TRAJECTORY SPECIFICATION IN TARGETED LIMB MOVEMENT

目标肢体运动的轨迹规范

• 批准号: 2264609
• 负责人: CLAUDE P GHEZ
• 金额: $ 18.67万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2264609
• 关键词: afferent nerve; biomechanics; brain disorder diagnosis; cerebellar disorders; electromyography; human subject; limb movement; nervous system disorder; neural information processing; neuromuscular transmission; physical model; proprioception /kinesthesia; psychomotor function; psychomotor reaction time; psychomotor tracking; sensorimotor system; sensory disorders; sensory feedback; short term memory; stimulus /response; visual feedback; young adult human (21-34)

The proposed studies aim to identify and analyze the sensorimotor transformations by which the central nervous system achieves accurate control of multijoint movements directed at visual targets. They address the specific question of how information about the location and state of the limb and about the target operate to assure the accurate programming and control of movement. Experiments are to be done with normal subjects, with patients affected by severe large-fiber neuropathy and with patients with circumscribed cerebellar lesions. A novel procedure, the timed response paradigm, will be used to analyze the time course and nature of the processes by which the direction and extent of movement are specified. It is hypothesized that a fundamental cause of the inaccuracy of both sensory neuropathy and cerebellar dysmetria is a failure to take state-dependent and dynamic interactions into account in both the programming and control of multijoint movement. This hypothesis is based on preliminary results which indicate that distinctive errors in direction and extent are attributable to simplifications in the kinematic and dynamic transformations by which target location is eventually converted into the muscle commands needed to bring the hand to the target. These systematic programming errors are greatly magnified in patterns deprived of proprioceptive sensation but can be partially corrected by vision of the limb prior to movement. This effect is, however, transitory and its time course will be determined. The proposed studies will also determine the mechanisms of the impairment in interjoint coordination shown in preliminary work to follow the loss of proprioceptive sensation. In its latter phase, the proposed work will characterize the movement errors made by patients with medial and lateral lesions of the cerebellar hemispheres. The role of these structures in short-term learning may allow them to participate in the generation and continual refinement of internal models of the limb.

拟议的研究旨在识别和分析感觉运动 中枢神经系统实现准确的转换 控制针对视觉目标的多关点运动。 他们 解决有关位置信息的特定问题和 肢体和目标的状态可起步，以确保准确 编程和移动的控制。 实验要完成 正常受试者，患者受到严重的大纤维神经病的影响 并患有限制小脑病变的患者。 小说 程序，定时响应范式将用于分析时间 过程的过程和性质 指定运动。 假设是 感觉神经病和小脑Dysmetria的不准确性是 未能考虑到国家依赖和动态互动 多关运动的编程和控制。 这 假设基于初步结果，表明 方向和程度上的独特错误归因于 运动和动态转换中的简化 目标位置最终被转换为所需的肌肉命令 将手带到目标。 这些系统的编程错误 被剥夺了本体感受的模式大大放大 但是可以在运动之前通过对肢体的视力进行部分纠正。 但是，这种效果是短暂的，其时间课程将是 决定。 拟议的研究还将确定 初步工作中所示的间协调障碍 遵循本体感受的丧失。 在后期， 拟议的工作将表征患者的运动错误 小脑半球的内侧和外侧病变。 角色 在短期学习中的这些结构中，可能使他们能够参与 在一代和不断的改进中 肢。