TRAJECTORY SPECIFICATION IN TARGETED LIMB MOVEMENT

目标肢体运动的轨迹规范

• 批准号: 3405533
• 负责人: CLAUDE P GHEZ
• 金额: $ 14.63万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3405533
• 关键词: auditory feedback; biomechanics; body movement; brain disorder diagnosis; cerebellar disorders; cues; electromyography; human subject; limb movement; muscle contraction; muscle tension; neural information processing; neuromuscular transmission; proprioception /kinesthesia; psychomotor function; psychomotor reaction time; psychomotor tracking; sensorimotor system; sensory disorders; sensory feedback; stimulus /response

Our long term objectives are to gain further understanding of the neural processes that enable us to move our limbs rapidly and accurately to targets around us and to explain the disordered accuracy of patients with sensory impairment and cerebellar dysmetria. We also hope to devise effective methods for improving motor performance in such patients. Our approach is to analyze in detail the performance of a simple motor task to uncover fundamental principles by which the nervous system controls the musculoskeletal system. The present proposal extends work accomplished in the current period that was focused exclusively on the production of simple isometric responses. First, we plan to determine how the amplitude and direction of an aimed response are specified using information derived from a target. The problem is addressed using a new experimental procedure by which the time interval from stimulus to response can be varied systematically. Second, we plan to determine the differences in control strategies used for the producing force and position trajectories when subjects are faced with different loading conditions. Particular attention is given to the problem of decelerating inertial loads using accurately timed commands to antagonists. Third, we plan to analyze the disorders in trajectory formation of patients with severe sensory neuropathies. Preliminary observations in two patients indicate that inaccurate performance results from impairment in the ability to program trajectory parameters as well as from an inability to make effective use of internal feedback mechanisms to correct initial trajectory errors. Proposed experiments will use auditory cues to substitute for the lost proprioceptive information in order to improve accuracy and updating. Fourth, we will initiate a study of cerebellar dysmetria to determine the mechanisms responsible for the inaccuracy and the delays in movement initiation shown by such patients.

我们的长期目标是进一步了解 使我们能够快速移动四肢的神经过程 准确地指向我们周围的目标并解释失调 感觉障碍和小脑患者的准确性 甲状腺肿。 我们还希望设计有效的改进方法 此类患者的运动性能。 我们的方法是分析 详细说明简单的电机任务的性能 神经系统控制的基本原理 肌肉骨骼系统。 目前的建议扩展了工作 在当前时期仅专注于 简单的等距响应的产生。 首先，我们计划 确定瞄准响应的幅度和方向是如何 使用从目标得出的信息指定。 问题是 使用新的实验过程解决 从刺激到响应的间隔可以系统地变化。 其次，我们计划确定控制策略的差异 用于生产力和位置轨迹时 受试者面临着不同的加载条件。 特别的 注意减速惯性负荷的问题 使用准确的定时命令与对手。 第三，我们计划 分析患者的轨迹形成障碍 严重的感觉神经病。 两次的初步观察 患者表明表现不正确 编程轨迹参数的功能的损害 由于无法有效利用内部反馈 纠正初始轨迹错误的机制。 建议的 实验将使用听觉提示代替丢失 本体感受信息，以提高准确性和 更新。 第四，我们将启动小脑肌中的研究 确定导致不准确性和的机制 此类患者显示的运动启动延迟。