Baboon model of long term effects of SARS-CoV-2 infection

SARS-CoV-2 感染长期影响的狒狒模型

• 批准号: 10413419
• 负责人: Deepak Kaushal
• 金额: $ 49.97万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10413419
• 关键词: 2019-nCoV; Address; Age; Alveolar; Animals; Autopsy; Biological Assay; Blood; Brain; COVID-19; COVID-19 susceptibility; COVID-19 therapeutics; Callithrix; Callithrix jacchus jacchus; Cells; Clinical; Collaborations; Complex; Confocal Microscopy; Disease; Event; Exhibits; Flow Cytometry; Health; Heart; Histopathology; Human Resources; Image; Immune; Immunology; In Situ Hybridization; Infection; Interferon Type I; Kidney; Learning; Lesion; Liver; Long COVID; Long-Term Effects; Longitudinal Studies; Lung; Macaca; Macaca mulatta; Modeling; Morbidity - disease rate; Myeloid Cells; Nose; Oral; Organ; Papio; Pathologic; Pathology; Pneumonia; Proteins; Pulmonary Inflammation; Pulmonary Pathology; Pulmonary function tests; RNA; Reporting; Route; SARS-CoV-2 infection; SARS-CoV-2 pathogenesis; Skin; Swab; Symptoms; Therapeutic; Thoracic Radiography; Time; Tissues; Viral; Virus; Virus Diseases; Virus Replication; Washington; Widespread Disease; X-Ray Computed Tomography; base; comparative; cost; cytokine; cytokine release syndrome; experimental study; infectious disease model; inflammatory milieu; interstitial; lung imaging; nonhuman primate; pulmonary function; rectal; response; serial imaging; sex; single-cell RNA sequencing; systemic inflammatory response; transcriptome sequencing; vaccine evaluation

Abstract. Nonhuman primate (NHP) models of SARS-CoV-2 infection showed mostly mild disease. Infection of old-world origin baboons however showed moderate disease especially with significantly more lung pathology and evidence of viral dissemination to extrapulmonary tissues. Baboons are therefore an important model to study the pathogenesis of SARS-CoV-2 infection and identify therapeutic approaches to control COVID-19. We hypothesize that a study of long term effects of COVID-19 in the lung and other compartments is therefore best studied in a model like baboon. Here we propose experiments to address this issue.

抽象的。 SARS-CoV-2 感染的非人灵长类动物 (NHP) 模型大多表现出轻度疾病。旧世界的感染 然而，起源狒狒表现出中度疾病，尤其是肺部病理学明显更多， 病毒传播至肺外组织的证据。因此，狒狒是研究的重要模型 SARS-CoV-2 感染的发病机制并确定控制 COVID-19 的治疗方法。我们 因此，假设最好研究 COVID-19 对肺和其他部位的长期影响 在像狒狒这样的模型中进行研究。在这里，我们提出实验来解决这个问题。