MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

少数民族高中生研究学徒计划

• 批准号: 2282333
• 负责人: ELIZABETH F ABBOTT
• 金额: $ 1.3万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-03-01 至 1995-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2282333
• 关键词: minority institution research support; secondary schools

This proposal seeks funds for the acquisition of a 64-bit array processor to be used in conjunction with an existing 32-bit minicomputer. Projects in four subject areas will benefit from access to such a high speed computational capability. The four projects are: 1) a simulation of the urinary concentrating mechanism in the renal medulla. Previous simulations have fallen short of predicting the performance achieved by laboratory animals; this project seeks to improve performance by incorporating known membrane transport parameters into a more realistic model of medullary anatomy. The simulation will require the solution of a large non-linear boundary value problem. 2a) a syntactic model of glycogen metabolism in liver and muscle. Compartment models based on radioactive tracer data have failed to deal with recycling of tracer molecules, and also with the difficulty of predicting the incorporation of tracer into glycogen, a large polysaccharide molecule with a preferred order of glucose incorporation and removal. Syntactic modelling keeps track of each carbon atom in each molecule as it progresses through the metabolic pathways. 2b) A minimal model of body glucose and insulin dynamics has been used in human beings to aid in the early diagnosis of diabetes mellitus; the method depends on measuring the response to a standard forcing by injecting glucose. The success of the approach now requires the design of optimal strategies for both injection and sampling protocols. 3) The Na-K-ATPase is an ubiquitous transport enzyme which has come to occupy a central place in most schemes of cellular electrolyte transport and cell volume regulation. Complete amino acid sequence information is available for this protein, but understanding the mechanism of transport and of energy transduction requires the determination of secondary and tertiary protein structure. An attempt will be made to simulate these structures from the known sequences. 4) Experimental evidence suggests that the semicircular canal cupula of the vestibular apparatus in the guitarfish acts as a pressure sensitive membrane with site specific response characteristics related to the dynamics of the stimulus. This hypothesis can be evaluated by a finite element analysis that includes temporally as well as spatially dependent variables.

该提案为收购64位阵列寻求资金 与现有的32位结合使用的处理器 微型计算机。 四个主题领域的项目将从 访问如此高速计算能力。 四个 项目是：1）尿液集中的模拟 肾脏髓质的机制。 以前的模拟有 缺乏预测通过 实验动物；该项目旨在通过 将已知的膜传输参数纳入更多 髓质解剖的现实模型。 模拟将 需要解决大型非线性边界值的解决方案 问题。 2a）肝脏中糖原代谢的句法模型 和肌肉。 基于放射性示踪剂的隔室模型 数据未能处理示踪剂分子的回收，并且 而且很难预测示踪剂的掺入 进入糖原，一个具有首选的大多糖分子 葡萄糖掺入和去除的顺序。 句法建模 跟踪每个分子中的每个碳原子 通过代谢途径进行。 2b）最小 身体葡萄糖和胰岛素动力学的模型已用于 人类有助于早期诊断糖尿病； 该方法取决于测量对标准的响应 通过注射葡萄糖强迫。 现在方法的成功 需要设计注射和最佳策略 采样协议。 3）NA-K-ATPase无处不在 运输酶已占据中心位置 细胞电解质传输和细胞体积的大多数方案 规定。 完整的氨基酸序列信息是 可用于该蛋白质，但了解 运输和能量转导需要确定 二级和三级蛋白质结构。 尝试 从已知序列中模拟这些结构。 4） 实验证据表明半圆形管 吉他鱼中的前庭设备的库库充当 压力敏感膜具有特定位点响应 与刺激动力学有关的特征。 这 可以通过有限元分析来评估假设 包括时间和空间依赖性变量。