SimulScan: Simultaneous functional and dynamic MRI for evaluating swallowing across age and in neurogenic dysphagia

SimulScan：同步功能和动态 MRI，用于评估跨年龄吞咽和神经源性吞咽困难

• 批准号: 10660667
• 负责人: Georgia Malandraki
• 金额: $ 54.39万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660667
• 关键词: Adult; Affect; Age; Agreement; Anatomy; Biomechanics; Brain; Brain Mapping; Brain imaging; Clinical; Clinical Management; Coupled; Data; Deglutition; Deglutition Disorders; Dehydration; Development; Diagnosis; Diagnostic; Disease; Elderly; Endoscopy; Etiology; Event; Foundations; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Health; Hospitalization; Image; Imaging Device; Imaging Techniques; Least-Squares Analysis; Life; Link; Magnetic Resonance Imaging; Malnutrition; Maps; Measurement; Measures; Mental Depression; Methods; Modality; Motion; Multimodal Imaging; Nature; Neurologic; Oropharyngeal; Outcome; Parkinson Disease; Pathway interactions; Patients; Peripheral; Phenotype; Physiological; Physiology; Population; Prognosis; Protocols documentation; Quality of life; Rehabilitation therapy; Research; Respiratory Tract Infections; Roentgen Rays; Sampling; Severities; Signal Transduction; Stroke; Task Performances; Techniques; Technology; Therapeutic Intervention; Three-Dimensional Imaging; Time; Treatment outcome; Visualization; age group; age related; aged; common symptom; diagnostic accuracy; falls; human very old age (85+); imaging approach; imaging modality; improved; improved outcome; individual patient; insight; mortality; multimodality; nervous system disorder; neural; neuromechanism; neurophysiology; neurotransmission; novel; novel strategies; personalized therapeutic; profiles in patients; research and development; respiratory; targeted treatment; technology development; temporal measurement; three-dimensional visualization; tool; young adult; Adult; Affect; Age; Agreement; Anatomy; Biomechanics; Brain; Brain Mapping; Brain imaging; Clinical; Clinical Management; Coupled; Data; Deglutition; Deglutition Disorders; Dehydration; Development; Diagnosis; Diagnostic; Disease; Elderly; Endoscopy; Etiology; Event; Foundations; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Health; Hospitalization; Image; Imaging Device; Imaging Techniques; Least-Squares Analysis; Life; Link; Magnetic Resonance Imaging; Malnutrition; Maps; Measurement; Measures; Mental Depression; Methods; Modality; Motion; Multimodal Imaging; Nature; Neurologic; Oropharyngeal; Outcome; Parkinson Disease; Pathway interactions; Patients; Peripheral; Phenotype; Physiological; Physiology; Population; Prognosis; Protocols documentation; Quality of life; Rehabilitation therapy; Research; Respiratory Tract Infections; Roentgen Rays; Sampling; Severities; Signal Transduction; Stroke; Task Performances; Techniques; Technology; Therapeutic Intervention; Three-Dimensional Imaging; Time; Treatment outcome; Visualization; age group; age related; aged; common symptom; diagnostic accuracy; falls; human very old age (85+); imaging approach; imaging modality; improved; improved outcome; individual patient; insight; mortality; multimodality; nervous system disorder; neural; neuromechanism; neurophysiology; neurotransmission; novel; novel strategies; personalized therapeutic; profiles in patients; research and development; respiratory; targeted treatment; technology development; temporal measurement; three-dimensional visualization; tool; young adult

PROJECT SUMMARY Dysphagia, or difficulty swallowing, affects over 9 million adults in the US annually, with neurologic conditions, such as stroke and Parkinson’s disease (PD), being the number one cause of the disorder. Dysphagia in neurologic disease is associated with significant negative outcomes, such as prolonged hospitalization, respiratory compromise, depression, malnutrition, and mortality. A better understanding of both the central (neural) and physiological/biomechanical deficits seen in neurogenic dysphagia will enable better clinical management through improved identification of patients and the development of targeted and personalized therapeutic interventions. No current tools exist to enable the concurrent 3D visualization of swallowing physiological/biomechanical events along with the associated functional brain activity that drives those events. This project will optimize and validate a novel multimodal imaging method and analysis platform to visualize and quantify both swallowing physiology events and brain function during swallowing using magnetic resonance imaging. Using a recently-developed framework for fast dynamic imaging, a technique will be demonstrated and validated that will achieve full 3D imaging of the functional swallowing anatomy along with imaging of brain function, simultaneously. The resulting method will provide unprecedented high-spatial and high-temporal resolution images of the dynamic swallowing motions and the brain activity associated with this critical life-sustaining function and has the potential to offer a new state-of-the-art diagnostic and treatment outcome tool for neurogenic dysphagia. Utilizing the new multimodal imaging method, we will demonstrate the sensitivity to changes in swallowing function and neural activity by examining a group of young (aged 18-25 years old) and older (aged 60-85 years old) healthy adults performing incidental swallows and other oropharyngeal tasks. We will then establish the preliminary sensitivity of this new approach in identifying phenotypes of neurogenic dysphagia in patients with stroke and Parkinson’s disease (n=60 for each condition). The technique will enable the determination of differential dynamic motion and fMRI signatures of dysfunction within and across conditions/diseases. This line of research will have an important positive impact because it has the potential to improve neurogenic dysphagia characterization and to provide the foundation to start improving diagnostic accuracy, prognosis, and treatment of this debilitating condition in the future.

项目摘要 吞咽困难或困难的吞咽，每年都会影响美国超过900万成年人，神经系统 疾病，例如中风和帕金森氏病（PD），是该疾病的第一名。 神经系统疾病中的吞咽困难与显着的负面结果相关，例如长期 住院，呼吸折衷，抑郁，营养不良和死亡率。更好地理解 神经源性吞咽困难中的中心（神经）和物理/生物力学缺陷都将启用 通过改善患者的识别和目标发展，更好地临床管理 和个性化的治疗干预措施。没有目前的工具来启用并发3D可视化 吞咽物理/生物力学事件以及相关的功能性脑活动 推动这些事件。该项目将优化和验证一种新型的多模式成像方法，并且 分析平台可视化和量化吞咽生理事件和大脑​​功能 使用磁共振成像吞咽。使用最近开发的框架进行快速动态 成像，将证明和验证该技术，以实现功能的完整3D成像 简单地吞咽解剖学以及大脑功能的成像。最终的方法将提供 动态吞咽运动和 与这种维持生命的功能相关的大脑活动，并有可能提供新的 神经源性吞咽困难的最新诊断和治疗结果工具。利用新的 多模式成像方法，我们将证明对吞咽功能变化的敏感性和 神经活动通过检查一组年轻（18-25岁）及以上（60-85岁） 健康的成年人执行偶然的燕子和其他口咽任务。然后，我们将建立 这种新方法在识别患者神经源性吞咽表型方面的初步敏感性 患有中风和帕金森氏病（每种疾病n = 60）。该技术将实现决心 跨条件/疾病内外功能障碍的差异动态运动和fMRI特征。 这一研究将产生重要的积极影响，因为它有可能改善 神经源性吞咽困难并为开始改善诊断的基础 未来这种使人衰弱状况的准确性，预后和治疗。