Investigating Social Competence in Youth with Autism: A Multisite RCT

调查自闭症青少年的社交能力：多中心随机对照试验

• 批准号: 10063050
• 负责人: Blythe Anne Corbett
• 金额: $ 75.32万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-20 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10063050
• 关键词: Address; Age; Behavior; Behavioral; Code; Cognitive; Combined Modality Therapy; Communication; Communities; Control Groups; Delayed Memory; Emotional; Endocrinology; Event-Related Potentials; Face; Foundational Skills; Growth; Home; Impairment; Intervention; Life; Light; Link; Maintenance; Measurement; Measures; Mediating; Memory; Methodology; Methods; Modeling; Neuropsychology; Neurosciences; Outcome; Parents; Participant; Performance; Play; Probability; Randomized; Reporting; Research; Resources; Role; Sampling; Site; Social Behavior; Social Development; Social Functioning; Social Interaction; Study Subject; Symptoms; Techniques; Testing; Training; Transferable Skills; Universities; Virginia; Youth; active control; adolescent with autism spectrum disorder; autism spectrum disorder; base; behavioral outcome; blind; cohort; community based treatment; community setting; control trial; design; efficacy testing; experience; experimental group; flexibility; follow-up; functional outcomes; indexing; peer; post intervention; prevent; psychosocial; skills; social; social cognition; social communication; social deficits; social skills; treatment effect; treatment group

Autism spectrum disorder (ASD) is characterized by primary impairment in social competence. Effects of current psychosocial interventions often fail to maintain or generalize and few employ rigorous experimental methods. Our treatment, SENSE Theatre, combines several well-documented, effective behavioral strategies, such as the inclusion of trained peer models, theatre play techniques involving predictable (i.e., scripted) and flexible (improvised) role-play, and repeated performance of newly learned skills resulting in greater automaticity of behavior. Recent findings from a randomized control trial (RCT) show immediate between- group effects and evidence of target engagement on the hypothesized mechanism of action, memory for faces, which was evaluated by neuropsychological and event-related potential (ERP) measures. Moreover, the RCT demonstrated treatment effects on social communication skills that generalized to home and community settings. Finally, maintained treatment effects were observed on communication symptoms. The proposed project will extend these findings and provide a stronger test of efficacy using a multisite RCT of SENSE Theatre with a large sample of 240 participants with ASD (8 to 16 years) randomized to experimental (N = 120) and an active control group (N = 120) in 12 separate cohorts. The RCT will assess target engagement of memory for faces, a foundational skill for social competence, and functional change in social interaction with peers using examiners blind to study treatment group assignment. The significance and size of treatment effects on these cognitive and behavioral outcomes will be measured using mixed level analysis. Thus, the overarching aim of the study is to determine whether detected changes in face memory and social interaction are due to the SENSE Theatre treatment and the extent to which these changes generalize and maintain. If predicted results occur, it will provide strong empirical support for a community-based treatment that has generalized effects on a set of core deficits that otherwise have life-long consequences for youth with ASD.

自闭症谱系障碍 (ASD) 的特点是社交能力的主要障碍。的影响 当前的心理社会干预措施常常无法维持或概括，并且很少采用严格的实验 方法。我们的治疗方法 SENSE Theatre 结合了几种有据可查的有效行为策略， 例如纳入受过训练的同伴模型、涉及可预测（即有脚本）和 灵活的（即兴的）角色扮演，以及新学到的技能的重复表演，从而产生更大的效果 行为的自动性。一项随机对照试验 (RCT) 的最新发现显示， 群体效应和目标参与的证据对假设的作用机制、面孔记忆、 通过神经心理学和事件相关电位（ERP）测量进行评估。此外，随机对照试验 已证明治疗对社交沟通技能的影响可推广到家庭和社区 设置。最后，观察到对沟通症状的持续治疗效果。拟议的 项目将扩展这些发现，并使用 SENSE 的多站点 RCT 提供更强有力的功效测试 剧院有 240 名 ASD 参与者（8 至 16 岁）的大样本，随机分配到实验组 (N = 120) 以及 12 个独立队列中的活性对照组 (N = 120)。 RCT 将评估目标参与度 面孔记忆、社交能力的基本技能以及社交互动中的功能变化 使用检查者的同行不知道研究治疗组的分配。治疗的意义和规模 对这些认知和行为结果的影响将使用混合水平分析来衡量。因此， 该研究的总体目标是确定是否检测到面部记忆和社交互动的变化 这是由于 SENSE 剧院的处理方式以及这些变化的普遍化和维持的程度。如果 如果预测的结果出现，它将为基于社区的治疗提供强有力的实证支持。 对一系列核心缺陷的普遍影响，否则这些缺陷会给患有自闭症谱系障碍的青少年带来终生的后果。

项目成果

Social competence in autism: A structural equation modeling approach.

自闭症的社交能力：结构方程建模方法。

• 发表时间: 2024-04
• 作者: Simmons, G L;Corbett, B A;Lerner, M D;Wofford, K;White, S W
• 通讯作者: White, S W

Utility of an Observational Social Skill Assessment as a Measure of Social Cognition in Autism.

观察性社交技能评估作为自闭症社会认知测量的实用性。

• 发表时间: 2021
• 作者: Simmons, Grace Lee;Ioannou, Sara;Smith, Jessica V;Corbett, Blythe A;Lerner, Matthew D;White, Susan W
• 通讯作者: White, Susan W

Peers, play, and performance to build social salience in autistic youth: A multisite randomized clinical trial.

通过同伴、游戏和表现来建立自闭症青少年的社会显着性：一项多中心随机临床试验。

• DOI: 10.1037/ccp0000821
• 发表时间: 2023-05-18
• 期刊: Journal of consulting and clinical psychology
• 影响因子: 5.9
• 作者: B. Corbett;S. White;M. Lerner;Kristopher J Preacher;Marko Klemenčić;G. L. Simmons;Jennifer Pilkington
• 通讯作者: Jennifer Pilkington

Camouflaging in Autism: Examining Sex-Based and Compensatory Models in Social Cognition and Communication.

自闭症的伪装：检查社会认知和沟通中基于性别的补偿模型。

• 发表时间: 2021
• 作者: Corbett, Blythe A;Schwartzman, Jessica M;Libsack, Erin J;Muscatello, Rachael A;Lerner, Matthew D;Simmons, Grace L;White, Susan W
• 通讯作者: White, Susan W

Brief Report: The Influence of Autism Severity and Depression on Self-Determination Among Young Adults with Autism Spectrum Disorder.

简要报告：自闭症严重程度和抑郁对患有自闭症谱系障碍的年轻人的自我决定的影响。

• 发表时间: 2022-06
• 影响因子: 3.9
• 作者: White, Susan W;Smith, Isaac;Brewe, Alexis M
• 通讯作者: Brewe, Alexis M