Pubertal, Psychological and Physiological Development in Females with Autism

自闭症女性的青春期、心理和生理发育

基本信息

批准号：
10460717
负责人：
Blythe Anne Corbett
金额：
$ 73.43万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10460717
关键词：
10 year old Address Adolescent Advanced Development Age Age of Onset Anxiety Area Arousal Behavior Biological Body mass index Breast Complex Cross-Sectional Studies Data Development Economics Education Electroencephalography Endocrine Enrollment Entire hair of pubis Environmental Risk Factor Estradiol Ethnic Origin Female Female Adolescents Genetic Goals Gold Growth Height Hormones Human Hydrocortisone Impairment Intervention Link Luteinizing Hormone Menstrual cycle Menstruation Mental Depression Mental Health Neuraxis Outcome Peripheral Nervous System Physiological Plasma Population Psychological Impact Puberty Race Reporting Research Risk Same-sex Sampling Series Services Social Functioning Social Interaction Staging Stress Symptoms Time Withdrawal adolescent with autism spectrum disorder autism spectrum disorder base biobehavior biological adaptation to stress biopsychosocial cohort depressive symptoms girls hypothalamic-pituitary-adrenal axis improved longitudinal design male multimodality peer peer victimization physical conditioning psychologic psychosocial pubertal timing rate of change relating to nervous system research and development response service intervention sex skills social social communication social skills

项目摘要

Project Summary/Abstract Puberty is among the most complex developmental transitions over the human lifetime. The timing (age of onset) and tempo (rate of change) of puberty can significantly and negatively impact physical, psychosocial and physiological functioning, especially in females. Autism spectrum disorder (ASD) is characterized by impaired reciprocal social communication and poor adaptation to change; thus, the onset and course of puberty marks a pivotal transition. In a series of cross-sectional studies, findings from the study team have shown: 1) advanced pubertal timing for female youth with ASD compared to typically developing females (i.e., breast development, menses) using rigorous assessment of pubertal staging; 2) distinct camouflaging behaviors in females with ASD when socially interacting with peers; 3) higher depressive symptoms in early adolescents with ASD, especially females; 4) sex-based differences in neural socioemotional processing in youth with ASD; and 5) elevated stress and arousal in youth with ASD compared to same-age TD peers that increases with age and pubertal development. Consistent across these studies is the unique profile of females with ASD and the potential deleterious impact of early puberty in this vulnerable, understudied population and developmental window. While the previous and ongoing pubertal development research is compelling, at the start of enrollment, 80% of the 10-year old females with ASD had already entered puberty compared to 29% of the TD group; therefore, the true onset of puberty could not be determined. Moreover, it was based on a relatively small sample of females with ASD 10-13 years (N = 35). Thus, a comprehensive exploration of pubertal maturation in a large sample of younger girls with ASD is needed. The overarching goal is to systematically examine the precise onset, tempo and course of pubertal, psychosocial and physiological development in females with ASD using a multimodal, multimethod, accelerated longitudinal design. A large sample of females with ASD (n=120) and TD (n=120) spanning 6 to 15 years will be followed over four years: Cohort 1 enrolled at 6-years (follow 6-9), Cohort 2 enrolled at 8-years (follow 8-11), Cohort 3 enrolled at 10-years (follow 10-13) and Cohort 4 enrolled at 12-years (follow 12-15). The aims will address three key areas. Aim 1: Pubertal development - will examine the timing, tempo and course of puberty based on physical development (Tanner stage (TS), body mass index (BMI), height, linear growth velocity (LGV)), hormones (Estradiol, Luteinizing Hormone (LH)), and menstrual cycle. Aim 2: Psychosocial profiles - will examine reciprocal social communication (CASS) and internalizing symptoms (anxiety and depression) at the onset and over the course of pubertal development. Aim 3. Physiological characterization - will simultaneously examine social functioning at the level of the central nervous system (EEG hyperscanning), HPA axis (cortisol) and peripheral nervous system (RSA) during naturalistic social interactions between same-sex peers. The findings will reveal the impact of the onset, tempo and course of puberty on females with ASD to improve education, inform services, and develop interventions, which are lacking.

项目概要/摘要青春期是人类一生中最复杂的发育转变之一。发病时间（发病年龄）青春期的节奏（变化率）会对身体、心理和社会产生显着的负面影响。生理功能，尤其是女性。自闭症谱系障碍 (ASD) 的特点是受损相互的社会沟通和对变化的适应能力差；因此，青春期的开始和进程标志着关键的转变。在一系列横断面研究中，研究小组的研究结果表明：1）先进患有自闭症谱系障碍 (ASD) 的女性青少年的青春期时间与典型发育女性（即乳房发育、月经）使用青春期阶段的严格评估； 2）患有自闭症谱系障碍的女性有明显的伪装行为与同伴进行社交互动时； 3）患有自闭症谱系障碍（ASD）的早期青少年的抑郁症状较高，尤其是女性； 4) 患有自闭症谱系障碍 (ASD) 青少年的神经社会情感处理存在性别差异； 5）压力升高与同龄 TD 同龄人相比，患有 ASD 的青少年的性唤起程度随着年龄和青春期的增加而增加发展。这些研究的一致之处在于患有自闭症谱系障碍的女性的独特特征以及潜在的青春期提前对这个脆弱的、未得到充分研究的人群和发育窗口产生了有害影响。尽管之前和正在进行的青春期发育研究非常引人注目，在入学之初，80% 的人患有 ASD 的 10 岁女性已经进入青春期，而 TD 组的这一比例为 29%；因此，无法确定青春期的真正开始时间。此外，它是基于相对较小的女性样本患有 ASD 10-13 岁 (N = 35)。因此，对大样本的青春期成熟进行全面探索需要患有 ASD 的年轻女孩。总体目标是系统地检查精确的开始、节奏使用多模式研究患有自闭症谱系障碍 (ASD) 的女性的青春期、心理社会和生理发育过程，多方法、加速纵向设计。患有 ASD (n=120) 和 TD (n=120) 的女性大样本跨越 6 至 15 年的研究将在四年内进行跟踪：队列 1 在 6 岁时注册（跟随 6-9），队列 2 8 年级入学（遵循 8-11），队列 3 于 10 年级入学（遵循 10-13），队列 4 于 12 年级入学（遵循 12-15）。这些目标将涉及三个关键领域。目标 1：青春期发育 - 将检查时间，基于身体发育的青春期节奏和过程（坦纳阶段（TS）、体重指数（BMI）、身高、线性生长速度（LGV））、激素（雌二醇、黄体生成素（LH））和月经周期。目标 2：心理社会概况 - 将检查相互社会沟通（CASS）和内化症状（焦虑和抑郁）在青春期发育开始时和整个过程中。目标 3. 生理表征 - 将同时检查中枢神经系统水平的社会功能（脑电图自然社交互动期间的超扫描）、HPA 轴（皮质醇）和周围神经系统 (RSA) 同性同性之间。研究结果将揭示青春期的开始、节奏和过程的影响为患有自闭症谱系障碍的女性提供帮助，以改善教育、提供服务并制定干预措施，而这些都是目前所缺乏的。