HABS-HD - Core A - Admin Core

HABS-HD - 核心 A - 管理核心

• 批准号: 10493845
• 负责人: Sid E O'Bryant
• 金额: $ 115.51万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493845
• 关键词: Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Biological Markers; Biometry; Biostatistics Core; Clinic; Clinical; Collaborations; Collection; Communication; Communities; Complement; Data; Data Collection; Decision Making; Development; Effectiveness; Ensure; Ethnic group; Goals; Health; Health Disparities Research; Informatics; Institution; Institutional Review Boards; Leadership; Literature; Methods; Mission; Monitor; Not Hispanic or Latino; Participant; Patient Recruitments; Pharmaceutical Preparations; Policies; Population Heterogeneity; Positron-Emission Tomography; Principal Investigator; Procedures; Protocols documentation; Publications; Quality Control; Recommendation; Reporting; Research; Research Personnel; Resources; Science; Series; Structure; System; Time; Tracer; Work; aging brain; base; data access; data dissemination; data portal; data quality; health disparity; health goals; interest; meetings; neuroimaging; organizational structure; outreach; programs; racial and ethnic; tau Proteins

HABS-HD ADMINISTRATIVE CORE (CORE A) - ABSTRACT Core A has been providing leadership and management to the Health & Aging Brain Study – Health Disparities (HABS-HD) study since inception and has ensured all proposed metrics have been met. Core A will continue to support the overall mission of HABS-HD to achieve the long-term goal of establishing a comprehensive understanding of AT(N) defined biomarkers across diverse populations, thereby addressing one of the most critical gaps in the existing literature as well as multiple components of NIA AD+ADRD Research Implementation Milestone 1. Given the recent approval of an anti-amyloid drug, this work is now more important than ever. The overall goal of the HABS-HD Core A is to continue to provide critical organizational oversight in order to accomplish the scientific goals and to serve as the nexus of leadership for the U19 as a whole and each of its interlocking Cores, Projects, and committees. Core A will coordinate the integrated components and activities of HABS-HD to accomplish the following aims: Aim 1: Provide organizational support and structure to the Multi Principal Investigator (MPI) team, Cores, Projects and committees. Aim 2: Continue to provide structured communication activities for the HABS-HD team. Organize and make decisions on recommendations from the Core and Project Leads and committees as well as execute those decisions. Organize and plan the annual HABS-HD meetings. Organize and be responsible for any/all NIA communications and reporting. Aim 3: Work with the Cores, Projects, Executive Committee (EC) and Steering Committee (SC) to: (a) continue to refine and monitor structure for ensuring progress towards goals for all aspects of HABS-HD including participant recruitment/retention, protocol refinement and development, participant assessments, biospecimen collection, storage and dissemination of data and biospecimens, (b) ensure timely completion of the HABS-HD Projects and (c) monitor all IRB and FDA IND (PET tau tracer) aspects of the study. Aim 4: Working with all Cores, ensure the refinement/development and public availability of all HABS-HD policies and procedures for data collection, data quality control (QC), resource (data and biospecimens) sharing and dissemination, publications, and potential new research directions. Aim 5: Work with the Neuroimaging & Informatics Core, Biostatistics Core and data teams, to generate, refine and implement a series of policies and committees to support access to data through the LONI data portal. Promote and encourage utilization of these unique and valuable data. Monitor data utilization and ensure that systems for data access are effective and efficient. Work with the Development Core to ensure access of HABS-HD data to junior investigators interested in health disparities research in AD. Aim 6: Work with all Core and Project Leads/Co-Leads to ensure maximum collaboration within the HABS-HD team. Aim 7: Work with all Cores to ensure maximum overlap with other ongoing, large-scale AD+ADRD programs to ensure cross-study comparisons and facilitate access to HABS-HD data for these other initiatives.

HABS-HD 管理核心（核心 A）- 摘要 核心 A 一直为健康与老龄化大脑研究 - 健康差异提供领导和管理 (HABS-HD) 研究自启动以来已确保所有拟议指标均已得到满足，核心 A 将继续得到满足。 支持 HABS-HD 的总体使命，实现建立全面的长期目标 了解不同人群中 AT(N) 定义的生物标志物，从而解决最重要的问题之一 现有文献以及 NIA AD+ADRD 研究的多个组成部分中的关键差距 实施里程碑 1. 鉴于最近批准了一种抗淀粉样蛋白药物，这项工作现在更加重要 HABS-HD 核心 A 的总体目标是继续提供关键的组织能力。 监督，以实现科学目标并作为 U19 的领导纽带 整体及其每个相互关联的核心、项目和委员会将协调整合的核心 A。 HABS-HD 的组成部分和活动旨在实现以下目标： 目标 1：提供组织 对多首席研究员 (MPI) 团队、核心、项目和委员会的支持和结构 目标 2： 继续为 HABS-HD 团队提供结构化沟通活动的组织和决策。 根据核心和项目负责人和委员会的建议并执行这些决定。 组织和策划年度 HABS-HD 会议 组织并负责任何/所有 NIA。 目标 3：与核心、项目、执行委员会 (EC) 和指导部门合作。 委员会 (SC) 将： (a) 继续完善和监督结构，以确保在实现所有人的目标方面取得进展 HABS-HD 的各个方面，包括参与者招募/保留、方案完善和开发， 评估、生物样本参与者收集、存储和传播数据和生物样本，(b) 确保及时完成 HABS-HD 项目并 (c) 监控所有 IRB 和 FDA IND（PET tau 示踪剂） 目标 4：与所有核心合作，确保完善/开发和公共可用性 所有 HABS-HD 数据收集、数据质量控制 (QC)、资源（数据和 生物样本）共享和传播、出版物和潜在的新研究方向。 与神经影像和信息学核心、生物统计学核心和数据团队合作，生成、完善和 实施一系列政策和委员会，以支持通过 LONI 数据门户访问数据。 促进和鼓励利用这些独特且有价值的数据。监控数据的利用并确保： 与开发核心合作以确保数据访问系统有效且高效。 向对 AD 健康差异研究感兴趣的初级研究人员提供 HABS-HD 数据目标 6：与所有核心人员合作。 目标 7：与所有人合作。 确保与其他正在进行的大规模 AD+ADRD 项目最大程度重叠的核心，以确保交叉研究 比较并促进获取这些其他举措的 HABS-HD 数据。