Family Study of Personality Traits and Their Relationship to Psychiatric Disorder

人格特质及其与精神疾病关系的家庭研究

基本信息

批准号：
7660484
负责人：
JOHN G GUNDERSON
金额：
$ 49.89万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-05 至 2010-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The primary aim of the proposed study is to test whether Borderline Personality Disorder (BPD) is familial (i.e., whether BPD in probands is associated with BPD in first degree relatives). The second aim of the proposed study is to test whether three component phenotypic personality traits (affective instability, behavioral dyscontrol, and interpersonal instability), are themselves familial. Each of these traits is a potentially relevant disposition for BPD as well as a variety of other psychiatric disorders. Both aims will provide results that will inform our classification system and provide leads for future genetic research. The proposed study will give direct and blinded assessments to 280 probands and 984 first degree relatives (3.5 per proband, 2.7 being direct). The probands will be comprised by 100 with borderline personality disorder (BPD), 80 with major depressive disorder (MOD), and by 100 non-borderline comparison subjects (NBC). The MDD and NBC samples will be demographically matched with the index BPD probands in gender (all female), age, and socio-ethnicity. The overall sampling strategy is intended to be sufficiently broad to assure a range of scores on the phenotypic traits to extend the generalizability of the findings, while also being sufficiently narrow to anchor the design and assure the hypotheses are testable. We propose in Aim I to use a univariate proband predictive logistic regression model to evaluate the familial aggregation of BPD with the presence or absence of BPD in a relative as the outcome and "he presence or absence of BPD in the proband associated with that relative as the predictor. In Aim II we will use a univariate proband predictive linear regression model with the level of a given trait in a relative as the outcome and the level of that trait in the proband as the predictor. We will also use structural equation modeling to examine whether coaggregation of traits can conform to standardized models. Finally, we will use this study's sample to develop a gene bank for future exploration of genetic associations with BPD and its phenotypic traits.

描述（由申请人提供）：拟议研究的主要目的是测试边缘性人格障碍（BPD）是否是家族性的（即，概率中的bpd是否与一级亲戚的BPD有关）。拟议研究的第二个目的是测试三个组成的表型人格特征（情感不稳定性，行为障碍和人际不稳定性）本身是否是家族性的。这些特征中的每一个都是BPD以及各种其他精神疾病的潜在相关性格。两种目标都将提供结果，以为我们的分类系统提供信息，并为未来的遗传研究提供潜在客户。拟议的研究将对280个证据和984个一级亲戚进行直接和盲目的评估（每个概率3.5，直接2.7）。这些概率将由100个具有边界人格障碍（BPD），重度抑郁症（MOD）和100个非Borderline比较主题（NBC）（NBC）组成。 MDD和NBC样本将与性别（全女性），年龄和社会种族中的索引BPD概率相匹配。总体抽样策略旨在足够广泛，以确保表型性状上的一系列得分范围扩大发现结果的普遍性，同时也足够狭窄以固定设计并确保假设是可以证实的。我们提出的目的是使用单变量的概率和预测逻辑回归模型来评估BPD的家族聚集，而在相对中存在或不存在BPD作为结果和“他在该相对方面的概率中存在或不存在BPD作为预测器中相关的BPD。在AIM II中，我们将使用该级别的linivarie Promant linivariative linivariate linivariate comptriptive carterive carterive carterive of aft Intiviative of the Univariate over afterive of the Intivive of the Intivive cartive of aft a i级级别的级别，因为该级别的级别是A的级别。在概率中作为预测指标。我们还将使用结构方程建模来检查特质的凝聚是否可以符合标准化模型。最后，我们将使用该研究的样本来开发一个基因库，以将来探索与BPD及其表型特征的遗传关联。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The contribution of familial internalizing and externalizing liability factors to borderline personality disorder.

DOI：
10.1017/s0033291713003140
发表时间：
2014-08
期刊：
PSYCHOLOGICAL MEDICINE
影响因子：
6.9
作者：
Hudson, J. I.;Zanarini, M. C.;Mitchell, K. S.;Choi-Kain, L. W.;Gunderson, J. G.
通讯作者：
Gunderson, J. G.