The Johnston County OA Project: Arthritis and Disability

约翰斯顿县 OA 项目：关节炎和残疾

• 批准号: 8235232
• 负责人: JOANNE M. JORDAN
• 金额: $ 65万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8235232
• 关键词: Johnston; County; OA; Project; Arthritis; Johnston; County; OA; Project; Arthritis

DESCRIPTION (provided by applicant): Abstract In accordance with RFA-DP11-005, this study will provide long-term outcome data for the prevalence, incidence and progression of radiographic knee and hip OA, knee and hip symptoms, and disability in African Americans and Whites, aged 45 years and older. It will additionally examine the occurrence and timing of concomitant obesity, diabetes mellitus, and cardiovascular disease, and their interactive effects, upon OA outcomes, and extend the timeline for examination of risk (leg length inequality) and potentially protective factors (weight maintenance) upon these outcomes. This proposal requests process and technical support to complete the 3rd follow-up (T3) of the Johnston County Osteoarthritis Project, an average of 4 - 7 years after the 2nd 5-year follow-up (T2), approximately 10 - 15 years after the 1st follow-up, and 20-25 years after the baseline examination (T0). The effect of some risk factors may take longer time periods to exert their effects than are commonly observed in most OA studies. This study with its long follow-up time is poised to fill that knowledge gap. This study of risk factors for incidence and progression of these outcomes in AAs and Whites in a rural, Southern county has included extensive radiographic, clinical, interview, and functional data on over 4,300 individuals (approximately 1/3 African American, 40% men) throughout these past 20 years. The current sample eligible for T3 includes individuals from the original T0 baseline time point as well as individuals from 2 cohort enrichments conducted in 2003-2004 and ongoing in 2011-12. The protocol and data collection instruments for T3 are now in development, and will be available and approved by the time this grant, if successful, is funded. All individuals will complete radiographic examinations of the knees, hips, patellofemoral joints, hands, and lumbar spine, physical and functional examination, extensive interviews, and DEXA, and contribute urine and blood for storage of serum, plasma, DNA and RNA. Stratified analysis and multiple logistic and polytomous logistic regression, and time-to-event analyses, with generalized estimating equations when appropriate, will be used to assess ethnic differences in the roles of risk factors assessed at T0, T1, and T2, and their timing, in the incidence and progression of the above outcomes at T3. The proposed study will thus define objectively the burden of knee and hip OA in these groups over time, increase knowledge about factors associated with the incidence and progression of OA of these joints, identify potentially modifiable risk factors for these outcomes, and identify high risk subgroups. By examining these factors in multiple aspects of the OA process in both ethnic groups within one study, efficiency and significant impact upon the public health can be maximized.

描述（由申请人提供）：根据RFA-DP11-005摘要，本研究将提供长期的结果数据，以了解射线照相膝关节的患病率，发病率和进展，膝盖和髋关节，膝盖和髋关节症状，以及45岁及以上的非裔美国人和白人的残疾。它将进一步研究伴随肥胖症，糖尿病和心血管疾病的发生和时机，及其对OA结果的互动效应，并延长了对这些表现结果的风险（腿长不平等）和潜在保护因素（腿部长度不平等）和潜在保护因素（体重维持）的时间表。该提案请求过程和技术支持，以完成约翰斯顿县骨关节炎项目的第三次随访（T3），平均在第2五年随访（T2）后4-7年，大约是在第1次随访后10-15年，以及基线检查后20-25年（T0）。某些危险因素的影响可能需要更长的时间段来发挥其作用，而不是大多数OA研究中通常观察到的效果。这项长期随访时间的研究有望填补这一知识差距。这项研究在南部县的AAS和白人中，这些结果的发生率和进展的危险因素包括有关过去20年中4,300多名个人（约1/3个非裔美国人，40％的男性）的广泛的放射线照相，临床，访谈和功能数据。符合T3的当前样本包括来自原始T0基线时间点的个体以及2003 - 2004年进行的2个队列富集的个体以及2011 - 12年度的持续时间。 T3的协议和数据收集工具现已开发，如果成功的话，将在本赠款（如果成功）的情况下获得并批准。所有个体都将完成膝盖，臀部，pat骨关节，手和腰椎的射线照相检查，身体和功能检查，广泛的访谈以及DEXA，并为血清，血浆，DNA和RNA的存储供应尿液和血液。分层分析以及多种逻辑和多型逻辑回归以及事件时间分析，并在适当的情况下进行广义估计方程式，用于评估在T0，T1和T2评估的风险因素的作用中的种族差异，及其时间及其时间，在T3处的上述结果的发生率和进展。因此，拟议的研究将随着时间的流逝而客观地定义膝关节和髋关节OA的负担，增加有关与这些关节的发生率和进展相关的因素的知识，确定这些结果的潜在可修改风险因素，并识别高风险亚组。通过在一项研究中，在两个种族中的OA过程的多个方面检查这些因素，可以最大程度地提高效率和对公共卫生的重大影响。