Senior Research Career Scientist

高级研究职业科学家

基本信息

批准号：
10315818
负责人：
RONALD J TRIOLO
金额：
--
依托单位：
LOUIS STOKES CLEVELAND VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-10-01 至 2028-09-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10315818
关键词：
Achievement Acute Address Adopted Affect American Amputation Amputees Animals Ankle Architecture Archives Area Award Biomechanics Biomedical Engineering Book Chapters Chronic Chronic Disease Clinical Communities Community Participation Contracts Development Devices Diabetes Mellitus Disabled Persons Education Electrodes Employee Environment Equilibrium Esthesia Etiology Exercise Exhibits Fall prevention Fatigue Floor Funding Gait Gait abnormality Health Healthcare Heart Hospital Costs Human Impairment Implant Individual Injury Institutes Intervention Intuition Joints Journals Knee Laboratory Study Lead Legal patent Leisure Activities Life Style Limb Prosthesis Limb structure Location Lower Extremity Lung Malignant Neoplasms Manual wheelchair Manufacturer Name Mechanics Mechanoreceptors Mediation Medical Medical Device Medical Students Medical center Medicine Mentors Methods Modality Motion Motor Movement Multi-Institutional Clinical Trial Multiple Sclerosis Muscle Muscle Contraction Musculoskeletal Equilibrium Names Nerve Neuraxis Neuromechanics Neuromuscular Diseases Neurons Operative Surgical Procedures Output Paper Paralysed Participant Peer Review Pelvis Perception Performance Peripheral Peripheral Nerves Personal Satisfaction Phase Physical Medicine Physical Rehabilitation Population Postdoctoral Fellow Posture Preclinical Testing Principal Investigator Process Psychophysics Publications Ramp Reaction Recurrence Rehabilitation therapy Reporting Research Research Personnel Risk Safety Scientist Self-Help Devices Seminal Sensory Series Services Site Skin Social isolation Spinal Cord Spinal cord injury Stroke System Techniques Technology Textbooks Tissues Translations Trauma United States Department of Veterans Affairs United States National Institutes of Health Universities Vertebral column Veterans Veterans Health Administration Visual Volition Walking Wheelchair propulsion Wheelchairs Work body system bone career clinical application clinical translation computerized tools cost design design verification diabetic disability exercise intervention exoskeleton experience fall injury falls feasibility trial first-in-human foot functional independence graduate student improved improved mobility innovation limb loss neural implant neural prosthesis neural stimulation neuroprosthesis novel prevent programs rehabilitation research relating to nervous system research and development residual limb sciatic nerve sedentary lifestyle senior faculty social spine bone structure surgery outcome translational framework unhealthy lifestyle walking speed

项目摘要

Dr. Ronald J. Triolo is Senior Research Career Scientist with the Rehabilitation R&D Service, and a Tenured Full Professor of Biomedical Engineering at Case Western Reserve University. He is Executive Director of the VA RR&D Center for Advanced Platform Technology which develops novel medical devices and assistive restorative technologies for individuals with sensorimotor impairments or limb loss. Dr. Triolo has authored over 150 peer-reviewed publications and textbook chapters, and has mentored more than 40 graduate and medical students or post-doctoral trainees. He currently leads independent research programs funded the VA, NIH, DoD and other agencies as Principal or Co-Principal Investigator. Dr. Triolo was inducted into the American Institute for Medical and Biological Engineering, received the Paul B. Magnuson Award for outstanding achievement in Rehabilitation Research and Development from the VA, and was named the Outstanding Veterans Health Administration Employee (Honorable Mention) of 2020 by the Disabled American Veterans (DAV). Dr. Triolo has devised, patented and evaluated assistive devices to facilitate the sit-to-stand transition and negotiate stairs, ramps or other architectural barriers, and is in the process of preparing novel interventions for exercising after spinal cord injury (SCI) for dissemination within the VHA. His research program encompasses five main areas: 1. Implanted Neuroprostheses for Standing and Walking: Dr. Triolo leads an interdisciplinary team dedicated to developing, deploying, and evaluating the clinical outcomes of surgically implanted motor system neuroprostheses for lower extremity function after SCI. He quantifies their acute and chronic performances, and explores novel methods of integrating stimulated and volitional muscle activity. His team creates new computational tools to analyze the biomechanics of bipedal stance and stepping, and applies them to optimize control systems for maintaining erect balance or facilitating efficient walking. 2. Seated Balance and Wheelchair Propulsion: This research explores methods to control the paralyzed pelvis and spine to restore vertebral alignment, extend bimanual reach, provide active sitting balance, and enhance mechanical efficiency of manual wheelchair propulsion. Dr. Triolo documents the effects of modulating stiffness of the trunk on regulating upright posture to prevent falls from the wheelchair and expand control over objects in the environment. 3. Selective Peripheral Nerve Interfaces: Dr. Triolo has designed and verified the safety and performance of new, highly selective multicontact peripheral nerve electrodes capable of isolating functionally distinct fascicular groups within a common nerve trunk. Selectivly activating of independent groups of neurons can elicit multiple joint motions, or discrete sensations perceived as arising from the missing limb, from a common surgical site on the proximal nerve, and alternating between synergistic motor unit pools can prolong force output and delay onset of fatigue. 4. Natural Sensation for Lower Limb Amputees: This program applies selective multicontact nerve electrodes to activate the sensory components of the sciatic nerve above the knee in the residual limbs of amputees to induce sensations referred to the missing limb. Elicited sensory information is processed by the CNS in a manner similar to input from intact mechanoreceptors, and can improve standing and ambulatory ability after traumatic or diabetic limb loss, and is being integrating with motorized lower limb prostheses. 5. Neuromechanical Gait Assist Systems: Dr. Triolo develops novel exoskeletal systems to facilitate bipedal mobility for individuals with SCI or other neuromuscular disorders. His innovative “muscle first” approach integrates mechanical components with volitional or electrically activated muscle contractions to maximize physical benefit and achieve the walking speeds required for community ambulation.

