CACHET - IHSFC

凯切特 - IHSFC

基本信息

批准号：
10641971
负责人：
Briseis A Aschebrook-Kilfoy
金额：
$ 30.33万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10641971
关键词：
Abbreviations Address Area Arsenic Biological Biological Assay Biological Markers Biometry Cancer Center Chicago Clinic Clinical Clinical Sciences Clinical and Translational Science Awards Collaborations Collection Communities Computer software Computerized Medical Record Consent Core Facility Data Data Analyses Data Analytics Data Collection Detection Development Devices Disease Disparity Dust Early Diagnosis Enrollment Ensure Environment Environmental Exposure Environmental Health Equipment Ethics Ethnic Origin Evaluation Federally Qualified Health Center Focus Groups Food Funding Health Health Sciences Hispanic Community Health Study/Study of Latinos Human Human Resources Illinois Information Dissemination Infrastructure Institution Institutional Review Boards Knowledge Leadership Longitudinal Studies Measurement Medical Methods Minority Health Research Mission Modeling Modernization Molecular National Health and Nutrition Examination Survey Organizational Efficiency Outcome Participant Particulate Matter Personnel Recruitments Pilot Projects Population Population Heterogeneity Precision Health Prevention Principal Investigator Questionnaires Race Research Research Design Research Personnel Research Project Grants Research Training Resources Sampling Services Source Statistical Data Interpretation Statistical Methods Techniques Technology Training Translating Translational Research Universities Water Work arm biobank biomarker development clinical center cohort community engagement complex data data management design disorder prevention electronic data environmental health disparity environmental justice epidemiology study ethnic health disparity fundamental research health data health science research human biological material human tissue implementation study improved indoor air innovation member mobile application mobile computing multi-ethnic novel population based population health programs quality assurance racial health disparity recruit sample collection sensor statistical service study population surveillance study targeted biomarker tissue resource tool translational health science translational study wearable device

项目摘要

1. INTEGRATED HEALTH SCIENCES FACILITY CORE: ABSTRACT The Integrated Health Sciences Facility Core (IHSFC) will provide infrastructure and highly focused trans- disciplinary services to CACHET members including access to cohorts and bio-banking; environmental health sciences (EHS) design, implementation and translational study services; innovative approaches to population exposure estimation using both traditional and cutting-edge techniques including device, sensors and wearables and mobile app technologies; and novel statistical services with a focus on challenges in geospatial modeling and evaluation of mixtures. This array of services will provide tools to translate fundamental research into knowledge supporting disease prevention and the mitigation of racial/ethnic environmental health disparities. The IHSFC will have leadership at both University of Illinois at Chicago (UIC) and University of Chicago (UofC), and will build upon the existing research resources at these institutions to ensure that Core support is used to develop additional key resources for conducting EHS work. Many of the resources that the IHSFC uses to meet the EHS translational research needs of CACHET investigators that exist at our two institutions have been modified, enhanced, centralized and efficiently organized between the two institutions by leveraging the institution-specific strengths and growing Core resources. IHSFC personnel include experts in epidemiological study design, population and clinic-based studies, specimen collection and quality assurance, exposure technology and data analytics to support superior exposure assessment, and statistical methods relevant for modern environmental health studies. IHSFC personnel will collaborate with personnel in the Environmental Biomarkers Facility Core (EBC) to address molecular assay requirements involving biomarkers of environmental exposures and environmental signatures in human biological materials. The IHSFC will also provide interpretation of results and facilitate dissemination of the results to Chicago communities and beyond in conjunction with the Community Engagement Core (CEC). In addition, the IHSFC will work with the CEC as well as relevant Institutional CTSA and Cancer Center Cores to translate community-based EHS questions and concerns into specific scientific hypotheses that may be supported by CACHET through the Pilot Project Program (PPP). Furthermore, the IHSFC will facilitate projects that utilize the Human Health Exposure Analysis Resource (HHEAR), to further enhance CACHET opportunities to conduct expanded target and untargeted analyses of environmental relevance.

1. 综合健康科学设施核心：摘要综合健康科学设施核心（IHSFC）将提供基础设施和高度集中的跨为 CACHET 成员提供纪律服务，包括进入队列和生物银行；环境健康科学（EHS）设计、实施和转化研究服务；人口创新方法使用传统和尖端技术（包括设备、传感器和可穿戴设备）进行暴露估计和移动应用技术；和新颖的统计服务，重点关注地理空间建模中的挑战和混合物的评估。这一系列服务将提供将基础研究转化为支持疾病预防和减轻种族/民族环境健康差异的知识。 IHSFC 将由伊利诺伊大学芝加哥分校 (UIC) 和芝加哥大学 (UofC) 领导，并将利用这些机构现有的研究资源，确保核心支持用于开发额外的关键资源来开展 EHS 工作。 IHSFC 使用许多资源来满足我们两个机构存在的 CACHET 研究人员的 EHS 转化研究需求已得到满足通过利用两个机构之间的机构特定的优势和不断增长的核心资源。 IHSFC 人员包括流行病学专家研究设计、人群和临床研究、样本采集和质量保证、暴露技术和数据分析，以支持卓越的暴露评估，以及相关的统计方法现代环境健康研究。 IHSFC 人员将与环境部门的人员合作生物标志物设施核心 (EBC)，用于满足涉及环境生物标志物的分子测定要求人类生物材料的暴露和环境特征。 IHSFC 还将提供解释结果并促进将结果传播到芝加哥社区及其他地区与社区参与核心 (CEC) 结合。此外，IHSFC还将与CEC合作作为相关机构 CTSA 和癌症中心核心，翻译基于社区的 EHS 问题和对 CACHET 可能通过试点项目计划支持的具体科学假设的关注（购买力平价）。此外，IHSFC 将促进利用人类健康暴露分析资源的项目 (HHEAR)，进一步增强 CACHET 机会，以进行扩展的目标和非目标分析环境相关性。