Scale it up: Effectiveness-implementation research to enhance HIV-related self-management among youth

扩大规模：加强青少年艾滋病毒相关自我管理的有效性实施研究

• 批准号: 10459959
• 负责人: SYLVIE NAAR
• 金额: $ 114.74万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10459959
• 关键词: AIDS prevention; Address; Adherence; Administrative Supplement; Anti-Retroviral Agents; Caring; Communities; Coupled; Effectiveness; Ensure; Exploration, Preparation, Implementation, and Sustainment; Foundations; Funding; Goals; HIV; HIV Seronegativity; Human immunodeficiency virus test; Intervention; Longevity; Mediating; Methods; Modeling; Prevention; Prevention strategy; Process; Research; Research Project Grants; Risk; Safe Sex; Science; Self Management; Site; Testing; Time; Youth; age group; base; cost effectiveness; design; effectiveness implementation study; efficacious intervention; implementation intervention; implementation research; implementation science; improved; intervention effect; pre-exposure prophylaxis; programs; tool; transmission process

Abstract Despite the substantial declines in HIV transmission and increases in lifespan among those living with HIV achieved over the past decade, full benefits that should be possible based on the tools and interventions currently available have yet to be realized in youth, in large part because efficacious interventions for this age group have not been brought to scale. To be effective, youth must be fully engaged in interventions at every stage of the HIV care (treatment and prevention) cascades: HIV testing, linkage to care, timely initiation of care, persistence and adherence to antiretroviral care. At-risk HIV-negative youth need to be consistently engaged in prevention strategies such as PEP and/or PrEP as indicated, consistent safer sex practices and repeat HIV testing. Our U19 project - Scale It Up - specifically focuses on the process of improving self- management among youth including: 1) the identification of interventions that are efficacious and effective for improving self-management in YLH and at risk youth; 2) the multi-site implementation of an intervention shown to be efficacious in improving self-management; and 3) the assessment of the Five Components of Self- Management Model and how these vary over time, are directly improved by interventions, and mediate intervention effects. Our team has also been at the leading edge of implementation Science research related to HIV prevention and care. We are actively committed to aggressively moving beyond simple efficacy and effectiveness RCTs. The four Research Projects proposed in Scale It Up, all addressing self-management, will continue to develop the field of Implementation Science by employing three types of effectiveness- implementation hybrid designs. The studies further synergize by utilizing Aaron’s Exploration, Preparation, Implementation, Sustainment (EPIS) model to guide the proposed Implementation Science efforts. Our proposed Implementation Science Core, coupled with the cost effectiveness expertise of our Analytic Core, will be focused on the central notion of “Scale It Up” – taking efficacious self-management interventions and expeditiously moving them into practice while sustaining effectiveness. Scale It Up has assembled research teams who will develop, test, and bring to practice self-management interventions that positively impact the youth HIV prevention and care cascades. We will achieve these goals by: 1) Designing, conducting and evaluating self-management interventions grounded in the 5-component Self-Management Model and expeditiously moving effective programs into practice; 2) Developing, deploying and disseminating new methods for implementation and implementation analysis with a strong theoretical foundation; and 3) Engaging with the other funded U19s to identify additional opportunities to advance the implementation science and self- management science. Project Summary/Abstract Page 200

