An adoption study of the development of early substance use: the joint roles of genetic influences, prenatal risk, rearing environment, and pubertal maturation

早期物质使用发展的收养研究：遗传影响、产前风险、抚养环境和青春期成熟的共同作用

• 批准号: 10542479
• 负责人: Jenae M. Neiderhiser
• 金额: $ 5.99万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542479
• 关键词: Accounting; Address; Adolescence; Adolescent Development; Adoption; Adrenal Glands; Age; Area; Attention; Behavior; Behavioral; Biological; Birth; Cessation of life; Child; Child Behavior; Crime; Data; Development; Developmental Course; Disease; Environment; Environmental Risk Factor; Event; Executive Dysfunction; Family; Genes; Genetic; Growth and Development function; Hair; Health; Height; Heritability; Hormonal; Hormonal Change; Hormones; Hypothalamic structure; Individual; Injury; Investigation; Joints; Knowledge; Life; Link; Literature; Longitudinal Studies; Mediating; Mental Health; Parents; Pathway interactions; Pharmaceutical Preparations; Pituitary Gland; Positioning Attribute; Prevention; Productivity; Puberty; Research; Risk; Risk Behaviors; Role; Sampling; Sampling Studies; Screening procedure; Sex Characteristics; Specificity; Substance Use Disorder; Symptoms; Testing; Time; Triad Acrylic Resin; Work; Youth; addiction; adolescent substance use; adopted child; alcohol use initiation; behavioral outcome; biobehavior; cohort; comorbidity; design; drug use in pregnancy; early adolescence; early satiety; economic cost; externalizing behavior; high risk; improved; indexing; infancy; innovation; middle childhood; peer; postnatal; prenatal; prenatal exposure; prenatal health; prenatal influence; professional atmosphere; prospective; recruit; screening; sex; substance use; transmission process; uptake

Project Summary/Abstract The proposed research will clarify how heritable risks and prenatal and postnatal environments work together with hormonal changes to influence the development of risk for early substance use (SU) and related problems in adolescence. Understanding the development of SU problems is a vital health concern due to the economic costs of dealing with SU related injury, illness, death, crime, and lost productivity. Pathways and interactions by which genes, prenatal exposures, hormones, and key postnatal environmental factors influence the development of SU are not fully understood, in part because studies have not considered them together. The proposed research is innovative by using and expanding an existing prospective longitudinal adoption study, the Early Growth and Development Study (EGDS) to address the dearth of research combining heritable, prenatal, hormone, and postnatal influences. This proposal is timely, directly addressing PA-15-110, by using genetically informative approaches to expand research on the interplay of genetic and environmental factors in the genesis and course … of substance use disorders and comorbid conditions. The EGDS is a longitudinal study of children adopted at birth and their birth and adoptive parents (N = 561 linked triads). We propose to collect new data into early adolescence on SU milestones and related behaviors, and pubertal development. We will use existing and new data to: (SA1) estimate the unique contributions of heritable risk, prenatal, and postnatal environmental influences on trajectories of child behaviors from infancy to adolescence that increase risk for SU; (SA2) examine the mediating role of prenatal exposures for transmitting heritable influences on trajectories of behavioral risk for SU; (SA3) examine the mediating role of hormone development for transmitting heritable, prenatal and postnatal environmental influences on trajectories of behavioral risk for SU; and (SA4) Examine moderation of heritable, prenatal, and hormone influences by postnatal environments to elucidate the possible interactions among these factors in influencing child risk behaviors and early SU. This study will help to advance knowledge of the development of adolescent SU, to clarify which children are at greater risk for developing SU early in adolescence, and which influences are most salient for SU development given multiple other influences. This prospective, longitudinal, genetically-informed investigation using the EGDS is uniquely poised to achieve these aims, which are critical for gaining a more precise understanding of factors influencing the developmental course of SU that can be used to improve prevention efforts.

