Midcareer Development Award in Neuroaging and Geriatric Pharmacoepidemiology Research

神经衰老和老年药物流行病学研究职业中期发展奖

基本信息

批准号：
10351611
负责人：
Allison Willis
金额：
$ 16.32万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10351611
关键词：
Address Advisory Committees Affect Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Anti-Cholinergics Award Basic Science Biological Biometry Caliber Caring Chronic Clinical Coupled Data Analyses Data Collection Data Set Dementia Dementia with Lewy Bodies Development Discipline Disease Drug Exposure Drug Interactions Drug Prescriptions Educational Background Elderly Electronic Health Record Environment Epidemiology Epilepsy Evaluation Event Exposure to Funding Geriatrics Goals Guidelines Health Health Disparities Research Health Services Health Services Research Health system Huntington Disease Impaired cognition Individual Informatics Infrastructure Intellectual functioning disability International Investigation Knowledge Learning Lewy Body Dementia Link Medical Medicare claim Mentors Mentorship Methodology Mid-Career Clinical Scientist Award (K24)Minority Modeling Monitor Motor Multiple Sclerosis Neighborhoods Neurologic Neurologic Dysfunctions Neurologist Neurology Observational Study Outcome Parkinson Disease Parkinson&apos s Dementia Patients Pennsylvania Pharmaceutical Preparations Pharmacoepidemiology Pharmacology Pharmacotherapy Population Process Psychiatry Public Health Quality of Care Reporting Research Research Design Research Infrastructure Research Methodology Research Personnel Research Training Risk Role Safety Sampling System Time Training Training Programs Traumatic Brain Injury Treatment outcome Universities analytic epidemiology care delivery care outcomes career chronic neurologic disease clinical care clinical practice cognitive function collaborative environment dementia risk design drug development epidemiology study evidence base health care disparity health care service utilization health disparity health equity health service use high risk improved innovation insight medical specialties mild cognitive impairment mixed dementia multidisciplinary neighborhood disadvantage nervous system disorder next generation novel patient oriented patient oriented research programs prospective recruit research and development social factors success treatment adherence

项目摘要

Dr. Willis is a neurologist, neuroepidemiologist, and health services researcher who has established a nationally- and internationally- recognized, independently funded research program committed to patient-oriented research focused on drug effects, care process and outcome disparities, and health service use in older adults with neurological disease. She has a successful record in mentoring trainees who approach POR from multiple educational backgrounds. Proposal aims: (1) to conduct analytical epidemiology research examining the impact of prescribing practices, drug exposures, drug-drug and drug-disease interactions on clinical, patient-reported and health care utilization outcomes in older adults, particularly those with Parkinson Disease + Dementia; Dementia with Lewy Bodies (which together comprise Lewy Body Dementia, an Alzheimer’s Disease Related Dementia/ADRD), Alzheimer’s disease (AD), Mild cognitive impairment and chronic neurological disease; (2) to conduct health disparities and health services research in older adults with neurological disease, particularly those with the above ADRDs and AD, to gain actionable insights into systematic barriers to equal care; (3a) to develop new studies at the intersection of aging, neurology, and pharmacoepidemiology focused on the biological, clinical, and qualitative effects of deprescribing and safety-guided CNS drug prescribing on cognitive function and cognitive decline in individuals with the above ADRDs, AD, and MCI; (3b) to develop new studies at the intersection of aging, disparities, and health services research, focused on describing and decomposing the relative contributions of individual, neighborhood, and social factors on disparities in guideline adherent treatment initiation, escalation, and monitoring; treatment adherence and outcomes in older adults with neurological disease, including ADRDs and AD; (4) to use Dr. Willis’s research program to train and mentor new investigators in research methods that will improve health care outcomes for older adults with ADRDs, AD and chronic neurological disorders through neuroprotective prescribing, more effective and equitable care delivery. A K24 award will provide Dr. Willis with the protected time needed to develop new research focused on neuroprotective prescribing and health disparities, generate knowledge on the drivers and effects of medical care and drug therapies for neurological disorders. A K24 will also allow Dr. Willis to increase her mentoring expertise and develop a formal mentoring program for engaging young investigators drawn from neurology, epidemiology, geriatrics, psychiatry, pharmacology, informatics, and biostatistics. Dr. Willis’s mentoring program will (1) provide mentees with direct exposure to primary data collection and secondary data analysis (2) create an interdisciplinary environment where trainees from a range of specialties will learn directly from each other (3) provide mentees with individualized research and career mentoring from her. The outstanding institutional environment and the K24 Advisory Team Dr. Willis has assembled to monitor and guide her progress at the University of Pennsylvania support the success of this proposal.

Willis 博士是一位神经学家、神经流行病学家和卫生服务研究员，他建立了一个国内和国际认可的、独立资助的研究项目，致力于以患者为导向的研究，重点关注药物作用、护理过程和结果差异以及卫生服务的使用她在指导来自多种教育背景的 POR 学员方面拥有成功的记录。提案的目的是：(1) 进行分析流行病学研究，检查处方实践、药物暴露、药物药物的影响。以及药物与疾病之间的相互作用对老年人的临床、患者报告和医疗保健利用结果的影响，特别是患有帕金森病+痴呆的老年人；路易体痴呆（共同包括路易体痴呆，一种阿尔茨海默氏病相关痴呆/ADRD）、阿尔茨海默病(AD)、轻度认知障碍和慢性神经系统疾病；(2) 对患有神经系统疾病的老年人，特别是患有上述 ADRD 和 AD 的老年人进行健康差异和卫生服务研究，以获得可行的见解探究平等护理的系统性障碍；(3a) 在衰老、神经病学和药物流行病学的交叉领域开展新的研究，重点关注停用和安全指导的中枢神经系统药物处方对认知功能和认知衰退的生物学、临床和定性影响。具有上述 ADRD、AD 和 MCI 的个体；(3b) 在老龄化、差异和健康服务研究的交叉领域开展新的研究，重点是描述和分解个人、社区和社会因素对健康服务的相对贡献。患有神经系统疾病（包括 ADRD 和 AD）的老年人在遵循指南的治疗开始、升级和监测方面存在差异；(4) 利用 Willis 博士的研究计划来培训和指导新的研究人员，以改进研究方法通过神经保护处方、更有效和公平的护理服务，为患有 ADRD、AD 和慢性神经系统疾病的老年人提供医疗保健成果，K24 奖将为 Willis 博士提供开发专注于神经保护处方的新研究所需的受保护时间。和健康差异，产生关于神经系统疾病的医疗护理和药物治疗的驱动因素和影响的知识，A K24 还将帮助 Willis 博士提高她的指导专业知识，并制定一个正式的指导计划，吸引来自神经病学、流行病学、威利斯博士的指导计划将（1）为学员提供直接接触初级数据收集和二级数据分析的机会（2）创建一个跨学科的领域。来自不同专业的学员可以直接相互学习的环境 (3) 为学员提供个性化的研究和职业指导。 Willis 博士组建了出色的机构环境和 K24 咨询团队来监控和指导她的进步。宾夕法尼亚大学支持这一提案的成功。