Spatiotemporal Dynamics of Language Processing in School-Age Children with Mild-to-Severe Hearing Loss

轻度至重度听力损失学龄儿童语言处理的时空动态

• 批准号: 10652918
• 负责人: Elizabeth Heinrichs-Graham
• 金额: $ 20.26万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652918
• 关键词: Adult; Affect; Auditory; Automobile Driving; Awareness; Behavioral; Brain; Child; Clinical; Code; Cognition; Cognitive; Communication; Complex; Coupled; Data; Development; Disadvantaged; Education; Enrollment; Exhibits; Functional Imaging; Goals; Hearing Aids; Hearing Tests; Individual; Inferior; Inferior frontal gyrus; Intervention; Investigation; Knowledge; Language; Language Delays; Language Development; Language Disorders; Left; Longevity; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Mediating; Methods; Morphology; Motor Cortex; Multimodal Imaging; Nature; Neurons; Neuropsychological Tests; Neuropsychology; Noise; Outcome; Participant; Performance; Research; Risk; Role; School-Age Population; Semantics; Series; Speech; Speech Perception; Structure; Structure of supramarginal gyrus; Task Performances; Therapeutic Intervention; Vocabulary; Vocation; Work; Youth; auditory processing; behavior prediction; behavior test; career; cohort; dosage; falls; hard of hearing; hearing impairment; imaging approach; imaging study; innovation; language impairment; language processing; multimodal neuroimaging; multimodality; neural; neural network; neural patterning; neurodevelopment; neuromechanism; neurophysiology; non-invasive imaging; normal hearing; phonology; precision medicine; recruit; semantic processing; skills; spatiotemporal; structural imaging

Project Summary/Abstract Children with hearing loss are at risk for significant language delays, which cascade into difficulties in educational and vocational settings throughout the lifespan. However, language delays in children with hearing loss are not universal; some children fall significantly behind children with normal hearing (CNH), while others perform similarly to CNH. Recent work in children with mild-to-severe hearing loss (i.e., children who are hard-of-hearing [CHH]) who wear hearing aids suggests that the degree of language impairment correlates with auditory dosage, defined by both the degree to which a hearing aid provides access to speech and the amount of hearing aid use. Nonetheless, the relationship between auditory access (i.e., hearing loss and auditory dosage) and language function is still unclear. Further, the impact of auditory access on language-related neural oscillatory dynamics is completely unknown. The proposed early-career R21 project will provide pivotal new data on the impact of variability in auditory access on multiple tiers of language function and neuronal dynamics in school-age children. Our promising preliminary work shows that noninvasive imaging with magnetoencephalography (MEG) can precisely detect the neural patterns supporting language processing throughout the left-lateralized language network in children and can quantify the relationship between altered neuronal activity and auditory dosage in CHH. In the current study, we will characterize the associations between auditory access, language processing, and neural development in a large cohort of CHH and demographically matched CNH. Participants will undergo task-based MEG during a battery of language tasks, structural MRI, and neuropsychological and audiometric testing. In Aim 1, we will identify the spatiotemporal oscillatory dynamics that underlie the behavioral differences in language processing observed between CHH and demographically matched CNH. Deficits in language processing in CHH will be coupled with increased task-related neural activity and altered functional connectivity throughout the left-lateralized language network. CHH will also recruit homologous language-related regions in the right hemisphere, indicative of a compensatory mechanism, and network-level oscillatory aberrations will predict task performance. In Aim 2, we will characterize the impact of auditory dosage on language processing performance and neurophysiology. We hypothesize that CHH with higher auditory dosage will exhibit better performance in language tasks and more normalized language-related neural activity. Further, we hypothesize that the individual contributions of hearing aid use and fit will depend on the degree of hearing loss, such that hearing aid use will have a greater effect on children with milder hearing loss, while hearing aid audibility will be the more significant factor in children with more severe hearing loss. This study will provide precise, quantitative markers supporting key facets of language development and will identify the individual and additive contributions of malleable auditory factors such as hearing aid fit and use. These data will help characterize the nature of language impairments in CHH and be used to optimize therapeutic interventions.

项目概要/摘要 听力损失儿童面临严重语言发育迟缓的风险，从而导致教育困难 和整个生命周期的职业环境。然而，听力损失儿童的语言发育迟缓并不 普遍的;有些孩子明显落后于听力正常的孩子 (CNH)，而另一些孩子则表现不佳 与CNH类似。最近针对轻度至重度听力损失儿童（即听力困难的儿童）的工作 [CHH]）佩戴助听器的人表明语言障碍的程度与听觉剂量相关， 由助听器提供言语的程度和助听器的使用量来定义。 尽管如此，听觉通路（即听力损失和听觉剂量）与语言之间的关系 功能还不清楚。此外，听觉访问对语言相关神经振荡动力学的影响 完全未知。拟议的早期职业 R21 项目将提供有关影响的关键新数据 学龄儿童的多层次语言功能和神经元动态的听觉通路的变异性。 我们充满希望的初步工作表明，脑磁图 (MEG) 无创成像可以 精确检测支持整个左脑语言处理的神经模式 儿童网络，可以量化神经元活动改变与听觉剂量之间的关系 CHH。在当前的研究中，我们将描述听觉访问、语言处理、 以及一大群 CHH 和人口统计学上匹配的 CNH 的神经发育。参与者将经历 在一系列语言任务、结构 MRI 以及神经心理学和听力测量中进行基于任务的 MEG 测试。在目标 1 中，我们将确定行为差异背后的时空振荡动力学 在 CHH 和人口统计匹配的 CNH 之间观察到的语言处理过程。语言缺陷 CHH 中的处理将与任务相关的神经活动增加和功能连接改变相结合 整个左偏语言网络。 CHH还将招募同源语言相关区域 右半球，表明补偿机制和网络级振荡畸变将 预测任务绩效。在目标 2 中，我们将描述听觉剂量对语言处理的影响 表现和神经生理学。我们假设听觉剂量较高的 CHH 会表现得更好 语言任务的表现和更规范的语言相关神经活动。进一步，我们假设 助听器使用和适配的个人影响将取决于听力损失的程度，例如 助听器的使用对听力损失较轻的儿童影响更大，而助听器的听力会下降 听力损失更严重的儿童中更重要的因素。这项研究将提供精确、定量的 支持语言发展关键方面的标记，并将确定个人和附加贡献 可塑性听觉因素的影响，例如助听器的适配和使用。这些数据将有助于表征 CHH 的语言障碍并可用于优化治疗干预措施。