COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER

人格障碍的合作纵向研究

• 批准号: 2379227
• 负责人: JOHN G GUNDERSON
• 金额: $ 20.97万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2379227
• 关键词: avoidance behavior; behavioral /social science research tag; clinical research; comorbidity; cooperative study; diagnosis design /evaluation; functional ability; health care service evaluation; health care service utilization; human subject; human therapy evaluation; interview; longitudinal human study; major depression; mental disorder chemotherapy; mental disorder diagnosis; obsessive compulsive disorder; personality disorders; prognosis; psychometrics; questionnaires; schizoid personality; young adult human (21-34)

The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPD) avoidant (AVPD) and obsessive- compulsive (OCPD). Using a prospective longitudinal, repeated measures design we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders. The absence of comparable data for individuals diagnosed with PDs represents an important gap in knowledge. To accomplish our overall aim we propose three approaches: I. descriptive, II. predictive, and III. validating. The descriptive approach will provide the basic data on stability of psychopathology and social impairment that allows comparison between the PDs and to similar data from Axis I disorders. The predictive approach will yield basic clinical insights into the determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs as defined by the DSM system and how this compares with alternative schemes. To accomplish these aims, this proposal requests funds to recruit rigorously assess, and follow a total sample of 750 subjects, aged 18 to 45, i.e., 150 of each of the four PDs and 150 controls with major depressive disorder (MDD) . The sample will be large enough and sufficiently diverse ethnically to attain results generalizable to most clinical settings and to examine the application of several dimensional approaches.

这项研究的总体目的是提供有关 四种特定人格障碍（PD）的课程和结果： 精神分裂（STPD），边界（BPD）回避（AVPD）和痴迷 - 强迫性（OCPD）。使用前瞻性纵向，重复措施 设计我们将发展有关课程和结果的相同基本知识 对于以前因对 情感和焦虑症。缺乏可比的数据 被诊断为PDS的人代表了知识的重要差距。 为了实现我们的整体目标，我们提出了三种方法：I。 描述性，ii。预测性和III。验证。描述性 方法将提供有关心理病理稳定性和的基本数据 社会障碍允许PD和类似的PDS进行比较 来自轴I疾病的数据。预测方法将产生基本 临床见解对跨越预后的决定因素 PDS。验证方法将检查描述性的同质性 DSM系统定义的PD的纵向特征和 这与替代方案的比较。 为了实现这些目标，该提案要求资金招募 严格评估，并遵循750名受试者的总样本，年龄在18岁至 45，即四个PD和150个对照中的150个， 抑郁症（MDD）。样本将足够大， 在种族上足够多样化，以达到大多数可概括的结果 临床设置并检查几个维度的应用 方法。