ALZHEIMER DISEASE RESEARCH CENTER

阿尔茨海默病研究中心

• 批准号: 3104730
• 负责人: ROBERT Y. MOORE
• 金额: $ 108.35万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3104730
• 关键词: Alzheimer's disease

The Alzheimer's Disease Research Center (ADRC) at the University of Pittsburgh was established in 1985 as a mechanism for integrating, coordinating and supporting new and ongoing research in Alzheimer's disease (AD) and aging. The present proposal is a request for a 5 year renewal of the ADRC. The goal of the ADRC for the next 5 years is to provide core support for investigators and has three principle objectives. The first objective is to support and foster research into the cellular and molecular neurobiology of AD with specific reference to understanding the cellular, metabolic and molecular changes that could mediate the pathological, physiological and clinical abnormalities. This goal will be approached with studies which will investigate: A) membrane metabolic and molecular dynamics in AD and control erythrocytes (Project #2, Pettegrew) as compared to clinical symptomatology and in vivo 31P NMR findings in brain (NIA- funded, Pettegrew); B) the structural and functional comparison of beta- amyloid and epidermal growth factor peptides (Pilot Project #1, Klunk); C) excitatory amino acid transmitters and receptors in pyramidal cells and the relationship of this system to the pathology and symptomatology of AD (Project #4); D) tyrosine hydroxylase-immunoreactive neocortical neurons and their role in AD, Parkinson's and diffuse Lewy body disease (Project #5, Lewis); and E) possible pharmacokinetic mechanisms to explain the high incidence of adverse drug reactions in AD (Pilot Project #4, Perel). The second objective is to support and foster research directed at understanding the clinical syndrome of AD with specific reference to functional dissociations. This goal will be approached with studies which will investigate: A) measures of cognitive slowing in patients who present with mixed symptoms of depression and dementia (Project #1, Nebes); B) SPECT imaging of frontal and temporal cortex as a predictor of short versus long-term memory loss (Pilot Project #5, Becker); C) the effect of sleep apnea on cognitive, affective and behavioral functioning in AD (Pilot Project #3, Hoch); D) computer simulation of characteristics of dementia as compared to depression (Pilot Project #8, Webster); and E) the merits of a didactic, interactive, educational approach to educate and induce changes in caregiver knowledge, attitudes and behavior. The third goal is to support and foster mechanisms for the delivery of information generated by the Center to all ADRC investigators and to clinicians and investigators outside the University setting.

阿尔茨海默氏病研究中心（ADRC） 匹兹堡成立于1985年，是整合的机制 协调和支持阿尔茨海默氏病的新研究和正在进行的研究 （AD）和衰老。 本提案是要求续签5年的要求 ADRC。 接下来5年的ADRC的目标是提供核心 支持调查人员，并具有三个主要目标。 第一个 目的是支持和促进对细胞和分子的研究 AD的神经生物学，特别是了解细胞， 代谢和分子变化，可以介导病理学， 生理和临床异常。 这个目标将接触到 通过研究的研究：a）膜代谢和分子 AD和控制红细胞的动力学（项目＃2，Pettegrew）比较 在临床症状学和体内31p NMR的发现（NIA- 资助，Pettegrew）； b）β-的结构和功能比较 淀粉样蛋白和表皮生长因子肽（试点项目＃1，klunk）; c） 兴奋性氨基酸发射器和受体中的受体和受体 该系统与AD的病理和症状的关系 （项目＃4）; D）酪氨酸羟化酶 - 免疫反应性新皮质神经元 以及它们在AD，帕金森氏症和弥漫性路易疾病中的作用（项目 ＃5，刘易斯）； e）可能的药代动力学机制来解释高 AD中不良药物反应的发生率（Pilot Project＃4，Perel）。 这 第二个目标是支持和培养针对的研究 了解AD的临床综合征，具体参考 功能解离。 将通过研究实现此目标 将调查：a）出现患者认知放缓的度量 抑郁症和痴呆症的混合症状（项目＃1，NEBES）； b） 额叶和颞皮层的SPECT成像作为短与颞叶的预测因子 长期记忆丧失（贝克尔飞行员项目＃5）； c）睡眠的影响 AD中认知，情感和行为功能的呼吸暂停（飞行员 项目＃3，Hoch）; d）计算机模拟痴呆特征作为 与抑郁症相比（韦伯斯特飞行员项目＃8）； e） 教育和诱导变革的教学，互动，教育方法 在照顾者知识，态度和行为上。 第三个目标是 支持和寄养机制，用于传递由 所有ADRC调查人员以及临床医生和研究人员的中心 在大学环境之外。