission computed tomography

项目摘要

DESCRIPTION (Provided by Applicant): Medical research is entering an era in which the key advancements in our understanding of the origin and nature of disease will occur primarily at the molecular and genetic level. Medical imaging technologies will play an important role by enabling us to follow these processes in the context of the live organism. Because its genetic profile is now well understood and can be manipulated, the mouse provides a powerful tool for modeling a variety of human diseases. Important areas of investigation include localization and quantification of gene expression, identification of cancer metastasis, longitudinal evaluation of therapeutic protocols, characterization of phenotype in transgenic mice, and understanding of the biodistribution and efficacy of new pharmaceuticals. However, new imaging devices with very high spatial resolution will be required for these tasks. In this proposed project, technologies developed during the previous funding period for breast imaging will be applied to the development of a dual modality tomograph for small animal research. The tomograph is designed to simultaneously acquire 3D x-ray transmission (CT) and 3D gamma emission (SPECT) data at high spatial resolution, thereby providing spatially and temporally coregistered structural and functional volumetric data. Our goal is to develop a unique tool for repeated, non-invasive measurement of cellular and molecular processes in small animals. The specific aims of the project are to: 1. Build an x-ray CT scanner using CCD-based x-ray detector modules optimized for fast readout and high spatial resolution 2. Build a pinhole SPECT system designed to minimize spatial resolution loss from pinhole penetration and from depth-of-interaction blurring effects 3. Develop software and design phantoms for calculation and empirical verification of multimodality spatial resolution, sensitivity, and acquisition time for various tomograph parameter values 4. Use mathematical and physical phantoms to evaluate 3D cone beam reconstruction techniques 5. Construct and characterize an integrated system, combining the CT and SPECT systems on a single gantry.

描述（由申请人提供）：医学研究正在进入一个时代我们对生命起源和本质的理解取得了重大进展疾病主要发生在分子和基因水平。医疗的成像技术将发挥重要作用，使我们能够跟踪这些活有机体中的过程。因为它的遗传图谱是现在，鼠标已被很好地理解并且可以操作，它提供了一个强大的工具用于模拟多种人类疾病。重要调查领域包括基因表达的定位和定量、癌症转移、治疗方案的纵向评估、转基因小鼠表型的表征以及对新药物的生物分布和功效。然而，新的成像这些任务需要具有非常高空间分辨率的设备。在这个拟议的项目中，在先前的资助期间开发的技术乳腺成像时期将应用于双模态的开发用于小动物研究的断层扫描仪。断层扫描仪的设计目的是同时采集 3D X 射线透射 (CT) 和 3D 伽马发射 (SPECT) 高空间分辨率的数据，从而提供空间和时间共同注册的结构和功能体积数据。我们的目标是发展用于重复、非侵入性地测量细胞和分子的独特工具小动物的过程。该项目的具体目标是： 1. 使用优化的基于 CCD 的 X 射线探测器模块构建 X 射线 CT 扫描仪用于快速读出和高空间分辨率 2. 构建针孔 SPECT 系统，旨在最大限度地减少空间分辨率损失来自针孔穿透和交互深度模糊效果 3. 开发软件并设计模型进行计算和实证验证多模态空间分辨率、灵敏度和采集各种断层扫描参数值的时间 4. 使用数学和物理模型来评估 3D 锥形束重建技术 5. 结合 CT 和 SPECT 构建并表征集成系统单个龙门架上的系统。