Core 5: Integrated Support Services

核心 5：综合支持服务

• 批准号: 10447708
• 负责人: RONALD B CORLEY
• 金额: $ 207.64万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10447708
• 关键词: Accreditation; Address; Anatomy; Animal Experimentation; Animal Model; Animal Technicians; Animals; Autopsy; Basic Science; Biotechnology; Boston; Cells; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical; Clinical Chemistry; Collaborations; Communities; Comparative Pathology; Competence; Containment; Development; Diagnostic; Emerging Communicable Diseases; Ensure; Equipment and supply inventories; Faculty; Fees; Fees and Charges; Flow Cytometry; Fostering; Funding; Future; Goals; IACUC; Image; Immunology; Individual; Infectious Agent; Infectious Diseases Research; Infrastructure; Institution; International; Laboratories; Libraries; Light; Link; Maintenance; Methodology; Methods; Microscopy; Monitor; Outcome; Pathologist; Pharmacologic Substance; Private Sector; Procedures; Protocols documentation; Reagent; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Safety; Sampling; Sampling Studies; Schedule; Science; Scientific Inquiry; Scientist; Services; Specimen; Technical Expertise; Technology; Therapeutic; Time; Tissues; Training; Universities; Vaccines; Veterinary Pathology; Viral; Virus; Visual; Work; comparative; cost; frontier; high throughput screening; innovation; instrumentation; operation; pathogen; programs; recruit; research and development; response; screening; single cell sequencing; small molecule inhibitor; tool; translational research program; viral genomics; virology

Core 5: Integrated Research Support Services Abstract The Integrated Research Support Services (ISS) Core serves to organize shared services that are provided to the research community within the NEIDL. These services support BSL-4/ABSL-4 studies to ensure that each investigator does not have to recreate infrastructure and expertise in their laboratories in order to carry out their funded research programs. The core will develop schedules and manage costs so that reasonable and responsible user fees are charged to investigators using these services to offset overall costs, as appropriate. The services offered evolve over time such that new services can be offered as the needs of the research community changes. Currently, core is broadly separated into the Animal Research Support Services, and the BSL-4 Laboratory Services. Animal Research Services includes trained veterinary professionals and veterinary technicians who collaborate with faculty to carry out studies in various animal models. The team is trained on a number of procedures to increase safety when working with animals, especially those that require the use of sharps. This unit also works with investigators to ensure the humane use of animals and to comply with institutional animal care and use committee requirements. Within the BSL-4 Laboratory Services, a number of units exist to support the BSL-4 and ABSL-4 studies. These include Veterinary Pathology (anatomic and laboratory) Service which oversees the necropsy services, storage and maintenance of the samples in compliance with the CDC select agent program, and is responsible for establishing and validating the inactivation protocols required to move tissues to the BSL-2. The Veterinary Pathologist is responsible for clinical chemistry. Virology Services is responsible for receiving, validating, and inventorying viruses that are utilized in BSL-4 research. This includes generating master and working stocks as well as maintaining an accurate inventory of agents. This core also develops advanced virologic tools as needed. The Viral Genomic Tracking and Single Cell omics Resource is responsible for ensuring the fidelity of viral stocks from VS given to investigators for their research, and for initiating single cell sequencing and single virus omics technologies in the BSL-4. The Imaging Services Unit provides several platforms to study living tissue specimens infected with BSL-4 pathogens, including Light Sheet microscopy. Many of the BSL-4 investigators rely on services from the NEIDL Comparative Pathology Laboratory (NCPL). Immunology Services provides training, guidance and maintenance of advanced immunology instrumentation inside the BSL-4 footprint, including flow cytometry. High-throughput screening has been operationalized to include automated visual screening of virus infected cells treated with small molecule inhibitors, and can be adapted to any virus or cell target. Linking the Clinic to NEIDL Programs includes a clinician whose responsibilities are to link clinical outcomes to the studies that are undertaken in the NEIDL (for comparative purposes) as well as to engage with clinical programs to obtain clinical samples for studies.

核心 5：综合研究支持服务 抽象的 综合研究支持服务 (ISS) 核心用于组织提供给以下人员的共享服务： NEIDL 内的研究团体。这些服务支持 BSL-4/ABSL-4 研究，以确保每个 研究人员不必在实验室中重建基础设施和专业知识来开展他们的研究 资助的研究项目。核心将制定时间表并管理成本，以便合理和 酌情向使用这些服务的调查人员收取负责任的用户费用，以抵消总体成本。 所提供的服务随着时间的推移而发展，以便可以根据研究的需要提供新的服务 社区变化。目前，核心大致分为动物研究支持服务和 BSL-4 实验室服务。动物研究服务包括训练有素的兽医专业人员和兽医 与教师合作对各种动物模型进行研究的技术人员。该团队接受过培训 提高动物工作安全性的程序数量，尤其是那些需要使用 锐器。该部门还与调查人员合作，确保人道地使用动物并遵守 机构动物护理和使用委员会的要求。在 BSL-4 实验室服务中，许多 单位的存在是为了支持 BSL-4 和 ABSL-4 研究。其中包括兽医病理学（解剖学和 实验室）监督尸检服务、样品储存和维护的服务 遵守 CDC 选择代理计划，并负责建立和验证 将组织转移至 BSL-2 所需的灭活方案。兽医病理学家负责 临床化学。病毒学服务负责接收、验证和盘点病毒 用于 BSL-4 研究。这包括生成主库存和工作库存以及维护 准确的代理商库存。该核心还根据需要开发先进的病毒学工具。病毒基因组 跟踪和单细胞组学资源负责确保 VS 提供的病毒库存的保真度 研究人员的研究，以及启动单细胞测序和单病毒组学技术 BSL-4。成像服务部门提供了多个平台来研究感染了病毒的活体组织标本 BSL-4 病原体，包括光片显微镜。许多 BSL-4 调查人员依赖于以下机构的服务： NEIDL 比较病理学实验室 (NCPL)。免疫学服务提供培训、指导和 维护 BSL-4 足迹内的先进免疫学仪器，包括流式细胞术。 高通量筛查已投入使用，包括对感染病毒的自动视觉筛查 用小分子抑制剂处理的细胞，可以适应任何病毒或细胞靶标。将诊所链接至 NEIDL 计划包括一名临床医生，其职责是将临床结果与以下研究联系起来： 在 NEIDL 中进行（出于比较目的）以及参与临床项目以获得 用于研究的临床样本。