Characterizing the Impact of Auditory Experience on Language, Cognitive, and Neural Development in Children

表征听觉体验对儿童语言、认知和神经发展的影响

• 批准号: 10346728
• 负责人: Elizabeth Heinrichs-Graham
• 金额: $ 26.07万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10346728
• 关键词: 14 year old; Affect; Area; Attention; Auditory; Behavior; Behavioral; Brain; Child; Childhood; Clinical; Cochlear Implants; Cognition; Cognitive; Cognitive deficits; Complex; Data; Development; Dorsal; Dose; Enrollment; Exhibits; Goals; Hearing; Hearing Aids; Hearing Tests; Heterogeneity; Improve Access; Individual Differences; Intervention; Investigation; Language; Language Delays; Language Development; Language Tests; Learning; Link; Magnetic Resonance Imaging; Magnetoencephalography; Matched Group; Measures; Mediating; Memory; Methods; Multimodal Imaging; Neurons; Neurophysiology - biologic function; Neuropsychological Tests; Outcome; Parietal; Pattern; Performance; Physiological; Physiology; Plant Roots; Population; Research Project Grants; Risk; Severities; Short-Term Memory; Speech; Therapeutic; Time; Work; age related; behavior test; behavioral outcome; brain health; cognitive ability; cognitive control; cognitive development; cognitive function; cognitive performance; cognitive skill; cognitive task; cognitive testing; cohort; comparison group; dosage; executive function; experience; falls; hard of hearing; hearing impairment; imaging approach; indexing; innovation; language processing; multimodality; neurodevelopment; neuroimaging; neuromechanism; neurophysiology; normal hearing; peer; relating to nervous system; response

Project Summary/Abstract: Research Project (3) Characterizing the Impact of Auditory Experience on Language, Cognitive, and Neural Development in Children It is well-established that children with hearing loss are at risk for language and academic deficits. Hearing loss is also known to impact cognitive measures such as working memory, and language ability positively correlates with these higher-order cognitive skills. However, delays in children with hearing loss are not universal; some fall significantly behind children with normal hearing (CNH), while others perform similarly to CNH. Recent work in children with mild-to-severe hearing loss (i.e., children who are hard-of-hearing (CHH)) who wear hearing aids (HAs) suggests that the severity of language delays correlates with auditory dosage, an index of auditory experience defined by HA audibility, or the degree to which a HA improves access to speech, and the amount of HA use. Taken together, language, cognitive function, and auditory experience appear to be tightly linked, and a combination of these factors likely explains much of the variability in outcomes in CHH. However, there is currently no overall framework that captures these relationships. It is difficult to probe the interactions between language and cognition using behavioral tests, as they rely on end-point metrics and cannot evaluate cognitive processing in real-time; thus, an investigation of the central neural mechanisms is crucial. The proposed project will provide pivotal new data on the impact of auditory experience on cognitive, language, and neural function in children. Our groundbreaking preliminary work has shown altered neural dynamics during higher-order cognitive processing in CHH relative to CNH, and that these neural aberrations are significantly linked with the amount of HA use and language ability. In the current study, we will probe the interactions between auditory experience, language, and cognition using an innovative multimodal approach. Specifically, we will enroll a large cohort of CHH and demographically matched CNH and all will undergo magnetoencephalographic imaging during verbal and nonverbal cognitive tasks, structural MRI, and a battery of neuropsychological and audiometric tests. In Aim 1, we will identify differences in behavior and neurophysiology during verbal and nonverbal cognition in CHH and CNH. We posit that CHH will exhibit altered neural activity in fronto-parietal language regions during verbal cognitive tasks, while executive function and memory networks will be atypical during nonverbal cognitive tasks. In Aim 2, we will determine which neural markers of higher-order cognitive processing predict language ability, and how the relationships between language and neural function are altered in CHH. We hypothesize that neural activity during nonverbal cognition will predict language function above and beyond neural markers of verbal cognitive processing. In Aim 3, we will clarify the impact of auditory dosage on language, cognitive, and neural function in CHH. We posit that auditory dosage will mediate the relationships between behavioral outcomes and neural dynamics in CHH. This study will provide direct physiological evidence linking language development and higher-order cognition in the context of hearing loss, which will lead to better-informed, individualized therapeutic approaches for CHH.

项目摘要/摘要：研究项目 (3) 表征听觉体验的影响 儿童语言、认知和神经发展 众所周知，听力损失的儿童面临语言和学业缺陷的风险。听力损失 众所周知，它还会影响工作记忆等认知指标，并且与语言能力呈正相关 具有这些高阶认知技能。然而，听力损失儿童的延迟现象并不普遍；一些 明显落后于听力正常的儿童 (CNH)，而其他人的表现与 CNH 相似。最近的工作 佩戴助听器的轻度至重度听力损失儿童（即听力困难儿童 (CHH)） （HAs）表明语言延迟的严重程度与听觉剂量相关，听觉剂量是听觉指数 由 HA 可听度定义的体验，或 HA 改善讲话机会的程度，以及数量 HA 使用情况。总而言之，语言、认知功能和听觉体验似乎是紧密相连的，并且 这些因素的结合可能解释了 CHH 结局的大部分变异性。然而，有 目前还没有捕获这些关系的总体框架。探究之间的相互作用是困难的 使用行为测试来评估语言和认知，因为它们依赖于终点指标并且无法评估认知 实时处理；因此，对中枢神经机制的研究至关重要。拟议项目 将提供有关听觉体验对认知、语言和神经功能影响的关键新数据 孩子们。我们开创性的初步工作表明，在高阶认知过程中神经动力学发生了改变 CHH 相对于 CNH 的处理，并且这些神经畸变与 HA 使用和语言能力。在当前的研究中，我们将探讨听觉体验之间的相互作用， 使用创新的多模式方法来提高语言和认知能力。具体来说，我们将招募一大批 CHH 和人口统计匹配的 CNH 以及所有人都将在言语过程中接受脑磁图成像 和非语言认知任务、结构磁共振成像以及一系列神经心理学和听力测试。瞄准 1，我们将识别 CHH 和非语言认知过程中行为和神经生理学的差异 离岸人民币。我们假设 CHH 在言语过程中会表现出额顶叶语言区域神经活动的改变。 认知任务中，执行功能和记忆网络在非语言认知任务中将是非典型的。 在目标 2 中，我们将确定哪些高阶认知处理的神经标记可以预测语言能力， 以及 CHH 中语言与神经功能之间的关系如何改变。我们假设神经 非语言认知过程中的活动将预测超越语言神经标记的语言功能 认知处理。在目标 3 中，我们将阐明听觉剂量对语言、认知和神经的影响 CHH 中的功能。我们假设听觉剂量将调节行为结果和 CHH 中的神经动力学。这项研究将提供直接的生理学证据，将语言发展与 听力损失背景下的高阶认知，这将带来更明智、个性化的治疗 CHH 的方法。