NIAMS Multidisciplinary Clinical Research Center

NIAMS多学科临床研究中心

• 批准号: 8704206
• 负责人: JOANNE M. JORDAN
• 金额: $ 110.35万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-19 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8704206
• 关键词: Address; Adoption; African American; Arthritis; Biological; Biological Markers; Biomechanics; Chronic Disease; Clinical Research; Cohort Studies; Collaborations; Communities; County; Data; Degenerative polyarthritis; Development; Education; Face; Fostering; Foundations; Future; Goals; Health; Health Care Costs; Injury; Institute of Medicine (U.S.); Intervention; Knee Injuries; Life; Maintenance; Measurement; Mediating; Mentors; Methodology; Military Personnel; Mission; National Institute of Arthritis and Musculoskeletal and Skin Diseases; North Carolina; Outcome; Physical activity; Public Health; Recommendation; Reporting; Research; Research Methodology; Research Personnel; Research Training; Role; Self Management; Specimen; Training; Universities; Weight maintenance regimen; Woman; cohort; disability; injury prevention; innovation; joint injury; men; multidisciplinary; next generation; novel; prevent; prospective

DESCRIPTION (provided by applicant): Responding to an urgent call to action from the 2012 Institute of Medicine report. Living Well with Chronic Illness: A call for public health action and the 2010 National Public Health Agenda for Osteoarthritis (NPHAOA), this application proposes a new Multidisciplinary Clinical Research Center (MCRC) at the Thurston Arthritis Research Center (TARC) at the University of North Carolina (UNC), entitled Mitigating The Public Health Impact of OA. The proposed MCRC draws together multiple units and investigators new to OA research into novel collaborative relationships with the long-term goals of: 1) understanding the etiologic factors associated with development and progression of OA and Its resultant disability; 2) Identifying best practices to Inform adoption of critical public health recommendations in communities to prevent the occurrence and progression of these outcomes, and 3) transforming the face of OA research on the UNC campus by serving as a hub for Innovation, training, and collaboration. The NPHAOA recommends addressing joint injury prevention, increased physical activity, weight control, and arthritis self-management education to slow this looming public health crisis. This MCRC will use these themes as its focus and leverages 2 distinctive UNC studies: 1) the Johnston County OA Project, a 20+ year prospective cohort of OA and disability in African American and White men and women in NC, and 2) JUMP-ACL, a unique cohort studying knee injury in men and women military cadets in whom pre-injury biomechanics data and biological specimens are available. Project #1 addresses basic mechanisms behind the role of partner support in the initiation and maintenance of increased physical activity in insufficienty active people with OA. Project #2 examines the relationship between biomechanics and biomarkers in predicting knee injury and development of injury-mediated OA. The Methodology Core is central and will support the 2 proposed projects and multiple other extant projects relevant to the mission of NIAMS and will foster new research and provide training in research methodology and mentoring to the next generation of arthritis researchers. An Administrative Core with an Executive Committee and Internal and External Advisory Boards will support the Center. By bringing together our established investigators with new expertise in physical activity measurement, biomechanics, and biomarkers, and newly trained young investigators, this vibrant center will advance the public health OA agenda and lay the foundation for implementing future interventions to treat and prevent OA and its consequences.

描述（由申请人提供）：回应2012年医学研究所报告的紧急行动呼吁。患有慢性疾病：呼吁采取公共卫生行动和 该申请是2010年国家公共卫生骨关节炎议程（NPHAOA），提议在北卡罗来纳大学瑟斯顿关节炎研究中心（TARC）的新的多学科临床研究中心（MCRC）（UNC）（UNC），有资格减弱OA的公共卫生影响。拟议的MCRC将多个单位和研究人员汇总为OA研究的新型合作关系，与以下长期目标：1）了解与OA的发展和发展相关的病因学因素及其由此导致的残疾； 2）确定最佳实践，以告知在社区中采用关键公共卫生建议，以防止这些结果的发生和发展，3）通过作为创新，培训和协作的枢纽，在UNC校园中转变OA研究的面貌。 NPHAOA建议解决预防联合伤害，增加体育锻炼，体重控制和关节炎自我管理教育，以减缓这一迫在眉睫的公共卫生危机。该MCRC将使用这些主题作为重点和利用2个独特的UNC研究：1）约翰斯顿县OA项目，非裔美国人的OA和残疾人的前瞻性群体和北卡罗来纳州的白人男性和女性，以及2）Jump-ACL，一个独特的队列，在男性和工业生物学上研究男性和妇女的膝关节受伤，可生物机能学指定性数据和生物学数据。项目＃1解决了合作伙伴支持在启动和维护OA不足的运动中增加体育锻炼中的作用背后的基本机制。项目2研究了生物力学与生物标志物之间在预测膝关节损伤和损伤介导的OA发展方面的关系。该方法核心是中心的，将支持与NIAMS的使命相关的两个拟议项目和其他现有的项目，并将促进新的研究，并为下一代关节炎研究人员提供研究方法和指导的培训。执行委员会以及内部和外部咨询委员会的行政核心将支持该中心。通过将我们知名的研究人员汇集在一起​​，具有新的体育锻炼专业知识 这个充满活力的中心将提高OA公共卫生议程，并为实施未来的干预措施奠定基础，以治疗和预防OA及其后果。