National Emerging Infectious Diseases Laboratories Operations

国家新发传染病实验室运营

基本信息

批准号：
9075446
负责人：
RONALD B CORLEY
金额：
$ 1150万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-01 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9075446
关键词：
Accounting Advanced Development Animal Model Animals Area Attention Award Basic Science Boston Businesses Categories Clinical Research Collaborations Communication Communities Comparative Study Containment Development Diagnosis Diagnostic Diagnostic tests Discipline Emergency Situation Emerging Communicable Diseases Ensure Environment Environmental Health Epidemiology Event Evolution Faculty Goals Government Human Human Resources Infection Infectious Agent Infectious Diseases Research Institutes International Knowledge Laboratories Lead Maintenance Medical Methodology Mission Monitor National Institute of Allergy and Infectious Disease Nature Pathogenesis Pharmacotherapy Prevention strategy Preventive Process Productivity Public Health Recovery Recruitment Activity Research Research Activity Research Personnel Research Support Safety Science Scientist Secure Security Services Strategic Planning Therapeutic Training Training Activity Translational Research Universities Update Vaccines Virulence Work biodefense biosecurity cost flexibility human disease improved laboratory experiment laboratory facility microbial operation pathogen pre-clinical research programs public health relevance research facility response technology development therapeutic vaccine tool vaccine evaluation

项目摘要

DESCRIPTION (provided by applicant): Overall: Summary The National Biocontainment Laboratory (NBL) at Boston University is known as the National Emerging Infectious Diseases Laboratories (NEIDL). The NEIDL is owned and operated by Boston University (BU) and is located on the Boston University Medical Campus (BUMC). The NEIDL's missions are: 1. To perform cutting- edge basic, translational and clinical research on emerging infectious diseases, including category A, B, and C agents, in order to develop diagnostic tests, treatments and vaccines to promote the public's health; 2. To provide training in these areas of research and to support a national response in the event of a biodefense emergency; and 3. To establish a research facility with the highest attention to community and laboratory safety and security. In order to successfully achieve these missions, the NEIDL's goals are to: 1) Recruit and develop a cadre of investigators and research staff with expertise in the scientific disciplines required to investigate the pathogenesis of emerging infectious diseases caused by category A, B and C agents; 2) Develop animal models for the comparative study of these pathogens, mimicking as closely as possible the human disease process; 3) Perform translational, preclinical and clinical research in animals and humans; 4) Develop the methodologies needed to advance the development and testing of vaccines, therapeutics and diagnostics for these agents; 5) Train scientists and related support personnel in the requirements to perform maximum containment research in a safe and secure environment; 6) Maintain the flexibility needed to support a national response in the event of a biodefense emergency; 7) Establish a "safety first" environment for the conduct of all activities i the Institute.

描述（由申请人提供）：总体：总结波士顿大学国家生物防护实验室 (NBL) 被称为国家新发传染病实验室 (NEIDL)。NEIDL 由波士顿大学 (BU) 拥有和运营，位于波士顿大学医学校区 (BUMC)。 NEIDL 的使命是： 1. 对新出现的传染病（包括 A、B 和 C 类病原体）进行前沿的基础、转化和临床研究，以开发诊断测试、治疗方法和疫苗，促进公众健康； 2. 提供这些研究领域的培训，并支持发生生物防御紧急情况时的国家应对措施；以及 3. 建立高度重视社区和实验室安全和安保秩序的研究设施。为了成功实现这些使命，NEIDL 的目标是： 1) 招募和培养一支具有调查 A、B 和 C 类病原体引起的新发传染病发病机制所需的科学学科专业知识的调查人员和研究人员骨干队伍； 2) 开发用于比较研究这些病原体的动物模型，尽可能模仿人类疾病过程； 3) 在动物和人类中进行转化、临床前和临床研究； 4) 开发推进开发和测试所需的方法；这些药物的疫苗、治疗方法和诊断方法； 5) 对科学家和相关支持人员进行培训，使其了解在安全可靠的环境中进行最大限度的遏制研究的要求； 6) 保持在发生生物防御时支持国家应对措施所需的灵活性； 7) 为研究所的所有活动建立“安全第一”的环境。