项目概要/摘要 拟议的研究将阐明遗传风险与产前和产后环境如何 与荷尔蒙变化一起影响早期物质风险的发展 青春期的使用（SU）和相关问题了解SU问题的发展。 由于处理 SU 相关伤害、疾病、 死亡、犯罪和生产力丧失的基因、产前的途径和相互作用。 暴露、激素和关键的产后环境因素影响发育 SU 尚未被完全理解，部分原因是研究没有将它们放在一起考虑。 拟议的研究通过使用和扩展而具有创新性 现有的预期纵向 收养研究，早期生长和发育研究（EGDS）来解决 缺乏 结合遗传、产前、激素和产后影响的研究。 及时、直接解决 PA-15-110，通过使用遗传信息方法来扩展 研究遗传和环境因素在发生和过程中的相互作用…… EGDS 是一项针对儿童的纵向研究。 出生时被收养的人及其出生和养父母（N = 561 个关联三合会）。 收集青春期早期有关 SU 里程碑和相关行为以及青春期的新数据 我们将使用现有的和新的数据来：（SA1）估计的独特贡献。 遗传风险、产前和产后环境对儿童行为轨迹的影响 从婴儿期到青春期，SU 风险增加；（SA2）检查中介作用 产前暴露可传播对 SU 行为风险轨迹的遗传影响； (SA3) 检查激素发育对于传递遗传性、产前性的中介作用 和产后环境对 SU 行为风险轨迹的影响； 检查产后环境对遗传、产前和激素影响的调节 阐明这些因素在影响儿童危险行为方面可能存在的相互作用， 早期 SU 的研究将有助于增进对青少年 SU 发展的了解， 明确哪些儿童在青春期早期发生 SU 的风险更大，以及哪些儿童 考虑到多种其他影响，这些影响对于 SU 的发展最为显着。 使用 EGDS 进行前瞻性、纵向、遗传信息调查具有独特的优势 实现这些目标对于更准确地了解因素至关重要 影响 SU 的发展过程，可用于改善预防工作。

项目成果

Does Maternal Warmth Moderate Longitudinal Associations Between Infant Attention Control and Children's Inhibitory Control?

母亲的温暖是否调节婴儿注意力控制和儿童抑制控制之间的纵向关联？

• 发表时间: 2020
• 影响因子: 2.2
• 作者: Cioffi, Camille C;Leve, Leslie D;Natsuaki, Misaki N;Shaw, Daniel S;Reiss, David;Neiderhiser, Jenae M
• 通讯作者: Neiderhiser, Jenae M

Impact of hair type, hair sample weight, external hair exposures, and race on cumulative hair cortisol.

头发类型、头发样本重量、头发外部暴露和种族对累积头发皮质醇的影响。

• 发表时间: 2022-08
• 影响因子: 3.7
• 作者: Moody, Shannin N;van Dammen, Lotte;Wang, Wen;Greder, Kimberly A;Neiderhiser, Jenae M;Afulani, Patience A;Willette, Auriel;Shirtcliff, Elizabeth A
• 通讯作者: Shirtcliff, Elizabeth A

Child Effects on Parental Negativity: The Role of Heritable and Prenatal Factors.

儿童对父母消极情绪的影响：遗传和产前因素的作用。

• 发表时间: 2020
• 影响因子: 4.6
• 作者: Liu, Chang;Ji, Linying;Chow, Sy;Kang, Boyoung;Leve, Leslie D;Shaw, Daniel S;Ganiban, Jody M;Natsuaki, Misaki N;Reiss, David;Neiderhiser, Jenae M
• 通讯作者: Neiderhiser, Jenae M

Do I Look Gawky? The Association between Pubertal Asynchrony and Peer Victimization.

我看起来笨拙吗？

• 发表时间: 2021-09-10
• 作者: Natsuaki, Misaki N;Stepanyan, Sofia T;Neiderhiser, Jenae M;Shaw, Daniel S;Ganiban, Jody M;Reiss, David;Leve, Leslie D
• 通讯作者: Leve, Leslie D

Parenting in the Context of the Child: Genetic and Social Processes.

儿童背景下的育儿：遗传和社会过程。

• 发表时间: 2022-03
• 影响因子: 9.5
• 作者: Reiss, David;Ganiban, Jody M;Leve, Leslie D;Neiderhiser, Jenae M;Shaw, Daniel S;Natsuaki, Misaki N
• 通讯作者: Natsuaki, Misaki N