Sphingolipid-mediated skeletal muscle pathology in response to free fatty acids.

鞘脂介导的骨骼肌病理学对游离脂肪酸的反应。

• 批准号: 7782817
• 负责人: Lauren Ashley Cowart
• 金额: --
• 依托单位: RALPH H JOHNSON VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7782817
• 关键词: Address; Age; Aging; Anabolism; Animal Model; Animals; Apoptosis; Atherosclerosis; Atrophic; Attenuated; Autophagocytosis; Behavior; Biological; Biological Assay; Biological Models; Biological Process; Cardiovascular Diseases; Caring; Cell Culture Techniques; Cells; Ceramides; Chemicals; Coupled; Data; Deposition; Diabetes Mellitus; Diet; Disease; Enzymes; Event; Exhibits; Fatty Acids; Fatty acid glycerol esters; Fibrosis; Functional disorder; Gene Deletion; Gene Expression; Gene Expression Regulation; General Population; Genes; Goals; Health; Immunoblotting; Incidence; Individual; Inflammation; Insulin Resistance; Integrated Health Care Systems; Knowledge; Label; Lipids; MAPK14 gene; Mediating; Messenger RNA; Metabolic Diseases; Metabolic Pathway; Metabolic syndrome; Metabolism; Mission; Modeling; Mus; Muscle; Muscle Fibers; Myopathy; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Organism; Outcome; PTGS2 gene; Palmitates; Pathologic Processes; Pathology; Pathway interactions; Patients; Peripheral; Persons; Phosphorylation; Physiological; Plague; Plasma; Play; Population; Prevalence; Process; Production; Regulation; Role; SKI gene; SPHK1 enzyme; Schools; Signal Pathway; Signal Transduction; Signaling Molecule; Signaling Protein; Skeletal Muscle; Specificity; Sphingolipids; System; Systems Biology; Techniques; Testing; Time; Tissues; Toxic effect; United States; Up-Regulation; Veterans; biological adaptation to stress; cell determination; cytokine; feeding; glucose uptake; inflammatory marker; inhibitor/antagonist; insight; lipid mediator; mouse model; novel; programs; public health relevance; response; sphingosine 1-phosphate; sphingosine kinase; thermozymocidin; tissue culture; wasting