Do terpenes play a role in the stress-reducing effects of a forest bathing intervention?

萜烯在森林沐浴干预措施的减压作用中发挥作用吗？

基本信息

批准号：
10302512
负责人：
Gregory Bratman
金额：
$ 22.41万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10302512
关键词：
Address Adult Affect Affective Air Air Purifying Respirators Anxiety Area Auditory Bathing Blood Blood Pressure Breathing C-reactive protein Cities Clinical Complementary therapies Cross-Over Trials Crossover Design Development Dose Dropout Effectiveness Environment Environmental Wind Equipment Exposure to Foundations Future Goals Health Health Benefit Heart Rate Individual Inflammatory Inhalation Intervention Investigation Japan Laboratory Study Life Light Limbic System Link Measures Mental Depression Mental Health Mental disorders Methods Modernization Moods Nature Odors Olfactory Pathways Outcome Participant Pathway interactions Patient Self-Report Personal Satisfaction Pharmaceutical Preparations Physiological Physiology Play Population Process Psychiatric therapeutic procedure Psychophysiology Randomized Randomized Controlled Trials Reporting Research Risk Reduction Role Sample Size Science Serum Smell Perception Stress Temperature Terpenes Therapeutic Translating Trees Universities Urbanization Visual Washington Well in self Work anxiety treatment blood pressure reduction cost cytokine experimental study forest health inequalities heart rate variability improved limonene method development multisensory neurobiological mechanism novel novel strategies olfactory stimulus overtreatment particle primary outcome resilience secondary outcome stress reduction stress related disorder systematic review therapeutically effective tool treatment duration treatment effect volatile organic compound volunteer

项目摘要

Project Summary Anxiety, stress, and low levels of psychological well-being -- all byproducts of some aspects of modern living -- contribute substantially to the burden of poor health around the globe. One potentially low-cost, easy to administer, and non-addictive treatment option to address these outcomes may be provided by the benefits of a specific form of nature contact: "forest bathing". This therapeutic approach involves sitting in forested areas, and in some cases interacting with trees in guided ways. The specific ways in which individual components of multisensory inputs act together to instantiate the psychophysiological benefits of forest bathing are not well understood. The objective of this proposal is to investigate the contribution of the olfactory pathway to these benefits -- specifically the component of inhalation of volatile organic compounds (VOCs), including terpenes -- present in forest air. We will use an individual-level crossover design in which each session is conducted independently and on different days. Participants will be outfitted with a powered air purifying respirator (PAPR) to selectively modulate exposure to a natural suite of forest-derived volatile organic compounds (VOCs) while present in forest environments. Each participant will undergo two forest bathing sessions, one in which VOCs are not filtered (treatment condition), and one in which they are filtered (control condition). Sessions will be separated by a 5-day washout period for each participant, and order will be counterbalanced. We will estimate the average effect of treatment over 40 distinct treatment days against 40 distinct control/filtered days. Our power and sample size calculations (N = 40) were determined using previous nature exposure studies of similar cross-over design. We are adequately powered assuming the conventional targets of α = 0.05 and β = 0.80 with a 10% anticipated dropout rate, and including temperature, wind, and light variability during treatment days. The specific aim of this project is to 1) assess whether VOC inhalation regulates increases in the HF (ms[2]) component of HRV as the primary outcome (with decreases in blood pressure, heart rate, self-reported stress, and levels of inflammatory cytokines in serum included as secondary outcomes); and 1a) assess the degree of association of absorbed dose of seven forest-derived VOCs in serum (i.e., α-pinene, β-pinene, β-myrcene, ? 3- carene, d-limonene, β- carophyllene, α-humulene) with these outcomes. Our proposed research will further scientific understanding of the role that olfactory stimuli play in the multisensory processes that are responsible for the benefits of forest bathing. This work addresses several aspects of NCCIH Research Agenda with its specific focus on the development of methods that are key to the advancement of fundamental science as it relates to mental health and well-being. Our investigations will also contribute key evidence to the development of cross-cutting and novel complementary and integrative approaches to health and well-being outcomes. Our results can be used to inform and optimize future interventions that utilize forest bathing to reduce anxiety and stress, potentially contributing to its development as a complementary treatment option for these factors that decrease global well-being.

项目概要焦虑、压力和低水平的心理健康——现代生活某些方面的所有副产品——在很大程度上造成了全球健康状况不佳的负担，这是一种潜在的低成本、易于管理且不会成瘾的因素。解决这些结果的治疗方案可以通过特定形式的自然接触的好处来提供：“森林沐浴”这种治疗方法包括坐在森林地区，在某些情况下以引导方式与树木互动。多感官输入的各个组成部分共同作用以体现森林浴的心理生理益处的具体方式尚不清楚，该提案的目的是研究嗅觉通路对这些益处的贡献——特别是吸入的成分。森林空气中存在挥发性有机化合物 (VOC)，包括萜烯。我们将采用个人层面的交叉设计，其中每个课程都是在不同的日子独立进行的，参与者将配备电动空气净化呼吸器（PAPR），以选择性地调节对一系列源自森林的天然挥发性有机化合物的暴露。每位参与者将接受两次森林沐浴，其中一次未过滤 VOC（处理条件），另一次则经过过滤（对照条件），两次森林沐浴将相隔 5 天。每个参与者的清洗期，并且顺序将被平衡，我们将根据 40 个不同的控制/过滤天来估计治疗的平均效果，我们的功效和样本量计算 (N = 40) 是根据之前的自然暴露确定的。类似交叉设计的研究假设 α = 0.05 和 β = 0.80 的传统目标以及 10% 的预期退出率，并包括治疗期间的温度、风和光变化，我们的动力充足。天。该项目的具体目标是 1) 评估 VOC 吸入是否调节 HRV 的 HF (ms[2]) 部分的增加作为主要结果（伴随血压、心率、自我报告的压力和水平的降低）血清中的炎症细胞因子作为次要结果）；以及 1a) 评估血清中七种森林来源的 VOC（即 α-蒎烯、β-蒎烯、β-月桂烯、 ?3-蒈烯、d-柠檬烯、β-叶绿素、α-葎草烯）具有这些结果。我们提出的研究将进一步科学地理解嗅觉刺激在影响森林沐浴益处的多感官过程中所起的作用。这项工作涉及 NCCIH 研究议程的几个方面，特别关注开发对森林浴至关重要的方法。与心理健康和福祉研究相关的基础科学的进步，我们还将为健康和福祉结果的跨领域和新颖的补充和综合方法的发展提供关键证据。告知并优化未来的干预措施，利用森林沐浴来减少焦虑和压力，可能有助于将其发展为这些降低全球福祉的因素的补充治疗选择。