Cocaine, Reward Comparison, and Individual Differences

可卡因、奖励比较和个体差异

• 批准号: 6711034
• 负责人: PEARL L SCHROY
• 金额: $ 2.6万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-04 至 2005-03-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6711034
• 关键词: avoidance behavior; behavior prediction; behavioral /social science research tag; chordate locomotion; cocaine; corticosteroid receptors; corticosterone; corticotropin releasing factor; hippocampus; hormone regulation /control mechanism; hypothalamic pituitary adrenal axis; laboratory rat; neuropharmacology; psychopharmacology; receptor binding; reinforcer; self medication; sweetening agents

Previous research has indicated that increased activity of the Hypothalamic-Pituitary-Adrenal (HPA) axis enhances the propensity to self-administer drugs of abuse. We have shown that rats with a greater propensity to self-administer drugs of abuse also avoid intake of a natural gustatory reward after it is repeatedly paired with the opportunity to self-administer the drug reward. Under our reward comparison hypothesis, this avoidance behavior is caused by devaluation of the natural reward in anticipation of the availability of the more rewarding drug of abuse. Thus, we hypothesize that individual differences in activity of the HPA axis mediated individual differences in reward comparison behavior. The proposed studies will test this hypothesis by further investigating these differences in reward comparison behavior. The proposed studies will test this hypothesis by further investigating these differences using a behavioral and physiological approach (Specific Aim I) and by employing pharmacological manipulations to assess the role of corticosterone and corticotropin releasing factor in mediating these individual differences (Specific Aim II).

先前的研究表明，下丘脑 - 垂体 - 肾上腺（HPA）轴的活性增加，增强了自我管理滥用药物的倾向。我们已经表明，在自我管理滥用药物的倾向更大的倾向也避免了自然的阵阵奖励之后，它与有机会自我管理药物奖励后，还避免了自然的阵阵奖励。 在我们的奖励比较假设下，这种回避行为是由于预期更有意义的滥用药物而自然奖励贬值引起的。因此，我们假设HPA轴活动的个体差异介导了奖励比较行为的个体差异。拟议的研究将通过进一步研究奖励比较行为中的这些差异来检验这一假设。拟议的研究将通过使用行为和生理方法进一步研究这些差异来检验这一假设（特定目的I），并采用药理学操纵来评估皮质酮和皮质激素释放因子在介导这些个体差异中的作用（特定目标II）。