Methods for Early Phase Translation of Basic Science into Behavioral Treatments to Improve Health

将基础科学早期转化为行为治疗以改善健康的方法

基本信息

批准号：
10418074
负责人：
SYLVIE NAAR
金额：
$ 20.95万
依托单位：
FLORIDA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10418074
关键词：
Address Adult Attention Basic Behavioral and Social Science Research Basic Science Behavior Therapy Behavioral Behavioral Research Cancer Prevention Trial Cardiovascular Diseases Chronic Disease Clinical Trials Design Consultations Control Groups Course Content Creativeness Development Diabetes Mellitus Discipline Dose Drops Educational Curriculum Educational process of instructing Educational workshop Ensure Evaluation Exposure to Faculty Goals Grant Health Health Care Costs Health Promotion Health behavior Intervention Intervention Studies Knowledge Learning Link Malignant Neoplasms Mentors Methodology Methods Minority Modeling Participant Persons Phase Process Public Health Practice Publications Qualitative Evaluations Quantitative Evaluations Questionnaires Research Personnel Risk Factors Sampling Scientist Smoking Specific qualifier value Surveys Techniques Technology Time Trainers Training Training Translational Research Translations Unhealthy Diet United States National Institutes of Health Work aged attributable mortality base behavioral/social science bench to bedside cancer prevention cancer therapy career clinical practice course development curriculum development design drug development effective therapy efficacy testing follow-up improved innovation interest investigator training lectures literacy model development modifiable risk mortality premature prevent programs public health priorities recruit sedentary lifestyle skill acquisition skills social science research success therapy design therapy development treatment optimization web site webinar

项目摘要

PROJECT SUMMARY To strengthen behavioral interventions for improve health, as in cancer prevention and treatment, and increase their dissemination into clinical practice, what is needed is: (1) more attention to phased T1 translation from basic behavioral and social sciences research to applied behavioral intervention development; and (2) more focus on early-phase treatment development by promoting the use of new and innovative methodologies to answer commonly asked questions about basic treatment design. This skills development course aims to train 100 intervention scientists (Fellows) at any academic rank but who have an interest in behavioral treatment development to target cancer and related health behaviors. Training will take place over 6 months including a 3-day workshop followed by bi weekly webinars with 25 Fellows per session. Learning will be multi-directional and will feature didactic, interactive, and applied teaching techniques. A train-the-trainer model is integrated throughout the course. Optional follow-up activities include consultation and mentoring with faculty. The curriculum will be offered by expert faculty who will teach a phased approach to intervention development, new and innovative methods that are well-suited to answer common questions that arise during health behavior treatment development. Among the methodologies are dose-finding methods, mixed methods to maximize ecological validity of treatments, approaches for small samples, tailoring and adaptive treatments, and methods to determine the timing and choice of appropriate control groups. The Specific Aims of the course are: 1) To successfully recruit and train 100 Fellows dedicated to behavioral interventions relevant for cancer prevention/treatment and related health behaviors over the 4-year grant period, with substantial minority representation (25 Fellows per year); 2) To increase the skills of Fellows in a phased approach, with associated innovative methods and designs for T1 translation of BSSR. 3) To conduct an ongoing evaluation of the success of the skills development course based upon three basic metrics: (a) perceived value; (b) the reach of the course based upon website hits, number of applications, and train the trainer activities; and (c) the impact of the course on the career trajectories of the Fellows (publications, grants). 4) To conduct ongoing curriculum development and refinement, as well as dissemination via technology, based upon results of quantitative and qualitative evaluations and new methodologies emerging over the grant period.

项目概要加强行为干预以改善健康，例如癌症预防和治疗，以及增加其在临床实践中的传播，需要的是：（1）更加关注阶段性T1 从基础行为和社会科学研究到应用行为干预的转化发展; (2) 通过推广新疗法的使用，更加注重早期治疗的开发和创新方法来回答有关基本治疗设计的常见问题。这技能发展课程旨在培训 100 名任何学术级别的干预科学家（研究员），但对针对癌症和相关健康的行为治疗开发感兴趣的人行为。培训将持续 6 个月以上，包括为期 3 天的研讨会，随后每周举行两次每场有 25 名研究员的网络研讨会。学习将是多方向的，并以说教为特色，互动式、应用式教学技术。培训师培训模型已集成到整个过程中课程。可选的后续活动包括与教师的咨询和指导。该课程将由专家教师提供，他们将教授干预措施开发的分阶段方法、新的和非常适合回答健康行为过程中出现的常见问题的创新方法治疗的发展。这些方法包括剂量探索方法、混合方法最大限度地提高治疗的生态有效性、小样本方法、定制和适应性治疗方法以及确定适当对照组时间和选择的方法。具体该课程的目标是： 1) 成功招募和培训 100 名致力于行为学的研究员四年内与癌症预防/治疗和相关健康行为相关的干预措施资助期，有大量少数族裔代表（每年 25 名研究员）； 2) 提高技能研究员采用分阶段方法，以及 T1 翻译的相关创新方法和设计 BSSR。 3) 对技能发展课程的成功进行持续评估基于三个基本指标：(a) 感知价值； (b) 基于网站点击率的课程覆盖范围，申请数量、培训师活动等； (c) 课程对职业的影响研究员的轨迹（出版物、资助）。 4) 进行持续的课程开发和根据定量和定性结果进行细化和通过技术进行传播资助期间出现的评估和新方法。