NIAMS Multidisciplinary Clinical Research Center

NIAMS多学科临床研究中心

• 批准号: 7393161
• 负责人: EDWARD H YELIN
• 金额: $ 105.07万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-20 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7393161
• 关键词: NIAMS; Multidisciplinary; Clinical; Research; Center

DESCRIPTION (provided by applicant): The broad aim of the proposed UCSF Multidisciplinary Clinical Research Center Program (UCSF MCRC) is to improve outcomes for persons with various forms of rheumatic diseases by discovery of the medical, demographic, and contextual factors affecting those outcomes. This overarching aim is pursued by a comprehensive program of clinical research in the rheumatic diseases, including but not limited to that within the MCRC; by serving as a catalyst for such clinical research throughout UCSF; and by systematic training of clinical investigators in the rheumatic diseases. The MCRC consists of an Administrative Unit, Methodology Core, three five-year projects, and a three-year Development and Feasibility (D&F) Study. The participants in the MCRC span three UCSF schools (Medicine, Nursing, and Dentistry) and UC Davis and include representatives of nine discrete academic units, including the UCSF GCRC. The Center's Director and Associate Director are Drs. Edward Yelin and Lindsey Criswell, respectively. The Director of the Core Unit is Dr. Patricia Katz. The activities of the MCRC are guided on a day-to-day basis by an Executive Committee. Strategic oversight of the Center is provided by Internal (UCSF) and External Advisory Committees. The research in the MCRC is based on analysis of primary data on persons with two specific diseases, Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA), and on analysis of secondary data on persons with a broader array of musculoskeletal conditions. The specific five-year projects are: "The Interplay of Sociodemographic and Genetic Factors in SLE Health Disparities"; "SLE and Employment: The Impact of Individual and Contextual Factors"; and, "Do Mid-Life Musculoskeletal Conditions Lead to Disability in the Elderly?". The D&F study is: Neuropsychiatric Symptoms and MRI Markers in SLE Patients APLA".

描述（由申请人提供）：拟议的UCSF多学科临床研究中心计划（UCSF MCRC）的广泛目的是通过发现医疗，人口统计学和情境因素来改善各种形式的风湿性疾病的人的结果，从而改善影响这些结果的医疗，人口统计学和情境因素。这一总体目的是通过风湿性疾病的临床研究综合计划来追求的，包括但不限于MCRC中的临床疾病；通过作为整个UCSF进行此类临床研究的催化剂；以及系统的临床研究人员在风湿病中的培训。 MCRC由一个行政部门，方法论核心，三个五年项目以及三年的发展和可行性（D＆F）研究组成。 MCRC的参与者跨越了UCSF学校（医学，护理和牙科）和UC Davis，并包括包括UCSF GCRC在内的九个离散学术单位的代表。该中心的董事兼副主任是Drs。爱德华·耶林（Edward Yelin）和林赛·克里斯威尔（Lindsey Criswell）。核心部门的主任是帕特里夏·卡兹（Patricia Katz）博士。 MCRC的活动由执行委员会日常指导。该中心的战略监督由内部（UCSF）和外部咨询委员会提供。 MCRC中的研究基于对患有两种特定疾病的人，全身性红斑狼疮（SLE）和类风湿关节炎（RA）的主要数据的分析，以及分析具有更广泛肌肉骨骼疾病的人的二级数据。特定的五年项目是：“ SLE健康差异中社会人口统计学和遗传因素的相互作用”； “ SLE和就业：个人和背景因素的影响”；而且，“中年肌肉骨骼状况会导致老年人的残疾吗？”。 D＆F研究是：SLE患者APLA的神经精神症状和MRI标记”。