Cardiovascular Benefits of Inhaled Biogenic Volatile Organic Compounds

吸入生物挥发性有机化合物对心血管的益处

基本信息

批准号：
10459548
负责人：
Daniel Joseph Conklin
金额：
$ 19.56万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10459548
关键词：
ANK1 gene Acute Adult Affect Aggressive behavior Air Pollutants Anti-Inflammatory Agents Antiinflammatory Effect Anxiety Attention Blood Pressure Blood Vessels Cardiac Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Cell physiology Cells Chemical Exposure Chrysanthemum Cypress Data Doctor of Philosophy Endothelial Cells Endothelium Environment Environmental Risk Factor Epidemiology Eucalyptol Exposure to Female Frequencies Future Green space Health Heart Rate Human Inflammation Inflammatory Inhalation Intravenous Juniper Knowledge Lead Life Style Link Malignant Neoplasms Mass Spectrum Analysis Mediating Mental Depression Metabolism Molecular Monoterpenes Mus National Institute of Environmental Health Sciences Neurologic Effect Nitric Oxide Oral Pathway interactions Pharmacology Physical activity Physiological Plants Population Principal Investigator Production Radio Rattus Risk Role Screening procedure Shapes Signal Pathway Signal Transduction Sleep Stress TRPA channel Telemetry Testing Therapeutic Uses Thrombosis Time Trees United States Vasodilation Work aerosolized anti-cancer biomarker development blood pressure reduction cardioprotection cardiovascular disorder risk cardiovascular effects cardiovascular health dosimetry heart rate variability hemodynamics hypertensive improved in vitro Assay indoor air interest lifestyle factors limonene linalool male mortality normotensive preclinical study prevent programs receptor research clinical testing urinary volatile organic compound

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Conklin, Daniel J., Ph.D. ABSTRACT Extensive epidemiological evidence suggests that exposure to vegetation and residential proximity to greenspaces lowers the risk of all-cause mortality, cardiovascular disease, anxiety, depression and aggression. Although it has been suggested that urban greenspaces exert their beneficial effects by removing air pollutants and promoting physical activity, plants emit biogenic volatile organic chemicals (BVOCs), which by eliciting beneficial cardiovascular and neurological effects could mediate the salutary effects of vegetation. Vegetation is a major underappreciated domain of the natural environment that has received limited interest. Exposure to greenspace within the natural environment has been linked to improvements in cardiovascular health. We propose that plant-derived BVOCs including pinenes, limonene, and citronellol stimulate distinct signaling pathways, in part, by activating the transient receptor potential ankyrin-1 (TRPA1) channel on cardiovascular targets. In endothelial cells, for example, activation of TRPA1 releases nitric oxide that lowers blood pressure, improves cardiovascular function and tamps down inflammation and thrombosis leading to an overall decrease in cardiovascular disease risk. Completion of this project will rigorously establish beneficial cardiovascular effects of inhaled BVOCs that are prevalent in human environments. Moreover, our studies will provide a first test of hypothesis that beneficial effects of inhaled BVOCs are mediated, in part, by TRPA1. These preclinical studies may also lead to the development of biomarkers of exposure to greenness, which likely will be useful in clinical evaluation of the potential therapeutic use of greenness (e.g., planting trees) to decrease CVD risk in human populations. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目总监/首席研究员（最后、第一、中间）：Conklin, Daniel J., Ph.D. 抽象的广泛的流行病学证据表明，暴露于植被和居住地附近绿色空间可以降低全因死亡率、心血管疾病、焦虑、抑郁和攻击性的风险。尽管有人认为城市绿地通过去除空气污染物来发挥其有益作用植物排放生物挥发性有机化学物质 (BVOC) 并促进身体活动，通过引发有益的心血管和神经系统作用可以介导植物的有益作用。植被是自然环境中一个未被充分认识的主要领域，人们的兴趣有限。接触自然环境中的绿色空间与心血管健康的改善有关。我们提出植物衍生的 BVOC（包括蒎烯、柠檬烯和香茅醇）可刺激不同的信号传导部分通过激活心血管上的瞬时受体电位锚蛋白-1 (TRPA1) 通道目标。例如，在内皮细胞中，TRPA1 的激活会释放一氧化氮，从而降低血压，改善心血管功能并抑制炎症和血栓形成，从而整体降低心血管疾病风险。该项目的完成将严格确定对心血管的有益作用人类环境中普遍存在的吸入 BVOC。此外，我们的研究将提供第一次测试假设吸入 BVOC 的有益作用部分是由 TRPA1 介导的。这些临床前研究还可能导致暴露于绿色的生物标志物的开发，这可能在临床上有用评估绿色（例如植树）降低人类心血管疾病风险的潜在治疗用途人口。 PHS 398/2590（修订版 06/09）页面延续格式页面