Ronald J. Triolo 博士是康复研发服务部的高级研究职业科学家，也是终身教授凯斯西储大学生物医学工程教授，现任执行董事。 VA RR&D 先进平台技术中心负责开发新型医疗设备和 Triolo 博士为感觉运动障碍或肢体丧失的患者提供了辅助恢复技术。撰写了 150 多篇经过同行评审的出版物和教科书章节，并指导了 40 多名他目前领导独立研究项目。 Triolo 博士作为首席或联合首席研究员资助了 VA、NIH、DoD 和其他机构。进入美国医学与生物工程研究所，获得Paul B. Magnuson奖荣获 VA 颁发的康复研究与开发杰出成就奖被评为 2020 年杰出退伍军人健康管理局员工（荣誉奖） Triolo 博士为美国残疾退伍军人 (DAV) 设计、申请了专利并对其进行了评估。促进从坐到站的过渡并通过楼梯、坡道或其他建筑障碍，并且位于准备脊髓损伤（SCI）后运动的新干预措施的过程，以便在范围内传播 VHA。他的研究计划包括五个主要领域： 1. 用于站立和行走的植入式神经假体：Triolo 博士领导的跨学科团队致力于开发、部署和评估手术植入运动系统的临床结果他量化了 SCI 后下肢功能的神经假体的急性和慢性表现，并探索整合刺激和意志肌肉活动的新方法，他的团队创造了新的方法。计算工具来分析双足站立和迈步的生物力学，并应用它们来优化用于保持直立平衡或促进有效行走的控制系统。 2. 坐姿平衡和轮椅推进：本研究探索控制瘫痪者的方法骨盆和脊柱，以恢复脊椎排列，扩展双手的伸展范围，提供主动的坐姿平衡，以及 Triolo 博士记录了提高手动轮椅推进的机械效率的效果。调节躯干的刚度以调节直立姿势，以防止从轮椅上跌倒并伸展对环境中物体的控制。 3.选择性周围神经接口：Triolo博士设计并验证了安全性和性能新型、高选择性多接触周围神经电极，能够隔离功能不同的共同神经干内的束状群可以选择性地激活独立的神经元群。引起多个关节运动，或被认为是由缺失肢体引起的离散感觉，来自共同的近端神经的手术部位，协同运动单位池之间的交替可以延长力量输出并延迟疲劳的发生。 4. 下肢截肢者的自然感觉：该方案采用选择性多接触神经电极激活残肢膝盖上方坐骨神经的感觉成分截肢者感应缺失肢体的感觉信息由大脑处理。中枢神经系统以类似于完整机械感受器的输入方式，可以改善站立和行走能力创伤或糖尿病肢体丧失后的能力，并且正在与机动下肢假肢集成。 5. 神经机械步态辅助系统：Triolo 博士开发了新型外骨骼系统以促进为 SCI 或其他神经肌肉疾病患者提供双足移动能力，他的创新“肌肉优先”。该方法将机械部件与意志或电激活的肌肉收缩相结合最大限度地提高身体效益并达到社区行走所需的步行速度。