A Rodent Model of Behavioral Inhibition

行为抑制的啮齿动物模型

基本信息

批准号：
6811476
负责人：
SONIA A CAVIGELLI
金额：
$ 7.25万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-15 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6811476
关键词：
avoidance behavior behavior prediction behavior test behavioral /social science research tag biological models blood tests data collection developmental psychology early experience fear glucocorticoids laboratory rat personality phobias social behavior social conformity socioenvironment stimulus /response

项目摘要

DESCRIPTION (provided by applicant): 'Behavioral inhibition' or 'shyness' among children and adults has been associated with several negative health consequences. Approximately 20% of children are reliably behaviorally inhibited - i.e. they withdraw from novel or unfamiliar circumstances and show greater activation of stress- and fear-associated physiological systems including the hypothalamic-pituitary-adrenal (HPA) axis. The proposed research will test whether a behavioral trait identified as neophobia in the commonly used laboratory rat (Rattus norvegicus) is analogous to the trait identified as behavioral inhibition in humans, such that rats could provide an animal model in which to conduct experimental studies on the causes and consequences of this trait. By developing a non-human model of behavioral inhibition, it becomes possible to conduct life span developmental and experimental studies to determine the environmental and genetic origins of the trait, and to determine potential remedial interventions if the trait is found to be primarily disadvantageous to health. This research will be conducted with Sprague-Dawley rats, a strain of rat in which naturally-occurring variance exists in individual willingness to explore a novel environment and for which stress hormones (glucocorticoids) released by adrenal cortex are related to this trait. The research will assess the stability of this behavioral trait by measuring individual rats' behavioral responses across different conditions and across time, and will measure the dynamics of glucocorticoid production to determine if inhibited individuals experience longer, more chronic, elevations in glucocorticoids, thus making them more prone to health problems. Finally, given the importance of early peer social interactions on personality formation, the research will use an experimental study to determine how peri-pubertal social interactions affect the development of neophobia. This research will provide the basis for future research on the development and long-term consequences of behavioral inhibition / shyness.

描述（由申请人提供）：儿童和成人中的“行为抑制”或“害羞”与几种负面的健康后果有关。大约有20％的儿童在行为上可靠地抑制 - 即他们退出新颖或陌生的情况，并显示出应激和恐惧相关的生理系统的更大激活，包括下丘脑垂体 - 肾上腺肾上腺（HPA）轴。拟议的研究将测试在常用实验室大鼠（Rattus norvegicus）中鉴定为新恐惧症的行为性状是否类似于人类中被确定为行为抑制的性状，以便大鼠可以为动物模型提供有关该性状和后果的实验性研究。通过开发非人类行为抑制模型，可以进行寿命的发育和实验研究以确定特征的环境和遗传起源，并确定如果发现特征主要对健康不利，则可以确定潜在的补救干预措施。这项研究将与Sprague-Dawley大鼠进行，这是一种大鼠的菌株，其中个人愿意探索一种新的环境，并且肾上腺皮质释放的应激激素（糖皮质激素）与这种特征有关。该研究将通过测量各个条件和整个时间的各个大鼠的行为反应来评估这种行为特征的稳定性，并将测量糖皮质激素产生的动力学，以确定抑制的个体是否经历了更长的糖皮质激素升高，从而使它们更容易患健康问题。最后，鉴于早期同伴社会互动对人格形成的重要性，该研究将使用实验研究来确定青春期社会互动如何影响新恐惧症的发展。这项研究将为未来研究行为抑制 /害羞的发展和长期后果的研究提供基础。