The Structure of PTSD Comorbidity in the Axis II Domain

轴 II 域中 PTSD 合并症的结构

• 批准号: 7114056
• 负责人: ERIKA J WOLF
• 金额: $ 2.92万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114056
• 关键词: avoidance behavior; behavior prediction; behavioral /social science research tag; clinical research; comorbidity; disease /disorder proneness /risk; human subject; obsessive compulsive disorder; patient oriented research; personality disorders; posttraumatic stress disorder; predoctoral investigator; psychological models; psychological shock; psychopathology; questionnaires; schizoid personality; statistics /biometry

DESCRIPTION (provided by applicant): Research suggests that broad classes of psychopathology are organized along orthogonal dimensions termed internalizing and externalizing. Factor analytic work demonstrates that these temperament-based latent factors account for the expression, severity, and comorbidity in major mental disorders. Recent studies have extended this model into the realm of trauma, providing evidence that these dimensions may similarly account for patterns of comorbidity in posttraumatic stress disorder (PTSD). This work on the structure of PTSD comorbidity is limited to the study of comorbid Axis I disorders and by largely descriptive analyses. Therefore, the goal of the present cross-sectional study is to use multivariate analytic techniques to more fully examine the internalizing and externalizing structure of PTSD comorbidity in the Axis II domain and to investigate the temperament factors that predict the phenotypic expression of this comorbidity in a sample of 250 men and women with PTSD. Doing so will provide support for a parsimonious, dimensional conceptualization of PTSD comorbidity and extend theory on the structure of mental illness into the realms of trauma and Axis II psychopathology.

描述（由申请人提供）：研究表明，沿着所谓的内在化和外部化的正交维度组织了广泛的心理病理学类别。因素分析工作表明，这些基于气质的潜在因素解释了主要精神障碍的表达，严重性和合并症。最近的研究将该模型扩展到了创伤领域，提供了证据表明这些维度可能同样解释了创伤后应激障碍（PTSD）中合并症的模式。有关PTSD合并症结构的这项工作仅限于合并症I疾病的研究和大量描述性分析。因此，本横截面研究的目的是使用多变量分析技术来更充分地检查Axis II领域中PTSD合并症的内在化和外部化结构，并研究预测250名患有PTSD男性和女性样本样本中这种合并症的表型表达的气质因素。这样做将为PTSD合并症的简约，维度概念化提供支持，并将精神疾病结构的理论扩展到创伤和Axis II心理病理学领域。