Nutrition Precision Health for All of Us (Chicago Center)

为我们所有人提供营养精准健康（芝加哥中心）

基本信息

批准号：
10385943
负责人：
Briseis A Aschebrook-Kilfoy
金额：
$ 109.21万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-10 至 2026-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10385943
关键词：
Adherence Algorithms All of Us Research Program Behavioral Beverages Bioinformatics Biological Biological Markers Black Populations Blood Pressure Calories Cardiovascular Diseases Cardiovascular system Cerebrovascular Disorders Chicago Cities Clinic Visits Clinical Clinical Research Collaborations Communities Complex Consent Controlled Environment DASH diet Data Data Collection Diet Dietary Intervention Dietary Practices Dietary Sodium Domiciles Eating Elements Enrollment Environmental Risk Factor Fatty acid glycerol esters Flavonoids Food Food Patterns Foundations Fruit Genetic Genetic Status Geography Goals Grain Health Health Personnel Health Service Area Hypertension Illinois Individual Infrastructure Institutes Intake Intervention Investigation Kidney Diseases Knowledge Link Measures Mediating Methods Modeling Morbidity - disease rate Nutritional Nutritional Science Nutritional Study Outcome Participant Pathway interactions Patient Self-Report Physiological Plant Proteins Play Population Population Characteristics Precision Health Preventive Property Protocols documentation Public Health Race Randomized Controlled Trials Recommendation Reporting Research Research Personnel Risk Role Science Site Sodium Specific qualifier value Subgroup Techniques Technology Testing Time Universities Variant base blood pressure control blood pressure reduction blood pressure regulation cardiometabolism cardiovascular risk factor clinical center clinical research site clinical trial participant data resource dietary dietary adherence dietary constituent egg epidemiology study feeding fruits and vegetables hypertensive individual response individual variation insight inter-individual variation metabolomics microbial microbiome microbiome research modifiable risk mortality novel novel marker nutrition nutritional genomics population based population health precision medicine precision nutrition premature prevent primary outcome recruit response socioeconomics systematic review

项目摘要

PROJECT SUMMARY Epidemiological and clinical studies support an important role of nutrition in health. However, nutrition research is limited by bias due to self-reported diet data and inter- and intra-individual variation. High-throughput `omic' profiling techniques combined with advanced remote real-time data collection now enable comprehensive studies of individual responses to diet thereby creating opportunities for personalized nutrition advice. Our overall goal is to facilitate the Nutrition for Precision Health (NPH) Consortium by leveraging our existing Illinois Precision Medicine Consortium (IPMC) infrastructure to enroll All of Us Research Program (AoURP) participants in the discovery nutrition science study involving three diet modules. Proposed is investigation of specific elements of a Dietary Approaches to Stop Hypertension (DASH) diet with blood pressure (BP) as the primary outcome. BP is regulated by a complex network of mechanisms under the influence of genetic and environmental factors, and high BP is recognized as the leading modifiable risk factor for cardiovascular disease, cerebrovascular disease, kidney disease and all-cause mortality worldwide. DASH diet adherence has consistently documented reduced BP, independent of baseline calorie or sodium intake. Although older, hypertensive and Black persons show greater BP responses to DASH adherence and reduced dietary sodium intake, inter-individual variability is observed and remains unexplained. In Module 1, we will follow 2,000 AoURP participants for 14 days to examine baseline diet and physiological responses to test-meal challenges hypothesized to elicit variable physiological and metabolomic responses based on individual cardiometabolic, genetic and gut microbial status. We then examine responses to three 14-day intervention periods involving DASH-type diets among 400 consenting Module 1 participants in a free-living controlled feeding study (Module 2) and in 200 Module 1 participants in a domicile controlled feeding study (Module 3). The three intervention diets are isocaloric, sodium equivalent and include: i) DASH-Standard, ii) DASH-FFF, specifying fruits, flavonoids and fat and DASH-PP, emphasizing plant protein. Each diet has distinctive nutritive properties that influence BP regulation and each will elucidate diverse physiological, metabolomic, and microbiomic responses that are modified by cardiometabolic and genetic status. Our three IPMC clinical sites including Northwestern University, the University of Chicago, and the Illinois Institute of Technology span wide yet geographically distinct service areas in ethnically and socioeconomically diverse Chicago communities, thereby offering targeted enrollment of demographically diverse participants. This research in collaboration with the NPH consortium initiates fundamental causal and mechanistic insight into the role of the DASH-type diet in BP regulation with potential to discover novel biological pathways underlying risks for developing high BP. This advanced knowledge can inform unprecedented personalized diet recommendations to prevent and treat the massive public health burden off hypertension.

项目概要流行病学和临床研究支持营养在健康中的重要作用。然而，营养学研究受到自我报告的饮食数据以及个体间和个体内差异造成的偏差的限制。高通量“组学” 分析技术与先进的远程实时数据收集相结合，现在可以实现全面的研究个人对饮食的反应，从而为个性化营养建议创造机会。我们的总体目标是利用我们现有的技术来促进精准健康营养 (NPH) 联盟的发展伊利诺伊州精准医学联盟 (IPMC) 基础设施将参与“我们所有人研究计划”(AoURP) 涉及三个饮食模块的发现营养科学研究的参与者。建议调查以血压 (BP) 为衡量指标的降血压饮食方法 (DASH) 的具体要素主要结果。血压在遗传和遗传因素的影响下受到复杂机制网络的调节。环境因素，高血压被认为是心血管疾病的主要可改变危险因素疾病、脑血管疾病、肾脏疾病和全世界的全因死亡率。坚持 DASH 饮食一贯记录血压降低，与基线卡路里或钠摄入量无关。虽然年纪大了，高血压和黑人对坚持 DASH 和减少膳食钠表现出更大的血压反应摄入量，观察到个体间差异，但仍无法解释。在模块 1 中，我们将遵循 2,000 AoURP 参与者为期 14 天，检查基线饮食和对测试膳食挑战的生理反应假设根据个体心脏代谢引起不同的生理和代谢反应，遗传和肠道微生物状况。然后我们检查对三个 14 天干预期的反应，其中涉及在一项自由生活控制喂养研究中，400 名同意的模块 1 参与者接受了 DASH 型饮食（模块 2) 以及 200 名模块 1 参与者参加住所控制喂养研究（模块 3）。三大干预饮食为等热量、钠当量，包括：i) DASH-标准，ii) DASH-FFF，指定水果，类黄酮和脂肪以及 DASH-PP，强调植物蛋白。每种饮食都有独特的营养特性影响血压调节，每一个都将阐明不同的生理、代谢组和微生物组反应因心脏代谢和遗传状态而改变。我们的三个 IPMC 临床中心包括西北大学大学、芝加哥大学和伊利诺伊理工学院跨度广泛但地理分布广泛在种族和社会经济多元化的芝加哥社区中提供独特的服务区域，从而提供有针对性地招募不同人口的参与者。这项与 NPH 联盟合作的研究开启了基本的因果和机制洞察研究 DASH 型饮食在血压调节中的作用，并有可能发现新的生物途径发生高血压的潜在风险。这种先进的知识可以提供前所未有的个性化信息预防和治疗高血压造成的巨大公共卫生负担的饮食建议。