抽象的 尽管艾滋病毒传播大幅下降，感染者的寿命延长 艾滋病毒在过去十年中取得的成果，基于工具和干预措施应该可以实现的全部效益 目前可用的措施尚未在青年中实现，很大程度上是因为针对这个年龄段的有效干预措施 小组尚未形成规模。为了发挥作用，青年人必须充分参与每一次干预。 HIV 护理（治疗和预防）级联阶段：HIV 检测、与护理的联系、及时启动 需要始终如一地对高危艾滋病毒阴性青少年进行护理、坚持和坚持抗逆转录病毒治疗。 参与预防策略，例如所指出的 PEP 和/或 PrEP，一致的安全性行为做法，以及 我们的 U19 项目 - Scale It Up - 特别关注改善自我的过程。 对青少年的管理包括： 1) 确定有效且有效的干预措施 改善 YLH 和高危青少年的自我管理；2) 多地点实施干预措施 有效改善自我管理；以及 3) 自我管理的五个组成部分的评估 管理模型以及这些模型如何随时间变化，通过干预措施直接改进，并​​进行调解 我们的团队在实施相关科学研究方面也处于领先地位。 我们积极致力于超越简单的功效和护理。 Scale It Up 中提出的四个研究项目均针对自我管理，将进行有效性随机对照试验。 通过采用三种类型的有效性，继续发展实施科学领域—— 这些研究通过利用亚伦的探索、准备、 实施、维持（EPIS）模型，用于指导拟议的实施科学工作。 拟议的实施科学核心，加上我们分析核心的成本效益专业知识，将 专注于“扩大规模”的核心概念——采取有效的自我管理干预措施 Scale It Up 收集了研究成果，并迅速将其付诸实践。 团队将开发、测试并实践自我管理干预措施，以积极影响 我们将通过以下方式实现这些目标： 1) 设计、领导和关怀。 评估基于 5 个组成部分的自我管理模型的自我管理干预措施，以及 迅速将有效的计划付诸实践； 2) 开发、部署和传播新的计划； 具有坚实理论基础的实施方法和实施分析；以及 3) 参与性 与其他受资助的 U19 一起寻找更多机会来推进实施科学和自我 管理科学。 项目总结/摘要第 200 页

项目成果

Impact of the COVID-19 Pandemic on the Care Continuum of Youth Living with HIV: Qualitative Study of the Scale It Up Program Clinical Sites.

COVID-19 大流行对感染艾滋病毒的青少年护理连续性的影响：对 Scale It Up 计划临床地点的定性研究。

• 发表时间: 2022-12
• 影响因子: 4.4
• 作者: Dark, Tyra;Gurung, Sitaji;Dooley, Mary;Simpson, Kit N;Butame, Seyram A;Naar, Sylvie
• 通讯作者: Naar, Sylvie

Mechanisms of Successful Implementation of Tailored Motivational Interviewing in a Multisite Study of Youth HIV Clinics in the United States.

在美国青年艾滋病诊所多地点研究中成功实施定制动机访谈的机制。

• 发表时间: 2023-12-01
• 作者: Naar, Sylvie;Kimball, Devon;Cain, Demetria;Pooler, Meardith;Rambo, Shane;Chapman, Jason;MacDonell, Karen;Lin Miller, Robin
• 通讯作者: Lin Miller, Robin

Feasibility of Using Electronic Health Records for Cascade Monitoring and Cost Estimates in Implementation Science Studies in the Adolescent Trials Network for HIV/AIDS Interventions.

在青少年艾滋病毒/艾滋病干预试验网络实施科学研究中使用电子健康记录进行级联监测和成本估算的可行性。

• 发表时间: 2022-04-25
• 影响因子: 2.2
• 作者: Dark, Tyra;Simpson, Kit N;Gurung, Sitaji;Pennar, Amy L;Chew, Marshall;Naar, Sylvie
• 通讯作者: Naar, Sylvie

Synthesizing Adaptive Digital Bioethics to Guide the Use of Interactive Communication Technologies in Adolescent Behavioral Medicine: A Systematic Configurative Review.

综合自适应数字生物伦理学来指导交互式通信技术在青少年行为医学中的使用：系统配置审查。

• 发表时间: 2022-08
• 影响因子: 2.6
• 作者: Skeen, Simone J;Shaw Green, Sara K;Knopf, Amelia S
• 通讯作者: Knopf, Amelia S

Adolescent Male Couples-Based HIV Testing Intervention (We Test): Protocol for a Type 1, Hybrid Implementation-Effectiveness Trial.

基于青少年男性夫妇的 HIV 检测干预（我们测试）：1 类混合实施-有效性试验方案。

• 发表时间: 2019-06-07
• 影响因子: 1.7
• 作者: Starks, Tyrel J;Feldstein Ewing, Sarah W;Lovejoy, Travis;Gurung, Sitaji;Cain, Demetria;Fan, Carolyn A;Naar, Sylvie;Parsons, Jeffrey T
• 通讯作者: Parsons, Jeffrey T