CENTER FOR FUNCTIONAL BRAIN IMAGING

脑功能成像中心

• 批准号: 2249187
• 负责人: ROBERT Y. MOORE
• 金额: $ 38.22万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2249187
• 关键词: biomedical facility; brain imaging /visualization /scanning; neuroanatomy; positron emission tomography

The primary aim of the Center for Functional Brain Imaging at the University of Pittsburgh Medical Center is to substantially expand existing clinical and basic research programs in mental disorders by the judicious introduction of PET functional brain imaging. This Center will provide the infrastructure for the initiation of a diverse group of new research projects using PET to study mental disorders. These projects include: correlation of magnetic resonance spectroscopy abnormalities to regional changes in glucose metabolism and blood flow in aged, demented, schizophrenic and autistic patient groups; measuring regional brain function after serotonergic pharmacological challenges in obsessive-compulsive and suicidal patients; development of new cognitive tasks for specific activation of frontal lobe regions; studying metabolic changes after sleep deprivation in normal aged and depressed populations; combining event-related potential data with regional activation seen by PET to elucidate the basis for shifting attention; measuring D2 receptor occupancy in cortical structures during controlled neuroleptic therapy of schizophrenics; correlation of focal mesial-temporal metabolic defects to clinical courses of demented patients; determination of frontal lobe dysfunction in young patients with anti-social personalities; and examining the metabolic consequences of sub-cortical white matter MRI hyperintensity lesions in elderly depressives. This group of proposals all arise from investigators in funded psychiatry and psychology research groups who bring considerable expertise to each project and carefully characterized patient populations. The inclusion in the Neurocognitive Core of key investigators in the Department of Psychology at Carnegie Mellon University and the development of collaborative projects further enriches the Center and the proposed research. We believe that the integration of novel, experimental and clinical paradigms with straightforward, established PET techniques is the most logical approach for achieving the initial aims of this Center. The availability of new receptor ligand tracers through the radiochemistry group will create the basis for the next phase of clinical imaging research in the Center.

功能性脑成像中心的主要目的 匹兹堡大学医学中心将大大扩展 现有的精神疾病临床和基础研究计划 明智地引入宠物功能性脑成像。 这个中心会 提供基础设施，以启动一群新的群体 研究项目使用PET研究精神障碍。 这些项目 包括：磁共振光谱异常与 老化，痴呆，葡萄糖代谢和血流的区域变化 精神分裂症和自闭症患者组；测量区域大脑 血清素能药理学挑战之后的功能 强迫症和自杀患者；新认知的发展 额叶区域特定激活的任务；研究代谢 正常年龄和抑郁症的睡眠剥夺后的变化； 将与事件相关的潜在数据与区域激活相结合 宠物阐明转移注意力的基础；测量D2受体 在受控神经疗法期间皮质结构的占用率 精神分裂症患者；局灶性周期代谢缺陷与 痴呆患者的临床课程；额叶的确定 具有反社会个性的年轻患者的功能障碍；和 检查亚皮质白质MRI的代谢后果 老年人抑郁剂中的高强度病变。 这组提案 全部来自资助的精神病学和心理学研究的研究者 为每个项目带来大量专业知识并仔细的团体 表征患者人群。 神经认知的包含 卡内基心理学系主要研究人员的核心 梅隆大学和协作项目的发展 丰富了中心和拟议的研究。 我们相信 将新颖，实验和临床范式的整合与 直接，建立的宠物技术是最合乎逻辑的方法 实现该中心的最初目标。 新的可用性 通过放射化学组的受体配体示踪剂将创建 中心临床成像研究的下一阶段的基础。