Enhancing Social Competence in Adults with Autism Spectrum Disorder: A Pilot RCT

增强自闭症谱系障碍成人的社交能力：试点随机对照试验

基本信息

批准号：
10133151
负责人：
Blythe Anne Corbett
金额：
$ 49.62万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10133151
关键词：
Address Adolescent Adult Age Age-Years Anxiety Area Awareness Behavioral Centers for Disease Control and Prevention (U.S.)Child Clinical Cognitive Communities Community Services Control Groups Data Collection Development Diagnosis Effectiveness Emotional Employment Enrollment Evaluation Event-Related Potentials Face Failure Foundational Skills Goals Growth Hour Impairment Intervention Left Link Maintenance Manuals Measures Mediating Memory Mental Depression Modification Moods Motivation Neurodevelopmental Disorder Neuropsychology Outcome Participant Performance Play Randomized Research Service delivery model Services Social Behavior Social Functioning Social Interaction Stress Symptoms Techniques Testing Training Waiting Lists Youth adolescent with autism spectrum disorder adult with autism spectrum disorder autism spectrum disorder base behavioral outcome blind care costs clinical efficacy cohort community based treatment community engagement control trial evidence base experience experimental group follow-up functional outcomes improved individuals with autism spectrum disorder informant innovation neuroimaging novel peer programs psychosocial psychosocial development rehearsal relating to nervous system skills social social cognition social communication social deficits social engagement social relationships social skills supportive environment treatment effect young adult young adult with autism spectrum disorder

项目摘要

PROJECT SUMMARY Autism spectrum disorder (ASD) is characterized by primary impairment in social competence. Current psychosocial interventions for adults with ASD are lacking and urgently needed. The goal of the current proposal is to address this critical, unmet need for the development of psychosocial interventions for adults with ASD by utilizing an innovative intervention with emerging efficacy in children and adolescents with ASD. SENSE Theatre combines established behavioral techniques alongside theatrical strategies delivered in a peer- mediated, community service model with strong evidence of significant improvement in social competence. Recent findings from a randomized control trial (RCT) in youth with ASD show immediate between-group effects and evidence of target engagement on the hypothesized mechanism of action, social salience (e.g., memory for faces), evaluated by event-related potentials (ERP) and neuropsychological measures, which were linked to improvement in social interaction, social communication and adaptive functioning. While previous research has been efficacious, the objective of the application is to determine if SENSE Theatre is effective for adults with ASD at impacting social cognition, which in turn results in changes in functional clinical outcomes for adults with ASD. The proposal will develop and conduct a pilot RCT on an existing and novel psychosocial intervention explicitly tailored for adults with ASD. The intervention consists of 10 weekly sessions, 3 hours per session as well as dress/technical rehearsal and two public performances. Modifications to the current SENSE Theatre program will include: 1) having trained adult peers, 2) more age-appropriate theatrical play themes and individualized monologues (e.g., social relationships, employment), and 3) individualized character development and performance goals. The study will enroll 40 participants with high-functioning ASD 18 to 35 years of age randomized to experimental (EXP = 20) and waitlist control (WLC = 20) groups. The proposed RCT aims to: 1) assess target engagement of memory for faces, a foundational skill for social competence, using neuroimaging (ERP) and neuropsychological measures, and 2) test the link between the degree of target engagement of face memory and functional outcomes (e.g., social skills, and social interaction with novel peers). Measures will be assessed at pretest, posttest, and 2-month follow-up. The project will help achieve the goal to inform, refine and finalize a SENSE Theatre manual for adults with ASD. If predicted results occur, it will provide strong empirical support for a psychosocial intervention that has generalized and maintained effects on social competence that left untreated has significant consequences for adults with ASD.

项目概要自闭症谱系障碍 (ASD) 的主要特征是社交能力受损。目前提案的目标是缺乏针对自闭症谱系障碍成人的心理社会干预措施。的目的是解决为患有自闭症谱系障碍（ASD）的成人制定心理社会干预措施这一关键的、未得到满足的需求感觉戏剧将既定的行为技巧与在同行中提供的戏剧策略相结合。中介的社区服务模式，有强有力的证据表明社交能力显着提高。一项针对患有自闭症谱系障碍 (ASD) 青少年的随机对照试验 (RCT) 的最新结果显示了组间的直接影响以及对已发展的行动机制、社会显着性（例如记忆力）的目标参与的证据面部），通过事件相关电位（ERP）和神经心理学测量进行评估，这些测量与社交互动、社交沟通和适应功能的改善，而之前的研究则有所改善。是否有效，该应用程序的目的是确定 SENSE Theater 对患有以下疾病的成年人是否有效自闭症谱系障碍会影响社会认知，进而导致患有自闭症谱系障碍的成年人的功能性临床结果发生变化 ASD。该提案将针对现有的和新颖的心理社会干预措施制定并进行试点随机对照试验。该干预措施专为患有 ASD 的成人量身定制，每周 10 次，每次 3 小时。以及对当前 SENSE 剧院的服装/技术排练和两次公开表演。计划将包括：1）训练有素的成年同伴，2）更适合年龄的戏剧主题和个性化的独白（例如，社会关系、就业），以及3）个性化的性格该研究将招募 40 名 18 至 35 岁的高功能 ASD 参与者。年龄随机分为实验组（EXP = 20）和候补对照组（WLC = 20）。旨在：1）评估面部记忆的目标参与度，这是社交能力的基本技能，使用神经影像学 (ERP) 和神经心理学测量，2) 测试目标程度之间的联系面部记忆和功能结果的参与（例如，社交技能以及与新同伴的社交互动）。将在预测试、后测试和 2 个月的随访中评估措施，该项目将有助于实现目标。为患有自闭症谱系障碍的成人提供信息、完善和最终确定 SENSE 剧院手册。如果预测结果出现，它将实现。为社会心理干预提供强有力的实证支持，该干预措施具有普遍性和持续性的影响如果不及时治疗，社交能力会给患有自闭症谱系障碍的成年人带来严重后果。