Establishment of a SPF Rhesus Macaque Colony

SPF 恒河猴群落的建立

• 批准号: 10362396
• 负责人: Deepak Kaushal
• 金额: $ 50万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10362396
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Acute; Address; Animals; Area; Back; Breeding; COVID-19; COVID-19 pandemic; Chronic; Complex; Development; Evaluation; Functional disorder; Funding; Future; Grant; HIV; HIV Infections; HIV/TB; Heating; Housing; Infection; Institution; Investigation; Lighting; Macaca; Macaca mulatta; MicroRNAs; Modeling; Myeloid Cells; New England; Newborn Infant; Parents; Population Research; Postdoctoral Fellow; Primates; Production; Recommendation; Reporting; Research; Research Personnel; Resources; Rhesus; Role; SIV; Sales; Scheme; Scientist; Speed; United States National Institutes of Health; Vaccines; Work; building renovation; co-infection; gastrointestinal; germ free condition; improved; nanoparticle; nonhuman primate; operation; pandemic disease; primate development; programs; simian human immunodeficiency virus; stem; ventilation

U42 AR Supplement: SNPRC Proposal to expand U42 rhesus monkey holding and Production. Abstract The Southwest National Primate Research Center (SNPRC) has developed an SPF Indian-derived (ID) rhesus colony, supported by the NIH SPF rhesus breeding program (U42 OD010442). HIV/AIDS research at the center strongly supports both internal and external scientists whose work investigates critical topics including, but not limited to, Mtb/HIV coinfection, development of nanoparticle vaccines against SIV/HIV, HIV/SHIV infection in newborn rhesus monkeys, role of miRNA’s in gastrointestinal dysfunction in the HIV/SIV rhesus model, the investigation of CNS myeloid cells as chronic reservoirs in SIV-infected primates, and the development of host- directed therapies against SIV/HIV and Mtb/HIV infection. There has been a critical shortage of these primates for research for over a decade. The sudden usage of rhesus macaques for COVID-19 research—necessitated by the pandemic—has created further strain on the availability of this primate model for HIV/AIDS research [NOT- OD-20-173. September 11, 2020 ‘Notice of Limited Availability of Research Nonhuman Primates’]. In order to meet urgent needs for recent COVID-19 research, SNPRC rhesus macaques, over the past year, have been mostly directed to these studies as required by Operation Warp Speed and directives put forth from the NIH. This has severely impacted our ability to maintain research primates for our HIV/AIDS investigators under the U42 funding. There is an acute, urgent need to increase production of these U42 SPF Indian-derived primates. This application proposes to increase holding and breeding space at the SNPRC to support expansion of this colony.

U42 AR 补充：SNPRC 关于扩大 U42 恒河猴饲养和生产的提案。 抽象的 西南国家灵长类研究中心 (SNPRC) 培育出 SPF 印度源 (ID) 恒河猴 群体，由 NIH SPF 恒河猴育种计划（U42 OD010442）在该中心的艾滋病毒/艾滋病研究支持。 强烈支持内部和外部科学家，他们的工作研究关键主题，包括但不包括 仅限于 Mtb/HIV 双重感染、针对 SIV/HIV、HIV/SHIV 感染的纳米颗粒疫苗的开发 新生恒河猴，miRNA 在 HIV/SIV 恒河猴模型胃肠道功能障碍中的作用， 研究中枢神经系统骨髓细胞作为 SIV 感染灵长类动物的长期储存库，以及宿主细胞的发育 针对 SIV/HIV 和 Mtb/HIV 感染的定向疗法 这些灵长类动物严重短缺。 十多年来，突然使用恒河猴进行 COVID-19 研究是必要的。 大流行对这种用于艾滋病毒/艾滋病研究的灵长类动物模型的可用性造成了进一步的压力[不是- OD-20-173。2020 年 9 月 11 日“非人类灵长类动物研究有限的通知”]。 为了满足近期 COVID-19 研究的迫切需求，SNPRC 恒河猴在过去的一年里 主要针对曲速行动的要求和 NIH 的指令进行这些研究。 这严重影响了我们为艾滋病毒/艾滋病研究人员维持研究灵长类动物的能力 U42 资金迫切需要增加这些 U42 SPF 印度灵长类动物的产量。 该申请建议增加 SNPRC 的饲养和繁殖空间，以支持该项目的扩展 殖民地。